PICU Doc On Call

The podcast discusses the case of a 2-year-old girl with acute respiratory distress and the use of High-Flow Nasal Cannula (HFNC) therapy. They explore the mechanisms and advantages of HFNC, including improved oxygen efficiency and reduced upper airway resistance. The podcast also debunks the myth of PEEP theory in HFNC and emphasizes the importance of monitoring parameters for assessing its efficacy. Finally, they summarize the physiologic effects of HFNC and encourage listener feedback.

An 8-year-old boy with chest pain, fatigue, and decreased oral intake is admitted to the PICU. They discuss the pathophysiology and epidemiology of acute rheumatic fever, its manifestations and diagnostic measures. Management goals include eliminating strep infection, controlling inflammation, and preventing recurrence. They also explore the use of biomarkers for early detection and treatment of acute rheumatic fever.

The podcast delves into pediatric drowning cases in the PICU, covering topics like severe respiratory failure, electrolyte imbalances, and neurological complications. It clarifies drowning terminology, discusses pathophysiology including laryngospasm and gas exchange compromise. The episode emphasizes treatment approaches, prognostic factors, and the importance of immediate resuscitation and inpatient therapeutic strategies.

Pediatric ICU physicians discuss lactic acidosis in a 4-year-old boy with hypotension, fatigue, and respiratory distress. They explore the causes, types, and management of lactic acidosis in the PICU. The use of blood lactate levels as markers, the phenomenon of lactic acid washout, and the controversy surrounding bicarbonate therapy are also discussed.

In this episode of PICU Doc On Call, Dr. Pradip Kamat and Dr. Rahul Damania discuss a case of a 4-year-old girl with bite marks and swelling of her foot, presenting with concerning vital signs and abnormal labs. They explore snake envenomation and its management in the pediatric critical care setting.Classifying Snake EnvenomationSnakes with venom-delivering fangs, primarily Elapidae and Viperidae, are responsible for most human envenomations and fatalities. We're focusing on Pit Vipers today, including rattlesnakes, cottonmouths, and the copperhead. Elapids, such as the coral snake, differ by having round pupils, short fangs, and no facial pit.Risk Factors for Pediatric SnakebitesSnakebite incidents can happen when toddlers unintentionally disturb snakes, particularly in low-light conditions or grassy areas. Teenagers trying to capture snakes are another frequent group presenting with upper extremity bites. Pathophysiology of Snake EnvenomationSnake venoms contain toxic proteins that affect various physiological systems, leading to neurotoxic, hemotoxic, myotoxic, or cytotoxic effects. Envenomation can happen immediately or be delayed, presenting with various clinical and laboratory anomalies.Syndromes Observed After Snake EnvenomationThe impact of a snakebite depends on the snake type, fang size, and venom injection site. Effects may include cytotoxicity, lymphatic system damage, platelet dysfunction, neurotoxicity, cardiotoxicity, hypotension, and nephrotoxicity.General Management FrameworkIn snakebite cases, prehospital care involves immediate EMS call and ensuring airway, breathing, and hemodynamic stability. In the hospital, general supportive care is crucial, and antivenin administration depends on clinical presentation and snake type.Antivenin ConsiderationsAntivenin dosage is challenging due to unknown venom load, and its choice depends on safety, kinetics, cost, and the specific snake involved. Smaller fragments of antivenin have larger distribution volumes and shorter half-lives. Recurrence, anaphylaxis, and serum sickness are potential side effects of antivenin.Clinical PearlsA high index of suspicion is required to diagnose snake envenomation.Antivenin is the mainstay of therapy, and rapid transport to a facility with antivenin is crucial.Patients should be educated about recurrence, serum sickness, and lifestyle adjustments after a pit viper bite.Thank you for listening to this episode on snake envenomation in the PICU. For more episodes, visit our website picudoconcall.org. Stay tuned for our next episode! Don't forget to share your feedback and subscribe to our podcast.

