Neurology Minute

Dr. Tesha Monteith, a PACAP biology expert, and Dr. Messoud Ashina, a migraine therapy specialist, delve into the revolutionary role of PACAP in migraine prevention. They discuss a groundbreaking study on a monoclonal antibody targeting PACAP, revealing its crucial functions in migraine triggers. The two also explore PACAP's vasodilatory effects and how intravenous PACAP infusion impacts specific arteries. Tune in for insights on potential new therapeutic approaches that could change migraine management forever!

Dr. Amy Gelfand and Dr. Matthew Bender discuss the possible association between glymphatic outflow and extent of TSS in patients with IIH. Show reference: https://www.neurology.org/doi/10.1212/WNL.0000000000209529

Dr. Tesha Monteith, a migraine treatment expert, teams up with researcher Richard B. Lipton to explore the effects of Ubrogepant on migraines. They dive into a recent study highlighting how Ubrogepant can dramatically enhance patient-reported outcomes during the migraine prodrome phase. With significant boosts in functioning and patient satisfaction compared to a placebo, this discussion sheds light on innovative approaches in migraine care.

Dr. Rae Bacharach discusses the Neurology Today article, "Large Study Finds COVID Vaccination Does Not Increase Multiple Sclerosis Relapses" by Susan FitzGerald, available in the September 5th issue of Neurology Today or at neurologytoday.com.  Show reference:  https://journals.lww.com/neurotodayonline/fulltext/2024/09050/large_study_finds_covid_vaccination_does_not.3.aspx

In the third episode of this three-part series, Dr. Stacey Clardy and Dr. Mary Schroth discuss the critical objective of advancing the quality of life for individuals with SMA in the coming years. Show reference:  https://www.neurology.org/doi/full/10.1212/CPJ.0000000000200310

In this insightful discussion, Dr. David Perez, a specialist in physiotherapy for functional motor disorder, teams up with Dr. Glenn Nielsen, an expert collaborator in treatment efficacy. They delve into a recent randomized control trial comparing specialist physiotherapy to standard treatments. While both methods led to patient improvement, the benefits of specialized physiotherapy emerged in secondary outcomes, highlighting its potential role in comprehensive care for functional motor disorder.

Dr. Stacey Clardy, a specialist in spinal muscular atrophy treatments, and Dr. Mary Schroth, an expert in the latest SMA practices, dive into revolutionary therapies that have emerged since 2016. They highlight advancements that boost survival motor neuron protein production, enhancing the quality of life for patients. The discussion reveals crucial details about patient eligibility and administration methods, showcasing how these innovations are reshaping the management of spinal muscular atrophy.

In the first episode of this three-part series, Dr. Stacey Clardy and Dr. Mary Schroth discuss the most common types of spinal muscular atrophy. Show reference: https://www.neurology.org/doi/full/10.1212/CPJ.0000000000200310 

Dr. Gregg Day, a specialist in Alzheimer's diagnostics, and Dr. Sebastian Palmqvist, an expert on cognitive conditions, delve into groundbreaking advancements in blood testing for Alzheimer's. They discuss a revolutionary blood test that boasts a 90% diagnostic accuracy and a staggering positive predictive value of 95 to 99% for patients with cognitive symptoms. This innovative approach is set to transform how Alzheimer's disease is diagnosed, offering a more precise alternative to traditional methods.

In the second part of this two-part series, Dr. Jeff Ratliff and Dr. Calum Hamilton discuss the clinical criteria that listeners should look out for, indicating a subtype of mild cognitive impairment known as DLB, which could potentially progress into a full dementia with Lewy body phenotype. Show reference: https://www.neurology.org/doi/10.1212/WNL.0000000000209499