

The Big Brain Podcast
The Block
The Big Brain Podcast features conversations with crypto's most influential thinkers, builders, and traders.Co-hosted by The Block CEO Larry Cermak and MegaETH CSO Namik Muduroglu, these interviews challenge ideas, dig into mental models, and push guests beyond the headlines.This show isn't about predicting the future of crypto—it’s about spotlighting the big brains shaping it.
Episodes
Mentioned books

Oct 14, 2025 • 45min
Breaking down crypto's biggest ever liquidation event with Wintermute founder Evgeny Gaevoy
Evgeny Gaevoy, Founder and CEO of Wintermute, dives into the recent crypto market turmoil, explaining how extreme leverage and forced liquidations caused chaos on October 10th. He details the mechanics of ADL and how it impacted traders, while discussing the potential of circuit breakers to mitigate future risks. Evgeny also analyzes why major cryptocurrencies like BTC and ETH showed resilience, and shares insights on how market makers adapt to constant volatility. His reflections on Wintermute's role in this landscape highlight both challenges and opportunities.

Aug 25, 2025 • 41min
Venture trends, regulatory wins, and consumer innovation: Tom Schmidt and Alok Vasudev on crypto's new era
In this episode of the Big Brain Podcast, Larry and Namik are joined by Dragonfly's Tom Schmidt Alok Vasudev of Standard Crypto. They dive into current trends in venture capital within the crypto space, touching on how market conditions have evolved since 2021, the role of treasury companies, and the evolving regulatory landscape.
OUTLINE
00:00 Introduction 01:06 Alok's Background 04:45 Tom's Background 06:21 Cap Table Competition 07:53 Crypto 'Metas' 13:09 Copycat Crypto Projects 15:26 Brand Positioning 17:45 Web3 Moats 19:29 Crypto Treasury Companies 27:28 Regulatory Tailwinds 30:38 Consumer Adoption
GUEST LINKS
https://x.com/tomhschmidt
https://x.com/AlokVasudev
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Aug 7, 2025 • 1h 4min
How the US buying Bitcoin will rebuild American strength
Jack Mallers recounts his bitcoin journey, and explains how the US government could expunge its debt by dumping USD into gold and bitcoin.
OUTLINE:
00:00 Introduction
06:55 Mallers Family Office
09:50 Founding Strike
14:53 Orange-Pilling El Salvador
22:23 Bitcoin & Tether
26:18 International Bitcoin Policies
32:39 US Bitcoin Policy
53:30 Twenty One

Jun 23, 2025 • 49min
Infinite Money Glitch: Paolo Ardoino shares Tether's vision for building a stable society
In this episode, Paolo Ardoino delves into the factors that contributed to Tether’s USDT becoming the world’s largest stablecoin. Additionally, Ardoino discusses Tether’s strategic investment in AI, energy, biotech, and other industries, showcasing their long-term vision.
OUTLINE:
00:00 Introduction
00:30 Paolo's Background
1:21 Tether's Path to Success
04:04 Stablecoin Policy
07:23 USDT Adoption in Emerging Markets
12:15 Tether Gold
16:30 Tether & US Hegemony
21:25 Responsible Crypto Education
22:54 Tether Wallet Development Kit
25:00 Chain Preferences
28:52 Tether's Investment Strategy
45:13 Infinite Money Glitch
SHOW LINKS:
Apple: https://apple.co/43F3vmq
Spotify: https://spoti.fi/44NT1lZ
Larry: https://x.com/lawmaster
Namik: https://x.com/NamikMuduroglu
The Block Podcasts: https://x.com/TheBlockPods
GUEST LINKS:
Paolo: https://x.com/paoloardoino
Tether: https://tether.io/
Tether USDT: https://tether.to/
Tether Gold: https://gold.tether.to/
Holepunch: https://holepunch.to/
Keet: https://keet.io/
Wallet Development Kit: https://wallet.tether.io/

Jun 11, 2025 • 50min
DeFi Wizards: Rune Christensen and Guy Young on the past, present, and future of finance
In this episode, Guy Young & Rune Christensen discuss the evolution of DeFi, noting how it has become more grounded in reality and sustainable business models, moving away from the early hype and ideological claims.
OUTLINE:
00:00 Introduction
01:23 DeFi Ain't What it Used To Be
08:27 Ethena's Success
13:01 Get $HYPE(D)
15:08 HL L1
16:38 'Ecosystem Protocols'
19:32 DeFi User Capture
21:42 DeFi Endgame
22:05 Hyper-rational Users Onchain
24:53 Compressing DeFi Rates
27:16 Stealing from the Rich
28:43Onchain KYC
30:57 Forking DeFi
33:57 The Future of Finance
37:50 'MicroStrategy Playbook" for Alts
42:19 Bitcoin DeFi?
43:57 F.A.F.O. Onchain
SHOW LINKS:
- Apple: https://apple.co/43F3vmq
- Spotify: https://spoti.fi/44NT1lZ
- Larry: https://x.com/lawmaster
- Namik: https://x.com/NamikMuduroglu
- The Block Podcasts: https://x.com/TheBlockPods
GUEST LINKS:
- Rune: @RuneKek
- Guy: @gdog97_
- Sky: https://sky.money/
- Ethena: https://ethena.fi/

May 23, 2025 • 1h
Winning the Crypto Long Game
The Big Brain Podcast is co-hosted by The Block CEO Larry Cermak and MegaETH CSO Namik Muduroglu.
In this episode, Haseeb Qureshi & Jordi Alexander discuss the similarities between poker and crypto, the economics of bitcoin's endgame, the intersection of AI and crypto, and more.
OUTLINE:
00:00 Introduction
02:25 Similarities between Poker & Crypto
06:33 Maintaining Crypto Conviction
12:40 Surviving the FTX Fallout
17:55 FTX Marketing Spend
24:05 The Trump Era of Crypto
26:34 Bitcoin Endgame Economics
34:32 Crypto & AGI
43:07 Analysts vs. LLMs
47:47 Market Making & AI
51:52 F.A.F.O. Onchain
SHOW LINKS:
- Apple: https://apple.co/43F3vmq
- Spotify: https://spoti.fi/44NT1lZ
- Larry: https://x.com/lawmaster
- Namik: https://x.com/NamikMuduroglu
- The Block Podcasts: https://x.com/TheBlockPods
GUEST LINKS:
- Haseeb: https://x.com/hosseeb
- Jordi: https://x.com/gametheorizing
EPISODE LINKS:
- AI 2027: https://ai-2027.com/
- Noise: https://www.noise.xyz/
- Dave White Thread: https://x.com/_Dave__White_/status/1866497496773804434

May 20, 2025 • 13sec
The Big Brain Podcast: Teaser
It's gonna be a big show.