In this episode PICUDoc On Call, we discuss the case of a six-month-old ex-preemie with bacterial meningitis who presents with symptoms of cerebral sinus venous thrombosis. We explore the anatomy of the venous distribution in the brain and the clinical syndromes associated with sinus venous thrombosis. Our focus is on the imaging techniques, laboratory tests, and management strategies involved in diagnosing and treating this challenging condition.You will learn:A six-month-old ex-preemie presents with persistent fever, recurrent emesis, and increased somnolence.The patient experiences eye rolling and decreased oxygen saturation, prompting a visit to the emergency department.Physical examination reveals rigidity in all four limbs, and a head CT shows dilated ventricles and encephalomalacia.Lumbar puncture confirms an infection, and the patient is admitted to the hospital.After a 14-day course of antibiotics, the patient's clinical status worsens, leading to intubation and neurosurgery consultation.An MRI confirms cerebral venous sinus thrombosis.Anatomy of Venous Distribution in the Brain:Dural venous sinuses serve as conduits for venous blood return from the brain to the internal jugular veins.The superior sagittal sinus, cortical veins, transverse sinus, sigmoid sinus, and internal jugular vein are key components of the venous drainage system.Clinical Syndromes of Sinus Venous Thrombosis:Symptoms can be related to elevated intracranial pressure or focal brain damage from venous ischemia, infarction, or hemorrhage.Headache, seizures, focal neurologic deficits, and cranial nerve paralysis are common presentations.Cavernous sinus thrombosis can cause periorbital pain, ocular chemos, and paralysis of cranial nerves passing through the sinus.Risk Factors for Cerebral Sinus Venous Thrombosis:Dehydration, CNS or sinus infections, intracranial surgery, autoimmune disorders, genetic syndromes, metabolic syndromes, medications, and genetic thrombophilic states can predispose children to thrombosis.Thorough evaluation for risk factors, including thrombophilia, is recommended in children with cerebral venous thrombosis.Imaging and Laboratory Tests:CT and MRI with contrast-enhanced venography are preferred imaging tools to detect cerebral sinus venous thrombosis.Non-enhanced CT scans and T1/T2-weighted MRI scans show characteristic signs of thrombosis.Lab tests include CBC with differential, DIC panel, comprehensive metabolic panel, ESR, and specific thrombophilia tests.Management Strategies:Supportive care, including airway management, hemodynamics, and neurologic monitoring, is crucial.Consultation with a multidisciplinary team (neurosurgeons, neuro-interventional radiologists, hematologists, etc.) is necessary.Anticoagulation therapy with heparin is initiated and closely monitored.Surgical interventions (e.g., EVD placement, ventricular peritoneal shunt, decompressive hemicraniectomy) may be required in severe cases.Long-term rehabilitation may be necessary for neurological deficits.In summary:Cerebral sinus venous thrombosis in pediatric patients requires a multidisciplinary approach for prompt diagnosis and management. Recognizing the clinical signs, conducting appropriate imaging and laboratory tests, and initiating timely interventions are crucial for improved outcomes.

Pediatric ICU physicians discuss a case of a 5-year-old with unexplained fatigue and fever, exploring genetic blood disorders, physiological adaptations in severe acute anemia, different types of hemolytic anemias, and management of hereditary spherocytosis in the PICU.

