Inside Health

Statins have dominated the cholesterol-lowering field for some years but last week the results of an international trial of Evolocumab, one a new breed of medicines for reducing cholesterol, was hailed as a breakthrough. Professor Peter Sever, one of the leaders of the trial, explains how Evolocumab differs from statins and Dr Margaret McCartney takes a look at the trial.You may have noticed them in work places, gyms, and other public spaces but do you know how and when to use a defibrillator? Every time someone has a cardiac arrest and CPR is performed we should also be running for the nearest defibrillator. But currently this only happens in 2-3% of cardiac arrests, putting thousands of lives at risk every year. Mark speaks to teacher Erica Melsom and the pupil, Alex Cowes, whose life she saved by using the school defibrillator. Professor Gavin Perkins explains why and when we should run and get one. And Mark demonstrates just how simple they are to use, even if you've never touched one before.Posttraumatic Stress Disorder, a psychological condition which can begin after a traumatic event and last for many years, is the equivalent for your cardiovascular system of smoking 10 cigarettes a day. Dr Donald Edmondson explains how extreme stress takes a toll on our arteries.More than 80% of pregnant women take at least one prescribed medication and yet very few of these drugs are actually licensed for use in pregnancy. Mark talks to Professor Anna David about why there has been a reluctance to license medications for use in pregnancy, what impact that has for pregnant women, and what needs to change.Producer: Lorna Stewart.

Clarification of new evidence that Bisphosphonates for osteoporosis may actually weaken bones if people are left on them for too long ; Dietary change using FODMAPS to treat Irritable bowel syndrome when medicines have not worked; CRP testing for chest infections to identify which need antibiotics; And Mark eats humble pie for getting clinical terminology mixed up.

More than 6500 people are currently on the national transplant waiting list, hoping for an organ to be donated which might save their lives. Many of them will wait for years and, sadly, hundreds will die before a suitable organ becomes available. The low supply of organs remains the main restriction on performing lifesaving transplant surgery. The British Medical Association believes that moving to an opt-out donation system - where people who die without expressing whether or not they wish to donate their organs will be presumed to be willing to donate - would increase donation rates and save lives. The system has been in place in Wales since December 2015 and now the BMA says it's time the rest of the UK followed the Welsh model. Dr Margaret McCartney discusses with Dr Phil Banfield, chair of the British Medical Association Welsh Council. An area of medicine not often discussed on Inside Health is pathology. Mark visits the morgue at St Mary's Hospital in London to speak to pathologist Mike Osborn. What happens to your body after death? What is rigor mortis? And how much do crime dramas on TV get right?Finally, what time of day should you be taking your blood pressure medication? Millions of people take drugs to control their blood pressure and reduce their risk of heart attacks and strokes. Most people will take their medications in the morning but with many heart attacks and strokes happening during nighttime hours, just when the medication might be wearing off, should we be considering evening dosing instead? A new online trial has enrolled 21,000 people and aims to find out what time of day is best to take blood pressure medications. Mark speaks to Dr Amy Rogers from the University of Dundee who is in charge of the trial.Producer: Lorna Stewart.

New moves to test pregnant women for smoking by measuring carbon monoxide on their breath. How helpful are lifestyle targets like 10 portions of fruit and veg or 10, 000 steps a day? The incidence of thyroid cancer has tripled in 40 years, but many of the tumours picked up are on scans for something else and may never have caused harm. Mark Porter debates the issues. Plus this week's uncertainty question for Margaret McCartney and Carl Heneghan, to floss or not to floss?

Vitamin D , the sunshine vitamin, has been in the news again with claims that supplements could help ward off coughs , colds and flu. Dr Margaret McCartney takes a look at the study that generated the headlines.Whether or not a severely injured person will receive blood products at the scene of an accident depends on which air ambulance service they are attended by: some air ambulances replace lost blood with red blood cells, but others replace only with saline solution. Evidence from military casualties in Afghanistan suggests giving blood before patients reach hospital leads to better survival rates, but evidence from civilian populations in the UK is less clear. A new randomised controlled trial, being conducted by six air ambulance services, will investigate which course of action has the best outcomes for patients. Mark visits the Midlands Air Ambulance to hear more from lead investigator and trauma anaesthetist Dr Nick Crombie and critical care paramedic Jim Hancox.Phantom limb pain - pain in an amputated limb - is a common complaint among amputees. Pain medication rarely solves the problem and there is is no known cure. But now a trial in Sweden is using augmented reality to help patients relearn how to move their missing limb, and showing that chronic pain can be reduced. Mark talks to lead researcher Dr Max Ortiz.And Margaret McCartney takes a look at the evidence for that dinner party favourite - the sitting-rising test - which proponents have claimed can predict how long you might live.

