Health & Veritas

Howie and Harlan are joined by Josh Geballe, a Yale SOM graduate who serves as managing director of Yale Ventures, Yale's initiative overseeing the translation of research into impactful new companies. Harlan reports from the debate on AI in medicine; Howie reflects on the FDA's approval process for an over-the-counter birth control pill. Links: "Iwasaki to Receive Else Kröner Fresenius Prize Supporting Research Into Long COVID and Similar Conditions" "As Covid Emergency Ends, U.S. Response Shifts to Peacetime Mode" "ChatGPT - Reshaping medical education and clinical management" "Performance of ChatGPT on USMLE: Potential for AI-assisted medical education using large language models" "Artificial Hallucinations in ChatGPT: Implications in Scientific Writing" Yale Ventures Tsai Center for Innovative Thinking at Yale "The economic transformation: What would change in the net-zero transition" "Joint Meeting of the Nonprescription Drugs Advisory Committee and the Obstetrics, Reproductive, and Urologic Drugs Advisory Committee May 9, 2023 – May 10, 2023" FDA | May 9-10, 2023: Joint Meeting of the Nonprescription Drugs Advisory Committee and the Obstetrics, Reproductive and Urologic Drugs Advisory Committee Meeting Announcement "F.D.A. Advisers Weigh Allowing First U.S. Over-the-Counter Birth Control Pill" Food and Drug Administration | Prescription-to-Nonprescription (Rx-to-OTC) Switches "Over-the-counter sales of statins and other drugs for asymptomatic conditions" Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Howie and Harlan are joined by Amanda Skinner, a Yale SOM graduate who leads Planned Parenthood of Southern New England. Harlan reflects on the potential and the dangers of artificial intelligence; Howie reports on an advisory from Surgeon General Vivek Murthy about the public health impact of loneliness and social isolation. Links: "Five Alumni Named 2021-22 Donaldson Fellows" "Idaho hospital to stop delivering babies as doctors flee over abortion ban" "Abortion providers in the United States: expanding beyond obstetrics and gynecology" "'The Godfather of A.I.' Leaves Google and Warns of Danger Ahead" "Is artificial intelligence advancing too quickly? What AI leaders at Google say" "ChatGPT may have better bedside manner than some doctors, but it lacks some expertise" "Surgeon General: We Have Become a Lonely Nation. It's Time to Fix That." "Our Epidemic of Loneliness and Isolation" "Good genes are nice, but joy is better" Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Howie and Harlan are joined by Elizabeth Arleo, a radiologist with a focus on breast imaging and the author of First, Eat Your Frog: And Other Pearls for Professional Working Mothers. Harlan reports on the state of AI in healthcare; Howie reflects on the epidemic of lung injuries from vaping. Links: "Epic, Microsoft bring GPT-4 to EHRs" Harlan Krumholz: "Foundation models for generalist medical artificial intelligence" "Is artificial intelligence advancing too quickly? What AI leaders at Google say" Elizabeth Arleo: First, Eat Your Frog: And Other Pearls for Professional Working Mothers Howard Forman: "Why don't female medical students choose diagnostic radiology? A review of the current literature" American Cancer Society: American Cancer Society Recommendations for the Early Detection of Breast Cancer CDC: Outbreak of Lung Injury Associated with the Use of E-Cigarette, or Vaping, Products "Juul Reaches $462 Million Settlement With New York, California and Other States" Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Howie and Harlan are joined by Megan Ranney, who will become the dean of the newly independent Yale School of Public Health later this year. Harlan reflects on the research that is helping us understand aging at a cellular level; Howie discusses a new study that he co-authored which examines the costs that make it harder for many mothers to breastfeed. Links: "Accelerated Epigenetic Aging Is Associated with Multiple Cardiometabolic, Hematologic, and Renal Abnormalities: A Project Baseline Health Substudy" Outlive by Peter Attia with Bill Gifford "Megan Ranney named dean of Yale School of Public Health" "Yale School of Public Health to become self-supporting, independent school" Megan Ranney: "To prevent gun injury, build better research" Megan Ranney: "We need more research on guns. Here are 5 questions we can answer." Howard Forman: "No such thing as a free lunch: The direct marginal costs of breastfeeding" Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Howie and Harlan are joined by Cary Gross, professor of medicine and public health and director of the National Clinician Scholars Program at Yale, to discuss his creative approach to research and his sometimes contrarian stances on cancer screening and not holding medical conferences in states that ban abortion. Harlan explains the nuances of new research about mortality risks tied to weight loss in older adults; Howie discusses his concerns over courts interfering with FDA drug approval processes arising from two cases tied to the medical abortion pill mifepristone. Links: "The Relation between Funding by the National Institutes of Health and the Burden of Disease" "Allocation of National Institutes of Health Funding by Disease Category in 2008 and 2019" "Too Many Older Patients Get Cancer Screenings" National Cancer Institute | National Cancer Act of 1971 "Holding Medical Professional