Welcome to "PICU Doc On Call," a podcast dedicated to current and aspiring intensivists. In this episode, Dr. Pradip Kamat and Dr. Rahul Damania discuss an interesting case of a 16-year-old male with high-grade fever and abdominal pain. The patient also presents with a rash and other concerning symptoms, leading to urgent medical attention. They provide a summary of the key elements from the case, including vital signs, physical examination findings, and laboratory and imaging results.Dr. Kamat then shares his thought process regarding the working diagnosis for this patient, considering several possibilities such as severe bacterial infection, atypical appendicitis or cholecystitis, toxic shock syndrome, and systemic inflammatory processes like Multisystem Inflammatory Syndrome in Children (MIS-C) and atypical Kawasaki disease.Moving on to the topic of vasopressors, Dr. Damania explains the importance of understanding how these medications work and their specific pharmacological properties. They discuss the classification of shock as cold or warm and the limitations of relying solely on clinical signs to categorize septic shock in children.They highlight the challenges in selecting the appropriate vasopressor, such as a lack of standardization in clinical examination and individual variability in response to medications. They emphasize the need for a comprehensive approach when evaluating and managing pediatric shock patients, considering multiple factors beyond traditional bedside signs.The hosts then engage in a rapid review of pressors, starting with a multiple-choice question regarding the choice of vasoactive infusion for a patient with toxic shock syndrome. They discuss the pros and cons of using norepinephrine (NE) in distributive shock and highlight its vasoconstrictive effects, inotropic activity, and potential side effects.They proceed to compare NE with epinephrine, explaining the differences in their actions on adrenergic receptors and their effects on various circulations. They mention that epinephrine acts on all adrenergic receptors and has hemodynamic and metabolic effects, redirecting cardiac output and increasing myocardial oxygen demand.Lastly, the hosts touch on phenylephrine, a vasopressor that acts on the alpha-1 receptor and elevates systemic vascular resistance (SVR) and pulmonary vascular resistance (PVR). They stress the importance of securing central line access when administering vasopressors to avoid harm to peripheral and systemic tissues.In conclusion, this episode provides valuable insights into the diagnosis and management of a complex pediatric case involving high-grade fever, abdominal pain, and shock. The hosts also offer a rapid review of common vasopressors, highlighting their mechanisms of action, pros, and cons.

Today’s episode of "PICU Doc On Call," with Dr. Pradip Kamat and Dr. Rahul Damania, pediatric ICU physicians, delves into intriguing case and management strategies within the acute care pediatric setting.This episode focuses on a 2-year-old child transferred to the PICU due to pneumonia-induced respiratory distress. As the child's condition deteriorates, intubation becomes necessary to address acute hypoxemic respiratory failure.We discuss the significance of minimizing unnecessary blood cultures in febrile patients with central lines in the PICU. A study implementing a quality improvement program is referenced, which successfully reduces blood culture rates, broad-spectrum antibiotic usage, and CLABSI rates without impacting mortality or length of stay.Next, we’ll explore the comparison between a high-flow nasal cannula (HFNC) and continuous positive airway pressure (CPAP) in pediatric patients experiencing respiratory distress. Findings from a randomized controlled trial revealed that HFNC is non-inferior to CPAP in terms of time required for liberation from respiratory support.We further investigate the application of pediatric early warning scores (PEWS) and automated clinical prediction models to identify patients at risk of deterioration and transfer to the PICU. The importance of employing clinical judgment and a combination of assessment tools to determine the need for transfer is emphasized.Lastly, we’ll highlight the significance of screening for social determinants of health in critically ill children and their families. A study demonstrates that a substantial number of participants had unmet social needs, underscoring the importance of screening to provide appropriate interventions and resources.To summarize, this podcast episode covers key topics such as reducing unnecessary blood cultures, comparing HFNC and CPAP in respiratory distress, utilizing PEWS and clinical prediction models for patient identification, and the importance of screening for social determinants of health.Be sure to listen in entirety as we discuss the case.

