Health & Veritas

Harlan reports on a new study suggesting dramatic health benefits from bursts of vigorous activity; Howie explains how genetic science is starting to illuminate a mystery in his own medical history. And they are joined by Yale physician and scientist Jeffrey Gruen to discuss his work identifying the genetic variants associated with dyslexia and designing early interventions for kids with learning disabilities. Links: "Association of wearable device-measured vigorous intermittent lifestyle physical activity with mortality" Dr. Jeffrey Gruen –The New Yale Program for Learning Disabilities Research New Haven Lexinome Project Sherman Weissman, MD "Revenge of the gaslit patients: Now, as scientists, they're tackling Ehlers-Danlos syndromes" Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Harlan reports on new research on effective prostate cancer screening; Howie explores the potential of the AI language model ChatGPT. And they're joined by Dr. Kristen Nwanyanwu, a Yale ophthalmologist with a focus on closing the racial gap in the treatment of diabetic retinopathy. Links: "Prostate Cancer Screening with PSA and MRI Followed by Targeted Biopsy Only" Kristen Nwanyanwu: "Addressing Disparities in Ophthalmic Research" "U.S. Supreme Court rules on University of Michigan cases" "The Pandemic's Legacy Is Already Clear" Kristen Nwanyanwu: "Ophthalmology Departments Remain Among the Least Diverse Clinical Departments at United States Medical Schools" Minority Ophthalmology Mentoring Eyeful LLC ChatGPT: Optimizing Language Models for Dialogue Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Howie and Harlan are joined by Dr. Eric Topol, a physician and writer who is widely recognized both as a leading researcher and a public voice on medicine and health. They discuss his career turn toward genomics and digital health, and the fight against misinformation on Twitter. Links: "Adding Salt to Foods and Risk of Cardiovascular Disease" Eric Topol: Ground Truths Eric Topol: The Creative Destruction of Medicine: How the Digital Revolution Will Create Better Health Care (2011) Eric Topol: The Patient Will See You Now: The Future of Medicine Is in Your Hands (2015) Eric Topol: Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again (2019) Eric Topol on Twitter Scott Gottlieb on LinkedIn: "The GLP-1s emerge as the largest class of peptide drugs of all time" Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Harlan reports on a unprecedented recall of ventilators and CPAP machines; Howie discusses a new approach to tackling the issue of antimicrobial resistance. And they're joined by Dr. Nancy Brown, dean of the Yale School of Medicine, to discuss her career path and her investments in developing talent. Links: FDA Update: Certain Philips Respironics Ventilators, BiPAP Machines, and CPAP Machines Recalled Due to Potential Health Risks "Getting to know Yale leaders—Nancy Brown" WHO fact sheet: antimicrobial resistance PASTEUR Act of 2021 "The PASTEUR Act can help win the war against superbugs" Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Harlan provides updates on R.S.V., flu, and COVID-19; Howie considers the growing use of hallucinogens for treatment of severe depression. And they are joined by Dr. Vineet Arora, dean of medical education at the University of Chicago, to discuss the future of medical Twitter and how medical education is changing in the wake of the pandemic. Links: "A 'Tripledemic'? Flu, R.S.V. and Covid May Collide This Winter, Experts Say" "Twitter has spent years trying to combat health misinformation. Will Musk's takeover make that harder?" "A fake tweet sparked panic at Eli Lilly and may have cost Twitter millions" "The 'bot holiday' and why clinicians can't tackle disinformation alone" "What is #MedMastodon & why might we need it?" "Some Twitter users flying the coop hope Mastodon will be a safe landing" University of Chicago: Pritzker EVOLVES "Colorado Legalizes Magic Mushrooms" "Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression" Learn more about the MBA for Executives program at Yale SOM Email Howie and Harlan comments or questions.

Dr. Marcella Nunez-Smith, a Yale internist and health equity advocate who led initiatives in the Biden administration, shares her insights on combating systemic health disparities. She discusses the crucial role of economic opportunities in achieving health equity. Marcella emphasizes community workforce development as vital for enhancing access to care. Additionally, she addresses the success in closing racial vaccination gaps during the pandemic and highlights the importance of accountability and data in driving local health initiatives. Her optimism for future health equity leaders is palpable.

Harlan describes a revealing new study on the long-term impacts of COVID; Howie reflects on the escalating costs of health insurance. And they are joined by Dr. Lisa Leffert, Yale's chief of anesthesiology, to discuss her unusual career path, disparities in maternal mortality, and her approach to tackling the gender pay gap in the field. Links: "Cardiovascular disease and mortality sequelae of COVID-19 in the UK Biobank" Health & Veritas: Saving Mothers' Lives (Ep. 7) Lisa Leffert: "The 'Unexplained' Portion of the Gender Pay Gap in Anesthesiology" KFF: 2022 Employer Health Benefits Survey Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Howie and Harlan are joined by physician, sociologist, and thinker Nicholas Christakis to talk about how humans have evolved to form powerful connections. Howie provides updates on concussions among high school athletes and the use of Ivermectin for COVID, and Harlan remembers Dr. Barry Zaret, an important figure in cardiology at Yale and beyond. Links: In Memoriam: Barry L. Zaret, MD Yale News: "Blueprint: The Evolutionary Origins of a Good Society" Steven Pinker: "The Better Angels of our Nature" "The Moral Life of Babies" Nicholas Christakis: "The Spread of Obesity in a Large Social Network over 32 Years" Nicholas Christakis: "Algorithms for seeding social networks can enhance the adoption of a public health intervention in urban India" "Concussions are a bigger problem for kids' football than the NFL" "Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19" "These Doctors Admit They Don't Want Patients With Disabilities" Learn more about the MBA for Executives program at Yale SOM Email Howie and Harlan comments or questions.

Harlan reports on a new study testing the effectiveness of the OCD drug fluvoxamine in treating COVID; Howie reflects on the potential of continuous glucose monitoring for people with diabetes. And they're joined by Dr. Utibe Essien of the University of Pittsburgh to discuss the barriers preventing people of color from getting innovative new treatments and medications. Links: "Fluvoxamine for Outpatient Treatment of COVID-19: A Decentralized, Placebo-controlled, Randomized, Platform Clinical Trial" Utibe Essien: "Association of Neighborhood Disadvantage and Anticoagulation for Patients with Atrial Fibrillation in the Veterans Health Administration: the REACH-AF Study" "Prevalence and Correlates of Patient Rationing of Insulin in the United States: A National Survey" Harlan Krumholz: "Life Expectancy after Myocardial Infarction by Hospital Performance" "Racial bias in pain assessment and treatment recommendations, and false beliefs about biological differences between blacks and whites" Antiracism in Medicine podcast "Intermittently Scanned Continuous Glucose Monitoring for Type 1 Diabetes" Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Howie and Harlan check in on new research and health issues in the news, including studies on colonoscopies and the timing of hypertension medication, the state of the monkey pox and polio outbreaks, and the wave of legislation restricting treatment of trans youth. Links: "Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death" "Monkeypox Cases Are Declining in New York City and Globally" "WHO declares monkeypox a global health emergency as infections soar" "Evening dosing of blood pressure medication not better than morning dosing" "Arkansas cannot enforce ban on gender-affirming care for trans kids, court rules" "Watch Jon Stewart Calmly Excoriate the Arkansas Attorney General on Anti-Trans Legislation" "Yale's Emily Wang and two alumni win MacArthur 'genius' awards" Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.