

Peptides and Longevity: Redefining Aging and Transforming Health with Dr. Kent Holtorf
Kent Holtorf, MD
Join Dr. Kent Holtorf as he explore groundbreaking science, innovative therapies, and the future of health and aging. In each episode, he dives deep into the world of peptides—potent molecules that regulate immune function, boost cellular regeneration and optimize metabolism. Through conversations with leading experts, Dr. Holtorf explains how peptides differ from traditional hormones, their role in reversing chronic illness, and their potential to enhance sleep, brain function, and overall vitality.
https://holtorfmed.com/
https://integrativepeptides.com/
https://holtorfmed.com/
https://integrativepeptides.com/
Episodes
Mentioned books

Dec 10, 2025 • 1h 2min
The Precision Medicine Approach to Neurodegenerative Diseases and Total Body Health
What if your concussion wasn’t just about the hit to your head, but everything that was already simmering in your body? In this episode of Peptides and Longevity, neurosurgeon and functional medicine practitioner Dr. Chad Prusmack joins us to unpack precision medicine, environmental subconcussion, and why toxins, infections, autonomic imbalance, and data-driven rehab can make or break brain recovery.----Dr. Chad Prusmack is a board-certified neurosurgeon and one of the only neurosurgeons in the United States to also hold a functional medicine certification. After years of operating in traditional neurosurgery, he saw too many patients whose scans looked ‘perfect’ but who were still suffering, which pushed him to integrate multi-omics, precision testing, and systems-level thinking into his practice.He is the founder of Resilience Code, a 45,000-square-foot health and performance center in Denver that blends neurosurgery, functional medicine, strength and conditioning, neurofeedback, and comprehensive rehab under one roof. As a primary neurosurgical consultant for the Denver Broncos and the United States Olympic Committee, he specializes in neurodegenerative disease, concussion, post-concussion syndrome, and performance medicine. His mission is to shine a high-definition light on the continuum between ‘healthy’ and ‘diseased,’ so patients can finally understand why they feel the way they do and what to do next.----Dr. Chad PrusmackWebsite: myresiliencecode.comWebsite: healthonephysiciangroup.com/physicians/profile/Dr-Chad-J-Prusmack-MDLinkedIn: linkedin.com/in/chad-prusmack-58552020----Visit www.integrativepeptides.com and use the code PODLIFE to get 10% off your first purchase.----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalkshttps://drtalks.com/podcast-service/

Dec 3, 2025 • 43min
Functional Genomics with Bob Miller
What if your iron wasn’t just high but actively damaging your cells? In this episode of Peptides and Longevity, Bob Miller joins us to explore a little-known process called ferroptosis: a kind of ‘iron overload gone wrong’ that may help explain why some people get stuck in chronic illness. Bob breaks down how everyday exposures, stress, and hidden genetic patterns can overwhelm the body, and shares a fascinating case study showing how personalized insights can reveal why someone isn’t getting better.----Bob Miller is a certified traditional naturopath and a pioneer in the field of genetic-specific nutrition. For more than three decades, he has helped clients uncover how their gene variants influence detoxification, inflammation, and chronic symptoms, and how targeted nutritional support can make a life-changing difference. Bob is the founder of the Tree of Life practice, where he has spent decades connecting the dots between genetics, environment, and stubborn health issues.He is also the formulator behind more than 55 epigenetic nutritional products designed to support enzyme function and healthy detox pathways, widely used by health professionals across the country. As an educator, he teaches physicians and practitioners through national seminars, webinars, and his certification program in genetic nutrition. He also created the innovative MethylGenetic Nutritional Analysis™ software, which blends gene data, labs, and symptoms to craft personalized wellness protocols.Bob is the founder of the NutriGenetic Research Institute, where he leads groundbreaking studies on the relationship between genetic variants and complex conditions such as chronic Lyme disease, research that has been internationally recognized and awarded. His work continues to shape how practitioners understand genes, toxins, and individualized healing.----Bob Miller, CTNWebsite (NutriGenetic): nutrigeneticresearch.orgWebsite (Tree of Life): tolhealth.comLinkedIn: linkedin.com/in/bob-miller-ctn-a0b8021b----Visit www.integrativepeptides.com and use the code PODLIFE to get 10% off your first purchase.----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalkshttps://drtalks.com/podcast-service/