Welcome to PICU Doc On Call, A Podcast Dedicated to Current and Aspiring Intensivists.I'm Pradip Kamat coming to you from Children’s Healthcare of Atlanta/Emory University School of Medicine. I'm Rahul Damania from Cleveland Clinic Children’s Hospital and we are two Pediatric ICU physicians passionate about all things MED-ED in the PICU. PICU Doc on Call focuses on interesting PICU cases & management in the acute care pediatric setting so let’s get into our episode.Today, we are going to discuss the management of the postoperative patient admitted to the PICU. Our discussion will focus on the non-cardiac and non-transplant admission. Our objective in this episode is to create a framework on what areas of care to focus on when you have a patient admitted to the PICU post-operatively. Each surgery and patient is unique; however, we hope that you will garner a few pearls in this discussion so you can be proactive.in your management. Without any further delay, let’s get started with today’s case:We begin with a 13-year-old child, Alexa, with h/o of a genetic syndrome, who presents today with a history of thoracolumbar kyphoscoliosis. Over the years, Alexa's curvature has progressively worsened, resulting in difficulty breathing and chronic back pain. The decision was made to proceed with a complex spinal surgery, including posterior spinal fusion and instrumentation.In the weeks leading up to the surgery, Alexa underwent a thorough preoperative evaluation, including consultations with specialists and relevant imaging studies. Pulmonary function tests revealed a restrictive lung pattern, while the echocardiogram showed no significant cardiac abnormalities. Preoperative labs, including CBC, electrolytes, and coagulation profile, were within normal limits.During the surgery, Alexa was closely monitored by the anesthesia team, who administered general anesthesia with endotracheal intubation. The surgery was performed by the pediatric neurosurgery and orthopedics, with intra-operative neuromonitoring to assess spinal cord function. The surgical team encountered an unexpected dural tear, which was repaired using sutures and a dural graft. Due to the prolonged surgical time, a temporary intra-operative loss of somatosensory evoked potentials was noted. However, signals were restored after adjusting the patient's position and optimizing blood pressure. The posterior spinal fusion and instrumentation were completed successfully, but the surgery lasted 8 hours. Total intra-operative blood loss was 800 mL, and Alex received 2 units of packed red blood cells and was on NE for a little over half the case before weaning off.Alexa was admitted to the PICU intubated and sedated for postoperative care. The initial assessment showed stable vital signs, with a systolic blood pressure of 100 mmHg, heart rate of 90 bpm, and oxygen saturation of 99% on mechanical ventilation. Postoperative pain was managed with a continuous morphine infusion. The surgical team placed a closed suction drain near the surgical site and a Foley catheter for urinary output monitoring. You are now at the bedside for OR to PICU handoff…To summarize key components from this case:This is a patient with thoracolumbar kyphoscoliosis, underwent complex spinal surgery (posterior spinal fusion and instrumentation) due to progressive curvature, breathing difficulties, and chronic pain.She had a course intra-operatively, where an unexpected dural tear occurred, requiring repair with sutures and a dural graft. Temporary loss of somatosensory evoked potentials was resolved through patient repositioning and blood pressure optimization with NE.She had a moderate amount of blood loss in the case and is back intubated, sedated, with surgical drains in place.So Pradip, we see patients such as Alex in our PICU commonly, if we take a step back what is your general approach with children who are admitted to the PICU post operatively?I think it's crucial to approach the care of postoperative children in the PICU systematically and proactively. This involves closely monitoring their changing physiology, anticipating potential complications, and collaborating with the surgical team to address any concerns. By maintaining open communication and following evidence-based guidelines, we can optimize patient outcomes and facilitate a smooth recovery process.