Society Scientific Meetings Only in States That Protect Abortion Rights—Clinical and Ethical Considerations" "Associations of Change in Body Size With All-Cause and Cause-Specific Mortality Among Healthy Older Adults" "Judge Invalidates F.D.A. Approval of the Abortion Pill Mifepristone" "Democratic state attorneys general sue Biden administration over abortion pill rules" Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Howie and Harlan are joined by Michael Alosco, co-director of Boston University's Chronic Traumatic Encephalopathy Center, to discuss the consequences of years of hits to the head for football players and other athletes. Harlan reports on research that clarifies how to treat high cholesterol; Howie discusses a judge's ruling striking down coverage of preventative care. Links: "Treat-to-Target or High-Intensity Statin in Patients With Coronary Artery Disease" Boston University CTE Center UNITE Brain Bank | BU CTE Center Michael Alosco: "Repetitive Head Impacts and Chronic Traumatic Encephalopathy" Michael Alosco: "White matter hyperintensities in former American football players" Michael Alosco: "Age of first exposure to tackle football and chronic traumatic encephalopathy" "Explaining Litigation Challenging the ACA's Preventive Services Requirements: Braidwood Management Inc. v. Becerra" "Federal Judge Strikes Down Obamacare Requirement for Free Preventive Care" Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Howie and Harlan are joined by Helen Burstin to discuss her career examining issues of equity and quality in healthcare, and her current role as CEO of the Council of Medical Specialty Societies. Harlan reports on new research about the daily health effects of coffee; Howie looks at two investigations of misconduct by the insurance company Cigna. Links: "Acute Effects of Coffee Consumption on Health among Ambulatory Adults" Helen Burstin: "Socioeconomic Status and Risk for Substandard Medical Care" Helen Burstin: "Impact of language barriers on patient satisfaction in an emergency department" National Quality Forum "Your Surgeon Is Probably a Republican, Your Psychiatrist Probably a Democrat" Council of Medical Specialty Societies: CMSS Statement on Supreme Court Decision in Dobbs v. Jackson Women's Health Case Council of Medical Specialty Societies: The Promise of Patient-Led Research Integration into Clinical Registries and Research Council of Medical Specialty Societies: Patient-Led Research Scorecards Patient-Led Research Collaborative: About Us Medicare.gov: How do Medicare Advantage Plans work? "How Cigna Saves Millions by Having Its Doctors Reject Claims Without Reading Them" "DOJ sues Cigna over alleged Medicare Advantage overpayments" Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Howie and Harlan are joined by Michael Ivy, a surgeon and Yale New Haven Health's deputy chief medical officer, to discuss the mental health issues facing physicians and his own experience with burnout and depression. Harlan reports on new research casting doubt on the benefits of intermittent fasting; Howie explains how a new drug can help reduce the disproportionate rate of renal failure among people of African descent. If you or someone you know is struggling with mental health, you can call 988 or text HOME to 741741 for 24/7 support. Links: "Are you napping too much?" "Effects of Time-Restricted Eating on Nonalcoholic Fatty Liver Disease" U.S. Department of Health and Human Services: Health Worker Burnout Stanford Medicine: The Stanford Model of Professional Fulfillment College of American Pathologists College: CURES Act Fact Sheet "Inaxaplin for Proteinuric Kidney Disease in Persons with Two APOL1 Variants" "Inhibiting APOL1 to Treat Kidney Disease" Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Howie interviews Harlan about his path to medicine and his career as a physician and scientist. Links: Harlan Krumholz: "Community-acquired bacteremia in patients with acquired immunodeficiency syndrome: clinical presentation, bacteriology, and outcome" Harlan Krumholz: "Cost effectiveness of thrombolytic therapy with streptokinase in elderly patients with suspected acute myocardial infarction" Harlan Krumholz: "Participation in Cancer Clinical Trials" Harlan Krumholz: "Strategies for reducing the door-to-balloon time in acute myocardial infarction" Harlan Krumholz: "Hospital-Readmission Risk - Isolating Hospital Effects from Patient Effects" Harlan Krumholz: "An administrative claims measure suitable for profiling hospital performance on the basis of 30-day all-cause readmission rates among patients with heart failure" Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Howie and Harlan are joined by Ami Parekh, chief health officer of Included Health, which provides virtual care and data-driven guidance on finding the right doctor. Harlan reviews new research on alternatives to statins; Howie looks at the effect of mandated sick leave for screening tests like mammographs and colonoscopies. Links: "Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients" "Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment" "Prevalence of statin intolerance: a meta-analysis" "Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials" Included Health "Grand Rounds Health and Doctor On Demand Acquires Included Health" "Cancer Screening after the Adoption of Paid-Sick-Leave Mandates" Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.