
Physionic
I simplify scientific studies for you. If you want a transparent, detailed source of information for your nutrition, health, performance, etc., welcome to Physionic!
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Latest episodes

May 28, 2022 • 1h 25min
Issues with Nutrition Documentaries; Caffeine and Performance - They Don't Always Mix.
Hi folks, in this episode I unintentionally discussed two topics. One, I planned on discussing, which was caffeine and it's performance effects in weight lifting and endurance. However, because I woke myself up to a nutrition documentary that I watched for 20 minutes or so before recording, I felt I had to get some things off my chest related to the second topic - nutrition documentaries. So, you have the distinct pleasure (or dismay) of listening to me ramble on both, but I hope that either way you learn something of use, especially related to caffeine.
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Video and Studies on Caffeine: https://youtu.be/9WTbwlU5yOs

Apr 14, 2022 • 1h 27min
Nutrition & Pharmaceutical Therapies: Fat related Cancers
In this episode, the first of a more relaxed, long form podcast style, we're going to dive into how fat relates to cancers - the mechanisms, but beyond that, the different therapies employed by pharmaceuticals, along with the use of nutrition to combat certain cancers.
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Related Videos:
Mechanisms: https://youtu.be/Ijt1lqxn2AQ
Therapies: https://youtu.be/iLdcoIIiByo
Scientific Review:
Reprogramming of Fatty Acid Metabolism in Cancer
British Journal of Cancer

Mar 31, 2022 • 14min
Let's Change how We do Things Here.
I think you'd be better served if we change how we do things on the Physionic Podcast.
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Mar 25, 2022 • 19min
Carbohydrates slow Metabolism and Mitochondrial Breathing.
In this episode, I'm going to begin the explanation as to what effects carbohydrates have on our metabolism, and one potential effect in our mitochondria.
Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs34%5D-a-high-carbohydrate-diet-lowers-the-rate-of-adipose-tissue-mitochondrial-respiration
Video: https://www.youtube.com/watch?v=7uBHNUSI6hI
Previous Video on Carbs and Metabolism: https://www.youtube.com/watch?v=xn8VJzGCK5U&t=2s
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Study:
A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration
Benjamin Bikman

Mar 18, 2022 • 29min
An Exception to the Insulin Sensitivity Effects of Saturated Fat [Study 31]
In this episode, we'll discuss a potential exception to the negative results on insulin sensitivity we've been discussing with the exposure to saturated fat.
Study, Notes, & Amendments: https://www.physionic.org/examine/%5B31%5D-palmitate-acutely-induces-insulin-resistance-in-isolated-muscle-from-obese-but-not-lean-humans
Video: https://youtu.be/ldUBG4-EJDo
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Study:
Palmitate acutely induces insulin resistance in isolated muscle from obese but not lean humans.
A Brianne Thrush

Mar 10, 2022 • 30min
Mitochondria & Diabetes: How Nutrition Connects the Two. [Study 32]
Hi all, in this episode, I'm going to describe to you how your nutrition, generally, affects your mitochondria in diabetes specific cells and how long term habits in nutrition can lead to diabetes (type 2). Enjoy.
Video Version: https://youtu.be/x6EOhTzVKsE
Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs32%5D-mitochondrial-dynamics-in-the-regulation-of-nutrient-utilization-and-energy-expenditure
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Study:
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure
Marc Liesa

Mar 3, 2022 • 35min
Your Nutrition affects your Mitochondria (Fasting vs Overconsumption) [Study 32]
In this episode, we'll be diving into two ways your mitochondria change their "behavior" to the exposure to different nutrition situations (high vs low nutrient presence).
Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs32%5D-mitochondrial-dynamics-in-the-regulation-of-nutrient-utilization-and-energy-expenditure
Video: https://www.youtube.com/watch?v=KQBmtzT4VTU
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Study:
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure
Marc Liesa

Feb 18, 2022 • 43min
Saturated vs Unsaturated Fats: One is Worse for Insulin Resistance [Study 30]
In this episode, we'll be going over a new study that wanted to find out the effects a saturated fat heavy consumption would have on insulin resistance and signaling against an unsaturated fat heavy consumption.
Video: https://youtu.be/QfII7CANt14
Study: https://www.physionic.org/examine/%5Bs30%5D-dietary-palmitate-and-oleate-differently-modulate-insulin-sensitivity-in-human-skeletal-muscle
MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING
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Sarabhai, T., Koliaki, C., Mastrototaro, L., Kahl, S., Pesta, D., Apostolopoulou, M., Wolkersdorfer, M., Bönner, A. C., Bobrov, P., Markgraf, D. F., Herder, C., & Roden, M. (2022). Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle. Diabetologia, 65(2), 301–314. https://doi.org/10.1007/s00125-021-05596-z

Feb 10, 2022 • 45min
Unsaturated Fat to the Rescue: Insulin Signaling and Mitochondrial Health [Study 28]
In this episode, we continue our quest for understanding the effect saturated fats have on muscle insulin signaling and mitochondrial health - however, beyond that, we'll be looking at how unsaturated fats may protect against the deleterious effects of saturated fat? Let's see..
Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs28%5D-different-effects-of-oleate-vs.-palmitate-on-mitochondrial-function%2C-apoptosis%2C-and-insulin-signaling-in-l6-skeletal-muscle-cells%3A-role-of-oxidative-stress-
Video: https://youtu.be/TiO16KoH0Fs
Study Title: Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress. Larysa Yuzefovych

Feb 4, 2022 • 24min
Saturated Fat - Friend or Foe for Insulin Sensitivity and Mitochondrial Function? [Study 27]
In this episode, I'm kicking off a new format that's more tailored to the podcast listeners, so there's less need to head to the video versions of the podcast to understand half of what I'm talking about. In this episode, we'll be discussing saturated fat (palmitate) and it's effects in relation to insulin signaling in muscle cells, as well as mitochondrial function. What are the effects? What are the implications?
Video: https://youtu.be/zMkV91E2Bic
Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249685/
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