Nov 26, 2025 • 43min
The Perfect PRP: Everything You Need to Know About Platelet-Rich Plasma
PRP: miracle cure or medical myth? Here’s the real story. In this episode of Peptides and Longevity, Dr. Jeffrey Piccirillo reveals why some platelet-rich plasma treatments disappoint while others spark remarkable repair. He also breaks down the small tweaks that can turn an average treatment into a regenerative breakthrough. If you’ve ever wondered why this therapy seems magical for some and useless for others, this episode connects the dots.----Dr. Jeffrey Piccirillo is a board-certified orthopedic surgeon and the CEO and Founder of Regenerative Medical Associates in Florida. After stepping away from surgery due to hand tremors, he shifted his career toward holistic and regenerative medicine, opening The Center for Total Wellness in Iowa. There, he focused on restoring health through intravenous nutrition, targeted supplements, diet modification, and the early development of platelet-rich plasma and stem cell protocols for joint, tendon, and ligament injuries.Dr. Piccirillo began consulting with practices across the country, helping physicians transition from insurance-based models to thriving cash practices while delivering better patient outcomes. He and his team support hundreds of clinics nationwide, offering everything from regenerative products and equipment to hands-on training and marketing support. He also partners with leading innovators to train clinicians in platelet-rich plasma, joint injections, sexual wellness procedures, and other regenerative techniques, making his company a full-service resource for practitioners looking to excel in regenerative medicine.----Jeffrey Piccirillo, DOWebsite: regenmedicalgroup.com----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalkshttps://drtalks.com/podcast-service/

Nov 19, 2025 • 54min
The Anti-Aging Answer: How to Activate Telomerase to Stop Telomere Loss
The secret to healthier aging might be hiding in your chromosomes. In this episode of Peptides and Longevity, Eric McDonald of T.A. Sciences joins us to unpack how people are using their supplements to help preserve telomere length, support immune function, and promote healthier aging.----Eric McDonald brings almost four decades of experience in biology, pharmaceuticals, and regenerative medicine. After earning his biology degree from Michigan State University, he launched a highly successful pharmaceutical career with Parke-Davis, helping bring blockbuster drugs to the market like Lipitor, Lopid, and Cognex. He quickly rose through leadership roles in sales, training, and marketing before later serving as Director of Sales at both Doak Dermatologics and Taro Pharma.In 2013, Eric shifted his focus toward regenerative medicine, a move that reshaped his career and passion. He joined T.A. Sciences as Director of Sales, where he helped grow operations and worked closely with top experts in telomere biology. Today, he is known for bridging his pharmaceutical background with cutting-edge longevity science, helping clinicians and consumers better understand the tools that may support healthier aging.----Eric McDonaldWebsite: tasciences.comLinkedIn: linkedin.com/in/ericmcdonald ----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalkshttps://drtalks.com/podcast-service/

Nov 12, 2025 • 1h 34min
Making the Connection - Looking at Unconventional Patterns to Solve Autoimmune Disorders
Reversing autoimmunity isn’t about chasing perfect lab numbers. It’s about teaching your immune system how to find balance again. In this episode of Peptides and Longevity, Elizabeth Tringali joins us to reveal how small, strategic steps like the right peptides, detox support, and food choices can quiet flares, rebuild energy, and help you feel like yourself again.----Elizabeth Tringali is a Board-Certified Physician Assistant and a Diplomate of the American Academy of Anti-Aging Medicine. A graduate of the University of Florida, she began her career in nutrition science and research with the Women’s Health Initiative, an experience that shaped her lifelong passion for holistic, patient-centered care.Blending her roots in nutrition with advanced training in anti-aging and regenerative medicine, she has spent more than two decades helping patients uncover the root causes of fatigue, hormone imbalance, and autoimmune conditions. Known for combining natural therapies with cutting-edge medical innovations, she creates personalized healing plans that restore energy, balance, and long-term wellness.----Elizabeth Tringali, PA-CWebsite: tringali-health.comInstagram: instagram.com/etringaliFacebook: facebook.com/elizabeth.tringali.2025/LinkedIn: linkedin.com/in/elizabeth-tringali-pa-c-0010a523----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalkshttps://drtalks.com/podcast-service/

