Blood Podcast

In this week’s episode, we will learn more about the role of hepcidin in fetal iron homeostasis, review a new study with improved outcomes in HLA-antigen mismatched transplantation, and examine how two splicing factor mutations can coexist in the same cell in patients with myeloid malignancies.

In this week’s episode, we will examine the effects of protecting and regenerating Paneth cells and intestinal stem cells in acute-graft-versus-host-disease, learn more about how Plasmodium falciparum gametocytes develop in the bone marrow by invading erythroblasts, and look at a meta-analysis of direct oral anticoagulants for treating cancer patients with acute venous thromboembolism.

Rachel Grace, a pediatric hematologist at the Dana-Farber Boston Children’s Cancer and Blood Disorder Center, discusses advancements in understanding and treating pyruvate kinase deficiency. Achille Iolascon, a professor of medical genetics, shares insights on congenital dyserythropoietic anemias. They delve into breakthroughs in pharmacological treatments, including gene therapy, and the complexities of diagnosing inherited anemias. The conversation highlights the importance of genetic research and its potential to improve patient care and treatment outcomes.

In this week’s episode, we start by reviewing two studies on the risks of transmitting HIV from transfusion. The first study asks whether changing the US blood donation policy for men who have sex with men from an indefinite deferral, to a deferral of 12 months from last sex, increases the risk of transfusion-transmitted HIV. The second study examines the frequency of detecting anti-HIV retroviral drugs in the serum of people attempting to donate blood. We will also review a manuscript examining the impact of Myc in HIV-associated non-Hodgkin lymphomas treated with EPOCH chemotherapy with or without vorinostat. And lastly, we learn more about platelet hyperactivity in two recent studies of patients with COVID-19.

In this week’s episode, we will learn about vasomotor hyper-responsiveness in sickle cell disease, examine the role of neutrophil extracellular traps in the pathophysiology of immunothrombosis in COVID-19-associated acute respiratory distress syndrome, and discuss a large series evaluating allogeneic hemopoietic cell transplantation in chronic granulomatous disease.

In this week’s episode, we will review a study that identifies a new modular organization of erythropoiesis and offers a novel strategy to overcome chronic anemias, summarize a study that used data from two large phase three trials to examine the risk of thrombosis in patients with newly diagnosed multiple myeloma, and review the first report of autosomal recessive germline TET2 deficiency, which results in immunodeficiency, autoimmune lymphoproliferation, and lymphoma.

In this week’s episode we will review a study exploring recurrent somatic deletions at chromosome 13q12.2 in acute lymphoblastic leukemia leading to upregulation of FLT3, examine how matriptase-2 plays a key role in suppressing hepatic hepcidin expression, and learn about the addition of daratumumab to lenalidomide, bortezomib, and dexamethasone as a quadruple therapy for transplant eligible patients with newly diagnosed multiple myeloma.

In this week’s episode we will review a study exploring the use of demethylating agents in patients with adult T-cell leukemia-lymphoma, learn more about hematopoietic stem cell formation, and examine treatment timing and prognosis in newly diagnosed patients with acute myeloid leukemia.

In this week’s episode we will review a study exploring the use of a novel hemophilia A mouse model to examine emicizumab function in vivo, a new approach to fighting the cytokine storm of HLH with a combination of glucocorticoids and ruxolitinib, and a timely Letter to Blood about red cell-bound antibodies and transfusion requirements in hospitalized patients with COVID-19.

In this week's episode we will review a study that demonstrates how the impaired hematopoietic stem cells (HSCs) observed in β-thalassemia can be rescued by administration of parathyroid hormone, learn more about genetic variants that can increase the risk of venous thromboembolism, and explore the identification of two DNA methylation subtypes of Waldenström’s macroglobulinemia.