Live Long and Master Aging

Eventually, we will all face the challenges that come with old age. We will have less strength and energy than we once had. But what if it were possible to rekindle the drive and physical endurance of youth as we grow older? Prof. Johan Auwerx directs the Laboratory for Integrated and Systems Physiology at École Polytechnique Fédérale (EPFL) in Lausanne, Switzerland, where he studies the mechanisms that control how metabolisms are controlled and the factors that make them more or less effective. Focussing on longevity, his team is using multiple animal species to test a specific compound, Urolithin A, which could potentially restore much-needed muscle strength and energy to people as they age. Prof. Auwerx’s peer-reviewed research, including joint studies with the Swiss life science company, Amazentis, has been published in leading scientific journals. In this LLAMA podcast interview, with Peter Bowes, Prof. Auwerx, discusses the critical need for an affordable solution to ensuring a long and healthy life; how a highly pure form of Urolithin A, known as Mitopure, could be the key to improving our cellular health and strength as we age; and the simple steps we can take to mitigate health issues later in life.This episode is produced in association with Amazentis, which is pioneering cutting edge, clinically validated cellular nutrition, under its Timeline brand.Disclosure: Prof. Auwerx is a scientific adviser to Amazentis and several other companies which make products to boost mitochondrial function. Learn more about the science behind Mitopure, a highly pure form of Urolithin A, from Timeline.Full show notes at the Live Long and Master Aging website.In this interview we cover: The downside of a more sedentary life, either enforced by COVID-19, or as a function of growing old.Why each person’s metabolism functions differently and what this means for our diet.Making the transition from treating patients to medical research.Tackling the big questions regarding metabolic diseases and complex interactions of the human body and the environment. The role of the gut microbiome and genetic makeup in long-term health. Why gaining weight has different implications for the young and old Why people Iiving in one region of the world will digest certain foods more efficiently than people living in a different area.Research with nematode worms (C. elegans) as a model for human aging and longevity.Testing worm observations in human cells, using phenotype data.   How studies on extracts from pomegranates led to a better understanding of Urolithin A.Understanding the difference between healthspan and lifespan. Promoting the benefit of physical activity based onFit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

"Let food be thy medicine and medicine be thy food." The quote, attributed to the Greek physician, Hippocrates, encapsulates the importance of nutrition and the extraordinary ability of certain foods to enhance our wellbeing. In this episode of the LLAMA podcast, we explore the rich array of benefits to be gained from plant foods and natural products and discover why foods rich in compounds known as phytochemicals are hugely beneficial in preventing some chronic conditions. Dr. Navindra Seeram is a professor at the University of Rhode Island, College of Pharmacy.  A leading researcher in the science of plant foods,  Dr. Seeram explains how, growing up in South America, with a tradition of using food as medicine, he first became aware of the potent power of plants.  We delve into the unique components of pomegranate and other fruits, which can be used by the body to boost mitochondrial health.  This LLAMA podcast episode is produced in association with Amazentis, an innovative life science company dedicated to employing breakthrough research and clinical science to bring advanced therapeutic nutrition products to life, under its Timeline brand.Disclosures: Dr. Seeram serves on the scientific advisory board of Amazentis, independently from his position with the University of Rhode Island.  In this interview we cover:Growing up in British Guiana, a poor Third World country, learning about the power of plants as medicines. Developing a career as a natural product chemist.Understanding the anthocyanins or the pigments which make cherries red, blueberries blue, strawberries red and pomegranates red.Defining phytonutrients and phytochemicals.Deriving drugs from natural sources like plants.Revealing the multi-layered qualities of the pomegranate.Trillions of gut bacteria and why they are vital to the way we function.The importance of urolithin A as one of the metabolites we get from pomegranates.Understanding why we respond in different ways to the potentially beneficial compounds found in fruits. Being a responder or a non-responder to Urolithin A.Linking urolithin A to mitochondria - the powerhouse of the cell.  Mitopure™ -  a highly pure form of Urolithin A - and why it has the potential to “cut to the chase,” even for non-responders.Personalized nutrition and precision medicine. Simple diets, spices, coffee and red wine. Healthspan science, long-term wellbeing and reasons to keep on living. The Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