💡Just as a quick tid-bit, while some of these PICU admissions are scheduled, there is literature to suggest that up to 24% of non-cardiac surgeries may result in unanticipated admissions to the PICU. An single center study published in 2017 in PCCM looked at their rates of unanticipated PICU admissions from the OR, and they found that these children spend twice as much time on mechanical ventilation and that airway abnormalities, anesthetic factors, and intra-operative hypoxia contribute to such admissions.Alright, Pradip, we are now at the post operative handoff and the first person who is going to be giving report is the anesthesia team. Can you please highlight what are some key things to listen out for during their sign out and what are some questions to ask?Great question! The anesthesiologist plays a crucial role in ensuring the patient's airway and hemodynamics are properly managed during surgery, which is essential for a safe and successful procedure. It's important for the anesthesiologist to communicate with the PICU team regarding: induction, intraoperative course, line & tubes, as well as pain management.Let’s break these down:So for induction, you want to know were the anesthetics administered through IV or general anesthesia, was it a smooth process or were there difficulties, and what was used for anesthesia maintenance.Next you want to know about the airway.You want to gather essential information about the patient's airway management. Find out if an LMA or ETT was used during the procedure. If the patient was intubated, inquire about the ease of bag-mask ventilation and laryngoscopy, as well as the grade of the glottic view (e.g., Grade 1) and the type of laryngoscope used, including if video laryngoscopy was employed. It's also important to know the number of intubation attempts. Additionally, gather details about the type of ETT (regular or neo-cuff), its size, and the length at which it is taped to the gum or teeth. Finally, ask if any airway adjuncts were utilized during bag-mask ventilation or intubation.🚨Remember that a key management point as soon as handout is completed is to obtain a CXR to confirm tube placement, and work closely with your RT to secure the tube in the correct position.That’s so true!As you wrap up anesthesia sign out, here are some other things to think about:Oxygenation/Ventilation: Determine if the patient was easily oxygenated and ventilated, or if any bronchospasm or laryngospasm occurred during the case.Lines & Tubes: Inquire about IV or central access, arterial line usage, and the presence of any drains or tubes (e.g., NG, Foley).I/Os: Understand the management of fluid, electrolyte, and glucose homeostasis during anesthetic care, including the types and rates of fluids administered, blood product usage, and estimated blood loss.Pain Management: Gather information on the analgesics, sedatives, and neuromuscular blockers used.Other Medications: Be aware of antibiotics, antiemetics, anticholinergics, and other medications administered during the procedure.Duration of the Case & Patient Position: Obtain information on the duration of the surgery and the patient's position (e.g., supine or prone, as in spinal cases).Latest Set of Vital Signs: Ensure you have the most recent vital signs recorded.⚖️A nice mnemonic that I use is:A - Airway: LMA/ETT, ease of ventilation, glottic view, laryngoscope typeP - Pain Management: Analgesics, sedatives, neuromuscular blockersI - I/Os: Fluids, blood products, estimated blood lossL - Lines & Tubes: IV/central access, arterial line, drains, NG, FoleyO - Oxygenation/Ventilation: Oxygenation ease, bronchospasm, laryngospasmT - Time & Position: Duration of case, patient position (supine or prone)Especially when it comes to access, coordinating with your PICC team, surgery colleagues, or anesthesia teams of long term access or additional PIVs which can be placed while the patient is under anesthesia is key!Absolutely, Rahul! It’s important for us to also recognize that general anesthesia can cause vasodilation, and when combined with surgical blood loss and insensible losses, it increases the need for fluids postoperatively. Factors like prone positioning and mechanical ventilation can also affect urine output, making it a less reliable indicator of intravascular volume. In the postoperative period, it's important to administer isotonic fluids to avoid hyponatremia and watch for SIADH. Additionally, since operating rooms can be cold, it's crucial to monitor the patient's temperature, especially in infants, to prevent complications like arrhythmias and coagulation disturbances due to hypothermia.Let’s transition, Pradip. When admitting a postoperative patient to the PICU, what essential questions should we ask the surgeons?As we have our patient post-op in the PICU, we need to have a clear understanding of the type of surgery performed. Additionally, we should ask these key questions to ensure comprehensive patient management. Communication is essential!We have arranged this into organ systems, and while not all of these questions would be applicable to every case, this list is relatively comprehensive!Let’s start with our first organ system:CNS:What are the acceptable pain management medications for the immediate post-op period? Can we consider PCA, non-opioids like ketorolac or other NSAIDs, or IV acetaminophen?Are there any activity restrictions for the patient, or can they be mobilized early? When can we involve PT/OT and speech therapy in the patient's care?Respiratory:2) If the patient is admitted to the PICU intubated, when can they be extubated?If extubation is unsuccessful, can non-invasive positive pressure ventilation, such as HFNC or BiPAP, be used? This is especially true for intra-abdominal procedures.Is perioperative dexamethasone appropriate?Are there any procedures like MRI or a revisit to the operating room needed prior to extubation?