Blood Podcast

Delve into the fascinating world of genetics as the discussion unfolds on heredity versus environment in age-related clonal hematopoiesis. Discover groundbreaking insights into mutations of the thrombopoietin receptor and their implications for myeloproliferative neoplasms. The role of complement activation is also highlighted, especially relating to thrombotic disorders. This engaging exploration sheds light on the urgent need for enhanced diagnostics and therapeutic strategies in hematologic conditions.

Exploring breakthroughs in treating T-cell acute lymphoblastic leukemia, the discussion highlights intensified pediatric protocols and innovative therapies, including case studies showcasing successful outcomes. It also delves into the use of a thrombopoietin agonist to address thrombocytopenia after stem cell transplants. Furthermore, the talk reveals exciting advances in microRNA-146a for targeted treatments, emphasizing its potential antitumor effects, especially in patients receiving CAR T-cell therapy.

This episode will explore the consequences of a loss of the interaction between mutant calreticulin and another ER resident protein, and how this may promote myeloproliferative neoplasms, the role of a calcium-induced transcription factor in driving diffuse large B-cell lymphoma signaling, and a comparison of two therapies for standard risk acute graft-versus-host disease.

This episode will highlight a unique treatment for refractory hematologic malignancies, therapy-induced mutations impacting the genomic landscape of relapsed acute lymphoblastic leukemia, and a unique approach to avoiding chronic graft-versus-host disease.

This episode highlights articles and commentaries that help expand our understanding of prognostic biomarkers in CLL, learn more about a streamlined analysis of the granulocyte transcriptome in myeloproliferative neoplasms, explore the role of neutrophil extra cellulartraps in adenosine deaminase deficiency, and examine the function of the plant homeodomain-like finger protein 6, in hematopoietic stem cell self-renewal.

The topics in this episode include studies on the mechanism of progression in myelodysplastic syndromes, the value of gait speed as a predictor of outcomes in older adults with hematologic malignancies, the role of extended eltrombobag therapy on severe aplastic anemia, and the role of the Hedghog pathway mutations in chronic lymphocytic leukemia.

Delve into the complexities of hemophagocytic lymphohistiocytosis and the promising role of ruxolitinib in treatment. Discover the efficacy of CAR T-cell therapy for treating B-cell lymphomas, especially follicular lymphoma. Learn about the intriguing links between blood cell interactions, sickle cell trait, and thrombosis. Finally, explore how mutated calreticulin influences myeloproliferative disorders and the emerging strategies for addressing these health challenges.

Explore the cutting-edge advancements in treating classical Hodgkin's lymphoma, highlighting the powerful role of checkpoint inhibitors and their impact on patient outcomes. Delve into the immune mechanisms of transfusion-related acute lung injury, focusing on osteopontin and its influence on neutrophil activity. The discussion also covers B-1 progenitor acute lymphoblastic leukemia and introduces innovative treatment strategies for heparin-induced thrombocytopenia, showcasing promising developments in hematological conditions.

The article highlighted in this trailer "The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells"  was published June 6, 2019; Blood, Volume 133, Issue 23. The authors of this article are: Satoru Miyagi , Patrycja Sroczynska , Yuko Kato , Yaeko Nakajima-Takagi , Motohiko Oshima , Ola Rizq , Naoya Takayama , Atsunori Saraya , Seiya Mizuno , Fumihiro Sugiyama , Satoru Takahashi , Yumi Matsuzaki , Jesper Christensen , Kristian Helin , Atsushi Iwama.