The art and science of aging well is a complex business - a nuanced melding of a finely tuned diet, essential exercise and a healthy mind. For over twenty years, Prof. Luigi Fontana has been studying the lifestyle regimes that could help us live a longer, healthier life. One of the world’s leading experts in the field of human longevity, Dr. Fontana, a physician and professor of medicine and nutrition at the University of Sydney, takes a pragmatic approach to the aging process, railing against aspirations to live an excessively long life. The author of ground-breaking research on fasting and nutrition, he explores the wider issues involved in the aging process in a new book, The Path to Longevity: The Secrets to Living a Long, Happy, Healthy Life. In this LLAMA podcast interview, with Peter Bowes, Prof. Fontana argues that medical systems based on treating sick people should be replaced by a more holistic approach to the human body. He also philosophizes about life's "beautiful journey.” In this podcast we cover:Working as a longevity scientists in Australia, a country with free healthcare.The difference between healthcare and sick care. Like unserviced cars, how unhealthy humans are accidents waiting to happen."The scourge of obesity, especially in children and the relationship with chronic disease.  Why living longer by itself is of "no importance"  Finding happiness and harmony in life.The environmental impact of high protein and keto diets.Living long thanks to the longevity gene? The craziness of magical recipes to live longer. The metabolic and molecular pathways that regulate the accumulation of damage.  Calorie restriction (CR) - the most powerful intervention to slow aging.Getting a phone call from CR pioneer Roy Walford. The confusion of ‘intermittent fasting’ describing multiple, disparate regimes.  The limits of using mice and other animals as models for humans in longevity research. The role of IGF-1 - Insulin-like growth factor 1.The 5:2 diet and what we eat on those non-fasting days. Developing biomarkers that measure our response to interventions focussed on improving health.The importance of waist circumference.  The ‘religious’ extremes of longevity - vegetarians, vegans, carnivores.  Approaching aging like a master conductor or a fine artist. A lack of exercise being the main public health problem of the 21st century. Why sportsmen and women do not live particularly long lives. The role of the matters of mind in longevity and pink noise. The value of sleep in healthy aging and memory conso PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarFit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

This episode of the Live Long and Master Aging podcast is the first in a series produced in association with the Swiss life science company, Amazentis.  It will explore the history of the company and the science behind its goal of promoting healthy aging. Professor Patrick Aebischer, chairman and co-founder of Amazentis, is a medical doctor, neuroscientist and longtime researcher.  He has held distinguished positions in his home country of Switzerland, as President of the École Polytechnique Fédérale de Lausanne (EPFL) and in the United States at Brown University in Providence.  In this interview we explore how an idea based on little more than “intuition” led to a deeper understanding of muscular strength, as we age, and the role of fruits such as pomegranates. We focus on urolithin A, a bioactive dietary metabolite that is naturally produced when eating certain foods, and how Mitopure, a highly pure, synthetic form of the compound, could help people avoid frailty as they grow older.▸ This episode is produced in association with the Swiss life science company, Amazentis, which is pioneering cutting edge, clinically validated cellular nutrition, under its Timeline brand.▸ Published: Jul 8, 2020 ▸ Read a transcript and additional show notes at the Live Long and Master Aging (LLAMA) podcast website ▸ Also listen and subscribe at Apple Podcasts and You Tube.▸ Listen to related episodes exploring the science behind Urolithin A and MitopureDISCOUNTS▸ Time-line is offering LLAMA podcast listeners a 5% discount on its Mitopure products - Mitopure Powder, Softgels and Mitopure + Protein. Use the code LLAMA at checkout.▸ DoNotAge.org is offering LLAMA podcast listeners a 10% discount on its range of products – NAD boosters, Sirtuin activators, senolytics and more. Use the code LLAMA during checkout at DoNotAge.org  Any health queries can be answered by emailing the team at hello@donotage.org.The Live Long and Master Aging podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