Nov 5, 2025 • 56min
An Intro to Biohacking and Psychedelics
In this episode of Peptides & Longevity, Dr. Kent Holtorf speaks with Dr. Sanjeev Goel, a Toronto-based biohacker and longevity expert. They explore how psychedelics, peptides, and data-driven therapies are transforming health, performance, and aging—revealing what’s next in the science of self-optimization.Born in Montreal and now based in Toronto, Dr. Goel’s journey has been far from conventional. With over five decades of lived experience and a résumé that spans remote medical service in Himalayan villages to teaching mindfulness to healthcare professionals, his voice carries both wisdom and credibility. His biological age is a full ten years younger than his chronological one, a living testament to the anti-aging practices he preaches. But his path hasn’t been without hardship. In 2019, a severe Lyme-like illness brought him face-to-face with his own mortality. The experience sparked a deeper commitment to healing, self-exploration, and science-backed rejuvenation.Sanjeev Goel, MDWebsite: https://www.sanjeevgoel.com/ YouTube: https://www.youtube.com/channel/UCVLk0UmBqWSiUU3SFKrFtig Instagram: https://www.instagram.com/drsanjeevgoel Facebook: https://www.facebook.com/drsanjeevgoel/ ----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalkshttps://drtalks.com/podcast-service/

Oct 29, 2025 • 1h 14min
Living Libido Loca! Supercharge Your Libido at Any Age
Reignite your libido from the inside out—no shame, no guesswork. In this episode of Peptides and Longevity, Dr. Valerie Phillips joins us to uncover what really drives desire. She shares how rebalancing your hormones, optimizing sleep, calming stress, and even healing your gut and pelvic floor can reignite libido, naming certain peptides may be the missing piece to bringing your passion back.Loss of desire isn’t a life sentence—it’s your body’s way of asking for balance. In this episode of Peptides and Longevity, Dr. Valerie Phillips reveals how she helps women reignite passion by looking beyond hormones to the deeper story unfolding inside the body. She explores what happens when communication between mind, metabolism, and mood breaks down—and how restoring that dialogue can transform not only energy and confidence, but connection itself.Tune in to hear what most people overlook when libido fades: subtle shifts in stress chemistry, sleep cycles, gut health, and emotional health that quietly drain vitality. Dr. Phillips shares how small, strategic adjustments can unlock a natural return of desire, showing that when your body feels safe, nourished, and rested, passion often follows. The takeaway: it’s not about chasing youth—it’s about rediscovering the spark that balance brings naturally.Valerie Phillips, ND (Dr. Val) is a native Angelino who started studying the medical arts as a teenager in Magnet School. She studied Biochemistry at U.C. Davis, and subsequently pursued research in Neuro-Pathology at U.C. San Francisco. She also volunteered at the Berkeley Free Clinic and at the Native American Health Center in San Francisco, and became a “lay healthcare worker,” delivering limited primary care services to the underserved populations of the San Francisco Bay area. Based on this experience, Dr. Val decided to pursue her long term interest in eastern and alternative forms of Medicine by pursuing a Naturopathic Medical degree at Bastyr University in Kenmore, WA. The education was the perfect blend of western scientific medical thought combined with herbal traditions from across the globe, nutrition, physical medicine and many more disciplines designed to train physicians to see all the aspects of the human body as a holistic unit.Valerie Phillips, NDFacebook: https://www.facebook.com/ValeriePhillipsND----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalkshttps://drtalks.com/podcast-service/

Oct 22, 2025 • 1h 3min
The Underpinnings of Aging and What to Do About It
The secret to living better for longer starts with removing the cells that make you old. In this episode of Peptides and Longevity, Dr. Joe Cleaver pulls back the curtain on senolytics, showing how to clear senescent cells and build you back up with mitochondria, hormones, and targeted peptides.Want to age in reverse? Start by clearing out the cells making you old. In this episode of Peptides and Longevity, Dr. Joe Cleaver reframes longevity around one simple idea, which is that you remove what ages you and then rebuild what keeps you young. He explains how senescent cells accumulate, why they become inflammatory factories, and how fasting and senolytics can clear the backlog. He then shows how to protect and upgrade mitochondria, why telomeres work as a useful marker rather than a destiny, and where peptides belong. The result is a stepwise, precision plan that starts with clearance, moves into cellular energy, and finishes with targeted repair for brain, skin, hair, and whole-body performance. Watch the full episode now and learn how to start clearing the cells that make you old.Dr. Joseph Cleaver is a board-certified internist and fellow in anti-aging and metabolic medicine who blends preventive lifestyle medicine, regenerative therapeutics, and peptide science. He teaches clinicians nationwide and sees patients through the Paradigm Wellness Medical Group. He also hosts small-group masterminds on longevity and regenerative medicine at his winery in Sonoma.Dr. Joseph CleaverWebsite: www.pwmgmed.comIntegrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalkshttps://drtalks.com/podcast-service/

