Talking Biotech with Dr. Kevin Folta

How do new drug applications move forward to approval?  Four experts discuss the partnership between the FDA, the drug developer, and the data needed to move a product forward. It is a surprising discussion that reveals the depth of the FDA process.  Joined by Dr. Debra Webster, Dr. Julia Marre, Dr. Michael Matthews and Dr. Jonathan Helfgott. 

We live in amazing times of technological advance, but how are the real benefits of new tech lost to an inflated sense of risk?  Dr. Felicia Wu from Michigan State University shares her expertise in describing the psychological basis of risk and applying it to questions like glyphosate and aspartame. 

This is an update on the American Chestnut Restoration Project, as discussed previously on the podcast. The American Chestnut dominated the forests of Appalachia until an imported fungus destroyed the entire range. Efforts to restore the chestnut and its ecology have employed a biotechnology approach, integrating a gene from wheat that limits the mechanism the fungus uses to attack the tree. Dr. Andy Newhouse and Erik Carlson join the podcast to discuss progress in the project.  

Despite being over half of the population women's health care lags behind other areas of drug development. The problem is caused by many facets, but is augmented by the fact that many of the conditions are not life threatening or are functions of aging. Sabrina Johnson, CEO of Daré Bioscience, discusses how the disparity exists, the pipeline of drugs that seek to mitigate female-specific conditions, and how smaller, leaner businesses can have significant impacts in this space. 

The podcast discusses biotechnology innovations, collaborations with pharmaceutical data management software companies, panel discussions on business dynamics, debunking anti-GMO claims, advancements in gene therapy, and technological solutions in the citrus industry.

After 8.5 years of weekly podcasts I'm going to take a 5 week break and plan new episodes for 2024.  I'm going through a medical glitch that has me unable to do my normal work. On top of this we're going to switch to an audio plus video format to find a wider audience. So check back in 2024 for the next episode. Have a great rest of 2023, thank you for listening, and looking forward to better times. 

Todd Hauser, Founder of Trillium Ag, discusses his company's novel RNAi approach to crop protection. They use RNAi to target specific insect species, offering safety, effectiveness, and specificity. The podcast explores the use of RNAi in crop protection, challenges of stability and delivery, and Trillium's innovative approach using nanoparticles and aptomers. They highlight their progress in achieving biological activity in lepadoptera and fall armyworm.

There is tremendous variation in the plant kingdom, as plants have adapted to many ecological niches with discrete challenges. Part of adaptation is production of novel secondary metabolites, compounds not required for central metabolism that serve a role in the plant, such as defense or attraction of pollinators. The rainforest is replete with unusual plants and their resident metabolites. Indigenous peoples have identified therapeutic qualities of specific plants. How can this knowledge be transferred to aid those suffering beyond the rainforest? Lisa Conte is the CEO, President and Founder of Jaguar Health, a subsidiary of Napo Pharmaceuticals.  We discuss process of working with indigenous peoples to learn from their findings, then test and validate them in ways to identify novel mechanisms of action for use in modern medicine. 

Dr. Emma Kovak, a gene editing expert, discusses the proposed changes in gene editing regulations in the EU. She highlights the economic loss caused by the rejection of technology and the need for regulations that do not differentiate between gene editing and conventional breeding. The chapter also explores the potential risks of early breeding and the importance of safe use from traditional breeding.

Information has been weaponized, and the ability to create false information to achieve an ideological goal has never been more easy. Political polarization, science denial, and a shining, effective conduit of dissemination (the internet) allows anyone with an agenda to recruit the like minded, and produce compelling media to reinforce bankrupt ideas. Where did information warfare originate, what are its effects, and how do we fix it?  This week's podcast discusses the book, On Disinformation: How to Fight for Truth and Protect Democracy with author Dr. Lee McIntyre. The book presents a chilling description of who creates disinformation, how subscribes to it, and its long term effect on free society. Fortunately, solutions are proposed that can help curb the penetration of disinformation, particularly as it becomes more effective through artificial intelligence.