Almost a decade ago, the biochemist Jennifer Doudna and her team at Berkeley figured out how to rewrite our genetic code using a system called CRISPR. Thanks to this miraculous discovery, we now have the power to hunt down cancer cells, deflect oncoming viruses, and cure genetic diseases. But CRISPR has a dark side, morally speaking. In a world where we’ll soon have the power to endow our kids with superior strength and intelligence, how far is too far? Doudna’s groundbreaking discovery and the moral dilemmas that followed are the subject of a new book by best-selling biographer Walter Isaacson. In this expansive conversation, he tells Rufus why the CRISPR era will be far more consequential than the digital revolution. Plus, they discuss the mechanics of creativity, the delicate balance between competition and collaboration, and the personality traits that Isaacson’s subjects — Doudna, da Vinci, Ben Franklin, Einstein, and Steve Jobs — all have in common.

What’s for dinner? How will we answer that question in 50 years? In this thought-provoking (and occasionally hunger-inducing) conversation, science journalist Amanda Little tells Rufus that the single biggest threat posed by climate change is the collapse of our food systems. Provisions we love, like coffee and wine, are losing their flavor. And crops we rely on, like corn and soy, are getting harder to grow. If we don’t change our agricultural practices, we won’t be able to feed the globe’s swelling population. But don’t lose hope. Amanda says that if we can combine the wisdom of traditional farming practices with radical advances in agricultural technology, we might be able to create a healthier, more sustainable, and perhaps even more delicious future.

Whether or not we care to admit it, we all talk to ourselves. A lot. The voice in our heads yaks it up about half the time we’re awake, and it can speak at a rate of 4,000 words per minute. When it really gets going like that, not everything it says is particularly helpful. We’ve all gotten stuck dwelling on the past, worrying about the future, or standing idly by as our inner monologue devolves from introspection into negativity. Experimental psychologist Ethan Kross calls those moments chatter. “When the inner voice runs amok and chatter takes the mental microphone,” he writes, “our mind not only torments but paralyzes us.” Luckily, there are tools we can use to take back the mic, and in this episode, Ethan talks Rufus through them.

Humor is no laughing matter. It inspires innovation, strengthens relationships, disarms tension, and makes you look smart. Seriously. So why are we all afraid to be funny at work? In their new book, “Humor, Seriously,” Stanford professors Jennifer Aaker and Naomi Bagdonas say the recipe for professional success and personal fulfillment is to lighten up, pack a little levity in your briefcase, and start living your life on the precipice of a smile. In today’s episode, they dig into the neuroscience of laughter, share tips for crafting office-safe jokes, and help Rufus improve his comic chops.

A few years ago, as he watched his young daughter try out one hobby after another, a thought crossed Tom Vanderbilt’s mind: Why do we work so hard to get our kids to learn new skills when most of us adults stopped trying new things ages ago? For Tom, that contradiction became a call to arms. In defiance of the usual objections — it’s too late! you’re too old! — he took up chess, surfing, singing, juggling, and drawing. His goal wasn’t to gain mastery. He just wanted to prove to himself (and the eventual readers of his wonderful new book) that no matter how old you are or untalented you feel, being a beginner is a great way to stimulate your brain, meet new people, and bring a little adventure into your life.

We’re taught that the mark of surefire intelligence is the ability to think and learn. But in his new book, “Think Again,” Adam Grant says that in our turbulent world, there’s a more important skill: the ability to rethink and unlearn. If you can learn how to revise your opinions, check your ego, and admit when you’re wrong, then you’ll be on a path toward wisdom and joy.

Sure, opposable thumbs are handy. But in his brilliant new book, “This Is the Voice,” John Colapinto says the voice is our species’ greatest attribute. We rely on it to communicate and collaborate, woo our mates and protect our children, make art and win wars. John would know. A rock ‘n’ roll vocal injury changed his relationship with his instrument and set him on a path to better understand what his voice means to him — and what the voice means to humanity.

If you managed to stay awake during Bio 101, then you probably think you have a basic understanding of how your brain works. Not so, says neuroscientist Lisa Feldman Barrett. In this cerebral yet highly entertaining conversation with Next Big Idea Club curator Daniel Pink, Lisa says our brains are made for budgeting, not thinking. She debunks the myth of the lizard brain. And she makes the far-out claim that everything you see and hear, including this podcast, is a hallucination.

In all likelihood, some of the biggest moments in your life, like meeting your spouse or finding your job, were the result of a chance encounter or fortunate coincidence. You got lucky. But Christian Busch, who directs the global economy program at NYU, says that with the right mindset, you can regard luck not as something that happens to you but as a skill you can cultivate. In this lively conversation, he gives Rufus pointers on how to live serendipitously, describes the surprising power of near-death experiences, and argues that spilling coffee on people may not be such a bad thing.

Every day, Dr. Carl Hart goes into his laboratory at Columbia University and gets people high. That research has led him to a surprising conclusion: the predominant effects of the drugs he administers — substances like cannabis, cocaine, heroin, and meth — are positive. In this unflinching conversation about Dr. Hart’s bold new book, “Drug Use for Grown-Ups,” Carl and Rufus discuss their own experiences with drugs, connect drug criminalization to structural racism, and ask whether drug use by responsible adults can be a good thing.