We are bombarded with advice and information about diet and exercise, but what about the impact of friendship, optimism and kindness on our longterm wellbeing? It is eye-opening to discover that a strong support network of family and friends lowers mortality risk by about 45 percent, while volunteering your free time reduces the chances of early death by a staggering 20-60 percent, depending on the study. Science journalist Marta Zaraska is the author of Growing Young: How Friendship, Optimism and Kindness Can Help You Live to 100. In this episode of the LLAMA podcast, she discusses the peer-reviewed studies that suggest living to a great age is about more than what we eat or how much we move.  We cover how caring for children motivates us to keep on living and why Marta's long-held beliefs about aging and longevity were shattered through an understanding of the research. Check out our website at LLAMApodcast.com and social media sites @LLAMApodcastIn this episode we cover: Coping with Covid-19 in France, where the outlook is looking better, with no second wave of the virus yet.Becoming a mother and thinking more about health and longevity. Why fixating on nutrition and exercise does not tell the whole story. Delving into the science behind friendship, optimism and kindness. What “Growing Young” means.The folly of “anti-aging."Why hugging and cuddling is good, most of the time.The extremes some people go to for human contact.The blood science that validates acts of kindness as a positive behavioral trail. Oxytocin, serotonin and endorphins. The science behind that fuzzy warm feeling.  PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarFit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

How many times have you heard about an older person doing extraordinary things, despite their great age? In recent weeks the story of the 100-year-old war veteran, Captain Tom Moore, has captivated millions, for his marathon fund raising efforts in the UK. Walking lengths in his garden he has raised more than £30m for the National Health Service, during the Covid-19 crisis. He is amazing. In this episode of the Live Long and Master Aging podcast we explore the lives of amazing people through the eyes of Dr. Noelle Nelson, a California-based psychologist, author of Happy, Healthy...Dead and collector of eye-opening stories through her Facebook page, Meet the Amazings. What are the common traits of older people who live their lives to the full, almost to the end? In this interview we cover:Aspiring to be to be happy, healthy, dead. The lives of the very old - ordinary people doing extraordinary things.Compressed morbidity - reducing the time it takes for the final exit. Why most of Dr. Nelson's longevity achievers are not famous.Joining the dots and connecting the common traits of people who reach a great age. Positivity or optimism: Why it is a major predictor of happy healthy longevity.A passion: From growing tomatoes to looking at the starsA purpose: Sharing knowledge or the joy of competing - in ballroom dancing. Physicality: Walking, climbing, dancing - how exercise has been shown to improve mind and body functioning. The power of always looking forward. The value of friends - or “anchors" - to get through life’s tough times. Dealign with losing everything in one of California’s wildfires. The value of please and thank you and self appreciation. Exploring science-based lifestyle interventions to live better.Editor’s note: This episode of the LLAMA podcast was recorded in Camarillo, California, on February 27th, 2020, three weeks before the state became the first in the U.S. to issue a stay at home order due to the coronavirus.The Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.   PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarSupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

We are in the war against Covid-19 for the long term. The virus is likely to be with us for many months, if not years, and as we emerge from the global lockdowns, everyday life is looking very different. Re-imagining a post-coronavirus world will likely involve changes that go to the heart of how we live - our diet, personal hygiene, social behavior and work/life balance.  As we learn more about the virus, it is becoming clear that a healthy body is a vital prerequisite to fighting the disease.  In this episode of the Live Long and Master Aging podcast, Dr. Aseem Malhotra, a London-based cardiologist, explains why he believes obesity is a prime risk factor for mortality from Covid-19.  He also suggests that the pandemic should act as a wake-up call for global populations, pursuing unhealthy lifestyles, consuming too much sugar and processed foods.Dr Aseem Malhotra is a National Health Service (NHS) Consultant Cardiologist in the UK, and visiting Professor of Evidence Based Medicine, Bahiana School of Medicine and Public Health, Salvador, Brazil. In the episode we cover: How a "horrendous state” of baseline general health, in many western populations, is relevant to Covid-19Ref. European Scientist: Covid 19 and the elephant in the room (April 16, 2020)The myths surrounding the health of people in Mediterranean countries. What is optimal metabolic health? Blood pressure, waist circumference, blood triglyceride, HDL, and HbA1c levels.Nature:  Endocrine and metabolic link to coronavirus infection (April 2nd, 2020)Lifestyle lessons from Covid-19.Personal hygiene and why it matters. Imagining the post-coronavirus world.  Listen to Dr. Malhotra’s previous LLAMA podcast interviewEpisode 03: Waging war against sugarThe Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor. PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarSupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