A special debate on the current state of the NHS. Recorded in front of an audience at the BBC Radio Theatre London.The last few months have seen the service creaking under unprecedented demand, and there is likely to be worse to come. Something needs to give. Is it simply a matter of more resources, or do we also need to change our expectations of what the NHS provides? Is rationalisation and rationing the way forward?Dr Mark Porter discusses the issues with a panel including Clare Marx, president of the Royal College of Surgeons, Chris Hopson, chief executive of NHS Providers, David Haslam, chair of NICE, Prof Sir Nick Black, London School of Hygiene and Tropical Medicine and regular contributor Margaret McCartney GP. Issues discussed include whether the NHS should continue to be free at the point of use. Is there too much bureaucracy with too many bosses? Was the internal market evidence based, has it worked and was it fair? Rationing of treatments. And can the NHS be taken out of politics? Inside Health listeners set the agenda by emailing the programme - some of whom joined the audience - so thank you for all your input. Margaret McCartney writes: The NHS is never far from the headlines, but the last few months have depicted a service in crisis. It's been made clear that there will be no more money from central government - so what needs to give? Clare Marx, explained the angst of her members who wanted to operate on people but had been forbidden to. Nick Black, discussed the types of surgery that were now being placed off limits - like hip replacement surgery - even though they were very cost effective. Because of the way hospitals are funded, it is these useful operations that are being stopped rather than the much less cost effective prescription of some very expensive cancer drugs. Chris Hopson described tensions between the expectations being placed on the NHS to provide excellent care despite the funding gap to actually provide it. And David Haslam, chief executive of NICE, expressed his disquiet that patients could no longer expect a consistent service across the NHS. Instead, different Clinical Commissioning Groups decided themselves how many rounds of IVF to fund, for example. The result was a patchwork of provision, and was inherently unfair. Is rationing therefore the way forward? Some listeners had emailed in suggesting that the NHS shouldn't fund treatments for 'smokers, drinkers and the obese'. Others that people should pay for hospital meals, or there should be a charge made for GP consultations. We already have charges for some things - for example, prescriptions in England, or dental check ups for many people - but as Clare Marx pointed out, removal of teeth is the commonest childhood operation, so can we really say this policy has been successful? I don't believe that we have the evidence to show this is safe: the bureaucracy would be sizeable - I had to sign 12 bits of paper for a routine check when my kids and I last went to the dentist - and then there are unintended consequences. Paying for appointments turns us in to consumers - would doctors feel obliged to give us treatments that people want, even when they don't work well, aren't cost effective or do net harm? Listeners wanted to know if the NHS was over managed - and had strong opinions on how much could be saved if we got rid of middle managers in particular. But Chris Hopson pointed out that we spend less than the very efficient Germany on hospital managers, and Clare Marx said that hospitals are highly complex places needing a huge amount of organisation to run smoothly. For me it is a question of what managers are doing - is it of value to patients, or is it a waste of time?Nick Black argued that there was a great deal of waste still in the NHS - and suggested that the internal NHS market may have had some advantages to start off with, but now, the 4.5 billion a year estimated to be spent on it could be better used elsewhere. There is no doubt that the process of bidding and judging for commissioning costs time and money, but how to stop the problem of bad and wasteful policy in the first place? Could politics be taken out of the NHS? I was on my own, arguing that party politics had done avoidable harm to the NHS and that cross party working - as we see in the Health Select Committee and the National Audit Office - was possible. My fellow panellists argued that since the budget of the NHS was such a large amount of money it would be impossible to disentangle it from politics: but Chris Hopson pointed out that defence spending, for example, was ring fenced. The audience overwhelmingly voted to be taxed more to pay for the NHS. If we were sure that extra money would go on human level care, and not wasteful, non evidence based policy making, I would support it completely. But we are not, as a population, being given that option.

Prescriptions for over-the-counter items cost the NHS millions each year; in 2015 paracetamol prescriptions alone cost £87.6 million. Mark talks to Paula Cowen, medical director at Wirral CCG, one of a growing number of Clinical Commissioning Groups that are asking GPs to restrict prescribing of these items, and to Andrew Green, a GP and the prescribing policy lead at the BMA, who has reservations.Virtual Reality is being harnessed to help people recover from serious brain injury following accidents or strokes, and in conditions like Parkinson's disease and dementia. Mark visits a clinic in Salford where they're using virtual reality in neuro-rehabilitation.And treating sore throats with antibiotics. Sore throats are common accounting for 1.2 million GP consultations every year in England alone - and they affect many millions more who don't see their doctor. Most are viral and self-limiting, but around 1 in 10 are caused by a bacteria and may benefit from antibiotics. The tricky bit is telling the difference between the two but a new pharmacy-based test and treat initiative may help. Mark speaks to Peter Wilson, one of the authors of the pilot study, and Margaret McCartney is on hand to examine the evidence.

Hernias, hands and varicose veins might not be treated on the NHS as such interventions are now on the 'not normally funded' list. This list is where local commissioners show what they are not prepared to pay for, unless circumstances are exceptional. Such prioritising is also known as rationing. Dr Mark Porter investigates if this new layer of bureaucracy is a cost effective use of resources or just delaying inevitable operations with the possible risk of creating emergencies that could cause harm.

Are preventable deaths in hospitals a good measure of the quality of care being offered to patients? It's estimated that there are 12,000 deaths a year in hospitals which could have been avoided, but what does that mean and should we be worried that that number could rise with the NHS under pressure?Mark Porter visits a 'poo bank' in Portsmouth where donated faecal matter is being frozen and stored for later use in patients with Clostridium difficile or C. diff.And midwife Mervi Jokinen and our own Margaret McCartney take a look at the evidence for waterbirths. Is giving birth in water less painful? And is it safe?Producer: Lorna Stewart.

Do funding requests hinder surgery on the NHS? GP referrals to specialists for common complaints are checked by a panel to make sure they're appropriate, but can the admin for funding requests be more costly and time consuming than the operation itself? Mark Porter meets an eye specialist in Reading who argues that it can. Plus a new genetic test that has been developed to identify women at risk of breast cancer more accurately. And lactose intolerance: there's a burgeoning number of lactose-free ads and products in the shops, but is need driving the market - or marketing driving the need?