The Chain: Protein Engineering Podcast

The coronavirus has swept the globe, bringing governments, economies, and society to its knees. Infectious disease expert, Dr. Rita Rio discusses current suppression policies and long-term implications for the public, as well as healthcare systems and the scientific community. 

Today’s episode features a conversation with Dr. Tatiana Novobrantseva, Co-Founder and CSO of Verseau Therapeutics.  In this interview, we discuss five trends in the development of cancer immunotherapies and how these will impact patients and biopharmaceutical research and development.

Science Commune is a segment of The Chain that goes beyond the science and explores the people making discoveries. We discuss their career paths, passions, and the people who inspired them along the way. Join Dr. Daniel Chen as he speaks with Dr. Bruce Keyt, who is the Chief Scientific Officer at IGM Biosciences about connections between engineers, biologists, artists, and the inspiration that sparks innovation. 

Hank Greely, JD is a leading expert in law, and particularly its applications in scientific advancement, and the ethical concerns brought about by gene editing, specifically. Recent events, including the He Jiankui case, have captured international attention as the scientific community, national governments, and citizens of the world ask, “How far is too far?” when it comes to gene editing. Dr. Greely lends his insight into the case and shares the biggest lessons we can learn and apply to future advancements. 

Today’s episode continues the conversation with the 2019 and 2020 PEGS Young Scientist Keynote speakers, focusing on the challenges of their day to day work, the translation of major biotherapeutic and vaccine projects into the clinic and tips for young scientists considering careers in the field. 

Today’s episode features a conversation with the 2019 and 2020 PEGS Young Scientist Keynote presenters. We explore their work in protein science, its impact on global health and some exciting initiatives now underway in their labs. 

Some scientists dream of genes. Cenk Ündey dreams of intelligent data flow through the value-added chain of biotherapeutic protein development. Ündey is an Executive Director of Process Development at Amgen. He sits down with The Chain to describe a system of streamlined and effective data management at every step: From molecule delivery to working with suppliers. Thanks to advanced computing power, broader datasets, and improved storage, this dream is closer to realization than ever before. 

One of the greatest afflictions associated with cancer is its spread throughout the body and organs, known as metastasis. What if a therapeutic could be engineered to block the pathway of metastasis, thus blocking cancer’s progress? This is precisely the crux of Dr. Jamie Spangler’s research. Her group has, first, delineated cancer’s pathway, and, secondly, has engineered multi-specific antibodies that potently block metastasis. Dr. Spangler’s work combined with anti-cancer therapies shows exciting promise in the fight to overcome the ravages of cancer. In this podcast, Dr. Spangler discusses her work in considerable detail, and also describes her personal journey and transformation into protein science. 

Javin Oza observed the separation of scientists and engineers on university campuses, at conferences, and in classrooms. Yet he also noted that advances in biochemistry require perspectives from both bioengineers and lab scientists. Oza’s current research aims to bridge the gap between these thought-approaches to bring about advancements in cell-free protein synthesis. He speaks with The Chain about barriers to implementing CFPS, what resources are available for the transition to cell-free systems, and advice for young protein scientists. 

Dr. Paolo Arosio Professor of Biochemical Engineering at ETH Zurich speaks to Nandini Kashyap, Conference Director at CHI about his love for building blocks and how he is applying microfluidics to solve challenges in biologics product development. They discuss the role of protein aggregation and developability in taking the molecules from a sequence to a drug product.