Oct 15, 2025 • 1h 22min
Healing the Sick of the Sick: Inside Dr. Crozier’s Approach
Tried everything and still sick? This protocol could finally move the needle. In this episode of Peptides and Longevity, Dr. Gordon Crozier reveals how he helped patients with complex chronic conditions recover using specific peptides paired with ozone, amino acid therapy, and detoxification strategies that reset the body from the inside out.What happens when even the top hospitals can’t help? In this episode of Peptides and Longevity, Dr. Gordon Crozier discusses how he takes on the ‘sick of the sick’ using a cellular approach that rebuilds health from the inside out. He delves into how he combines peptides with ozone, amino acid therapy, and phosphatidylcholine to help calm neuroinflammation and restore balance where medicine left off. Dr. Crozier also reveals why advanced tests often tell the story traditional tests miss—and how timing, pulsing, and persistence turn short-term improvements into lasting recovery.Dr. Gordon Crozier is the owner and medical director of Crozier Clinic, a leading genetics-based center specializing in peptides, hormone optimization, and advanced diagnostics. A former neurology and neurosurgery clinician, he combines deep neurological insight with personalized, regenerative protocols.As a faculty member and peptide educator for A4M and the International Peptide Society, he has trained hundreds of practitioners nationwide. He’s also the author of Healing One Cell at a Time, Ticked Off, and Heal Your Cells. Save Your Life., and continues to pioneer innovative, compassionate care in chronic illness and longevity medicine.-----Dr. Gordon CrozierWebsite: www.crozierclinic.comInstagram: www.instagram.com/drgordoncrozierFacebook: www.facebook.com/DrCrozierIntegrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalkshttps://drtalks.com/podcast-service/

Oct 8, 2025 • 1h 8min
Secrets to Fatigue, Brain Fog, Mood Disorders, Chronic Pain
This protocol helps even the most sensitive patients move forward. In this episode of Peptides and Longevity, Dr. Christopher Wakely joins us to lay out a roadmap for complex chronic illness that involves opening detox pathways, restoring immune tolerance, and tackling infections and toxins. Watch now to get practical tips on reading basic tests and knowing when to add peptides, neural therapy, ozone, hypercoagulation support, and even strategies for kids with PANS/PANDAS.-----Still stuck? This doctor’s roadmap skips the guesswork. In this episode of Peptides and Longevity, Dr. Christopher Wakely joins us to share a clear plan for tackling complex chronic illness. He explains why treatment must start by ‘opening the drains’ or helping the liver, gut, kidneys, and brain move toxins out. He also shows how simple labs and natural killer cell testing can guide what to treat first, saving time and money.Dr. Wakely also dives into restoring immune balance, using binders safely, and choosing the right tools at the right time. You will hear about drainage remedies, herbs, neural therapy, peptides, ozone, and other strategies designed to help patients heal without big flares. If you’ve felt stuck or flared with every new protocol, this episode is for you.-----Dr. Christopher Wakely is a naturopathic physician and the owner of Aster Integrative Medicine in Edmonds, Washington. Known for helping patients who have seen countless doctors without answers, he specializes in complex chronic illness, including tick-borne diseases, mycotoxin illness, chemical sensitivity, and autoimmune conditions.Dr. Wakely blends the best of conventional and naturopathic care. His approach includes targeted detox and drainage, immune system retraining, herbal and homeopathic therapies, peptides, nutritional support, and, when needed, pharmaceuticals—always to help patients heal safely and sustainably. When he’s not in the clinic, he enjoys life in Seattle with his wife and two daughters, hiking, weightlifting, reading, and cheering on the Boston Red Sox.-----Christopher Wakely, NDWebsite: https://www.drwakely.com/LinkedIn: https://www.linkedin.com/in/christopher-wakely-8a906369/-----Integrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalkshttps://drtalks.com/podcast-service/