There are some encouraging signs around the world that the Covid-19 curve is flattening in some places, while falling in others. During the course of this pandemic we are focussing, on this podcast, less on longevity and more on our immediate futures. But as life slowly evolves towards a new normal, there are many lessons to be learned from the pandemic and the role science plays in our lives. In this episode we catch up with Prof. Valter Longo, director of the Longevity Institute at the University of Southern California and director of the Longevity and Cancer Program at IFOM Institute of Molecular Oncology in Milan in Italy. The Italian scientist splits his time between his home country and the United States, both badly affected by coronavirus.  In this episode we discuss the role of scientists working alongside doctors, sharing advice on how to behave during the outbreak. We also discuss the implications for people following a fasting mimicking diet, during a time when the risk of infection by the virus is high. Earlier LLAMA podcast conversations with Prof. Longo:March 7, 2017: Creating the fasting mimicking dietJanuary 16, 2018: Living to 110 on a science-based dietIn this interview we discuss:Personal insights into the progression of coronavirus in Italy and the United States.The debate over the use of chloroquine to treat patients with Covid-19.Was time wasted in the US through the lack of advice to wear masks in the early stages of the outbreak?Speculation on why California has significantly few cases than other large population centers in the US. The work of Dr. Longo's Create Cures Foundation, including education and work to combat childhood obesity. Geographic differences in the spread of coronavirusHelping front-line health workers treating patients with coronavirus.  The power of scientists and doctors working together as a team.Is it safe to go on a diet, or fast, during the coronavirus outbreak?Latest news on the Fasting Mimicking Diet and new clinical trials.The Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.   PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarSupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

The coronavirus pandemic is threatening every facet of normal life. This episode of the LLAMA podcast was recorded before the global health crisis hit home for so many of us. It focusses on the work-life initiatives of a rapidly growing US company that could be a blueprint for how we live in the future.  But not until life returns to normal. VideoAmp founder and CEO, Ross McCray, is currently dealing with the huge challenge of running a software and data company, employing more than 230 people, from home. He is particularly focussed on providing employees with support for their general wellbeing, to match the facilities that they usually enjoy at the office. Ross is on a long-term mission to change the work-life paradigm. He wants to build a workplace model that nurtures the physical and mental fitness of employees, in an environment that prioritizes happiness and health span. This episode includes Ross’s original interview, with LLAMA’s Peter Bowes, and an update on the impact of coronavirus. In this interview we cover: Is there a blueprint or formula for best workplace practices that you can incorporate to other companies to make people truly happier and more effective?Being highly energized throughout the day.Providing workplace 24/7 gym facilities, personal training, healthy food, mental health support. Effectiveness and longevity during the working day. Work-life harmony - a nuanced approach to a fluid lifestyle.Different lives, priorities and perspectives on life.Balancing schedules - from medical appointments to office meetings and being a parent.Clear, measurable goals and flexible work-time.Physical challenges, weight loss and muscle building, at work.A data driven approach to a new workplace model focussed on wellbeing.  Coronavirus update:Dealing with the everyday changes due to the coronavirus crisis. Adapting to a home-working environment with improvised gym equipment. Streamed workouts for virtual meetups to boost morale and maintain fitness.Dealing with the uncertainly and unease. Rising to the occasion with inspirational quotes and “uplift vibes” through company playlists.  PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarFit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Coronavirus is the only topic on our minds at the moment. People are panic shopping, a national emergency has been declared in the United States and widespread travel bans have been implemented around the world. There is also much confusion over testing for Covid-19 and how we should be looking after ourselves as the pandemic unfolds. Living long and well may be our goal in normal times, but getting through the next few months is a greater concern right now. In this episode of the Live Long and Master Aging podcast, with Peter Bowes, Dr. Felice Gersh, a physician and integrative medicine specialist, discusses the practical implications of a disease that has gripped the world with fear and uncertainty. In this episode we cover:Coronavirus: the global threat and our response to it. The impact on doctors’ surgeries and the rise of telemedicine.Social distancing - what it means and how to achieve it.The implications of a viral pandemic for dietary regimes - whether they be for weight-loss or longevity.Fasting, the immune system and eating to stay healthy.Surviving at home or in isolation.Are men and women equally vulnerable to coronavirus?Going into emergency mode and maintaing best health practices.Exercise regimes during a health crisis. Calming the mind and dealing with the stress.Seeing beyond the crisis and helping each other.The Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind you should consult your own doctor or professional health adviser.  PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarSupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.