⚖️Just to loop back to a prior concept which we discussed, you want to know if the patient at minimum can be bag masked, was the airway difficult, if there is an acute airway event should the PICU team be the primary team to intubate or should this be an intubation by Anesthesia or ENT.Cardiovascular:3) What are the target blood pressure goals (systolic or MAP) for the patient postoperatively?This will be especially true for neurosurgical procedures and even transplant patients.⚖️If you have yet to check them out, please consider listening to our prior episodes on the post operative approach to Renal transplant and Liver tranplant in the PICU!Fluid, Electrolytes, and Nutrition/GI:4) When can the patient begin clear fluids and advance their diet?Renal:5) Can the Foley catheter be discontinued, and if so, when?Talk about urine output goals when applicable.⚖️Also note that another output which you may have to keep in mind will be how much drainage will be coming out of your peritoneal, penrose, CSF drain — clarifying thresholds of quality and quantity of drainage with your surgical teams can really help with effective recognition of post operative complications. Coordinating a plan to replace the excessive out fluid and with type of fluid is key?Hematology:6) Which labs (such as CBC, electrolytes, or coagulation profile) need to be obtained, and how frequently?Are there any specific transfusion goals?Infectious Diseases:7) What antibiotics are prescribed, and for what duration? If the patient becomes febrile, should cultures be obtained?⚖️Alright summary, analgesia, airway, BP goals, diet/activity, transfusion thresholds, antibiotics & repeat imaging.Rahul, there seem to be several logistical questions to consider as well. Could you please highlight the key aspects for us?Certainly, it's crucial to address logistical factors in postoperative care. Firstly, we need to determine when a patient, who is extubated and on room air and hemodynamically stable, can be transferred out, especially if bed capacity is limited. Secondly, it's essential to verify whether the child's family or guardians have been updated on their condition. Lastly, we should inquire about any additional consults that need to be placed for the PICU team to ensure comprehensive patient care.We want to conclude this episode by delving deep into a few of the patients which are commonly admitted to the PICU post operatively. Our goal here is to apply the principles of management we just learned.The first case we want to return to is our post-operative spinal fusion.How does their pre-op status influence the post-op course?The post-op course depends on pre-op status, pulmonary function, degree of curvature, and extent of repair. Key concerns include paralysis, pain management, airway maintenance, and pulmonary hygiene.⚖️The key here is to work closely with your pulmonary colleagues and RT to coordinate an effective bronchopulmonary hygiene regimen while admitted in the hospital as effective airway clearance can optimize cardiorespiratory status.What complications should we watch for due to spinal cord manipulation?Watch for SIADH and check sodium levels if urine output decreases. A high heart rate might be due to pain, so check intra-operative records for more information.Alright our next Rapid Fire Case: ENT or OMFS procedures like tracheostomy, TNA, SGP, and airway reconstruction!What should we know about post-op management for typical ENT procedures like tracheostomy or airway reconstruction?Get information on bag-mask ventilation and intubation options in case of unplanned extubation. Check if NIPPV is contraindicated. Be prepared for blood loss, post-op swelling, and airway emergencies with wire cutters and spare tracheostomy.How should we handle a dislodged tracheostomy in a fresh case?Consult the ENT surgeon for a fresh tracheostomy dislodgment. Forcing a trach can create a false track. Some trachs have stay sutures for guidance. Difficult airway patients may need deep sedation or paralysis until the first tracheostomy change.💡In airway emergencies it is vital to remember that what...