
DTx Podcast with Eugene Borukhovich
Host Eugene Borukhovich explores how non-molecular therapies and interventions can prevent, manage or even cure diseases. Learn about the rapidly evolving field of Digital Therapeutics, its history, the evolving regulatory and reimbursement frameworks, and the trailblazers creating and advancing this industry.
Latest episodes

Apr 11, 2023 • 26min
Ep59: The DTx Addressing the Mental Health of Cancer Patients
In this episode, we hear from Andrzej Jończyk, MD, Co-founder and CEO USA of Prosoma. In their own words, Prosoma develops a portfolio of digital therapeutic medical software products that cover the entirety of behavioral treatment needs of cancer patients.In this episode, we cover:
The background to Prosoma
The funding journey and milestones reached
Patient experience using Prosomo's Living Well product
How Living Well is personalized specifically for women living with cancer
Evidence generation and journey to PDT & DiGA
Engagement levels in the technology
Commercial traction across Europe and expansion into the USA
Guest Links and Resources:
Connect with Andrzej Jończyk, MD on LinkedIn
Visit Prosoma.com
Host Links:
Connect with Eugene Borukhovich: Twitter | LinkedIn
Connect with Chandana Fitzgerald, MD: Twitter | LinkedIn
Connect with YourCoach.health: Website | Twitter
Check out Shot of Digital Health with Eugene and Jim Joyce: Website | Podcast App
HealthXL: Website | Twitter | Join an Event
Digital Therapeutics Podcast would not be possible without the support of leading DTx organizations. Thank you to:> Presenting Partner: Amalgam Rx> Contributing Partners and Sponsors: Akili | Bayer G4A | Lindus HealthFollow Digital Health Today:Browse Episodes | Twitter | LinkedIn | Facebook | InstagramFollow Health Podcast Network:Browse Shows | LinkedIn | Twitter | Facebook | Instagram

Apr 4, 2023 • 26min
Ep58: The Biofeedback Video Game Teaching Kids Coping Skills
In this episode, we hear from Jason Kahn, Co-founder and Chief Science Officer at Mightier. Mightier, in their own words, is a digital program for kids that uses their heart rate to teach coping skills through game-based play.In this episode, we cover:
The founding story and meaning behind the name 'Mightier'
Funding journey and key milestones in bringing the product to market
Child and parent experience using Mightier
The total addressable market for DTx in pediatric behavioral health
The mechanism of action and the underlying technology utilized in Mightier
Working with gaming companies
Evidence generation and RCTS
PDT's vs DTC's
Guest Links and Resources:
Connect with Jason Kahn on LinkedIn
Visit Mightier
Host Links:
Connect with Eugene Borukhovich: Twitter | LinkedIn
Connect with Chandana Fitzgerald, MD: Twitter | LinkedIn
Connect with YourCoach.health: Website | Twitter
Check out Shot of Digital Health with Eugene and Jim Joyce: Website | Podcast App
HealthXL: Website | Twitter | Join an Event
Digital Therapeutics Podcast would not be possible without the support of leading DTx organizations. Thank you to:> Presenting Partner: Amalgam Rx> Contributing Partners and Sponsors: Akili | Bayer G4A | Lindus HealthFollow Digital Health Today:Browse Episodes | Twitter | LinkedIn | Facebook | InstagramFollow Health Podcast Network:Browse Shows | LinkedIn | Twitter | Facebook | Instagram

Mar 28, 2023 • 39min
Ep57: The App Treating IBS
In this episode we hear from Simon Levy, CEO and Co-founder, and Ann Montgomery, Chief Product Officer at Mahana. In their own words, Mahana develops digital treatments for people living with chronic health conditions, and their first treatment, Mahana for IBS, is now available as an FDA-cleared app.In this episode, we cover:
The founding story and funding journey of Mahana
Complexities of the end to end patient experience
The freemium model and how that translates into a PDT
Evidence generation and FDA clearance process
Scaling plans for PDTs
Guest Links and Resources:
Connect with Simon Levy on LinkedIn
Connect with Ann Montgomery on LinkedIn
Visit Mahana.com
Host Links:
Connect with Eugene Borukhovich: Twitter | LinkedIn
Connect with Chandana Fitzgerald, MD: Twitter | LinkedIn
Connect with YourCoach.health: Website | Twitter
Check out Shot of Digital Health with Eugene and Jim Joyce: Website | Podcast App
HealthXL: Website | Twitter | Join an Event
Digital Therapeutics Podcast would not be possible without the support of leading DTx organizations. Thank you to:> Presenting Partner: Amalgam Rx> Contributing Partners and Sponsors: Akili | Big Health | Click Therapeutics | Lindus Health | Orion PharmaFollow Digital Health Today:Browse Episodes | Twitter | LinkedIn | Facebook | InstagramFollow Health Podcast Network:Browse Shows | LinkedIn | Twitter | Facebook | Instagram

Mar 23, 2023 • 28min
Special Episode: Industry Leaders Weigh in on the Recent Pear Therapeutics News and the Future of Prescription Digital Therapeutics
In this special episode of DTx Podcast, Eugene is joined by Brent Vaughan, CEO of Cognito, as well as industry leaders from previous episodes, to weigh in on the recent Pear Therapeutics news and the future of prescription digital therapeutics.In this episode, we cover:
The impact on the PDT market
Future efforts to move DME to PDT
The impact on the entrepreneurs currently developing PDT’s
Predictions on the future of Pear Therapeutics
Reflections on the history and future of DTx from Chris Bergstrom (Amalgam RX), David Klein (Click Therapeutics), Andy Molnar (DTA), Sammeli Liikkanen (Orion), Francesca Wuttke (nen), Andrzej Jonczyk (Prosoma), Steve Driver (Advocate Health) and Grady Hannah (NightWare)
Join the HealthXL platform for free today and be the first to read their analysis of Pear’s predicament and what it means for the DTx industry: https://portal-beta.healthxl.com/?s=2fb5Guest Links and Resources:
Connect with Brent Vaughan on LinkedIn
Connect with Chris Bergstrom on LinkedIn
Connect with David Klein on LinkedIn
Connect with Andy Molnar on LinkedIn
Connect with Sammeli Liikkanen on LinkedIn
Connect with Francesca Wuttke on LinkedIn
Connect with Andrzej Jonczyk on LinkedIn
Connect with Steve Driver on LinkedIn
Connect with Grady Hannah on LinkedIn
Host Links:
Connect with Eugene Borukhovich: Twitter | LinkedIn
Connect with Chandana Fitzgerald, MD: Twitter | LinkedIn
Connect with YourCoach.health: Website | Twitter
Check out Shot of Digital Health with Eugene and Jim Joyce: Website | Podcast App
HealthXL: Website | Twitter | Join an Event
Digital Therapeutics Podcast would not be possible without the support of leading DTx organizations. Thank you to:> Presenting Partner: Amalgam Rx> Contributing Partners and Sponsors: Akili | Big Health | Click Therapeutics | Lindus Health | Orion PharmaFollow Digital Health Today:Browse Episodes | Twitter | LinkedIn | Facebook | InstagramFollow Health Podcast Network:Browse Shows | LinkedIn | Twitter | Facebook | Instagram

Mar 21, 2023 • 41min
Ep56: Virtual Reality for Chronic Pain Management
In this episode, we hear from Josh Sackman, President and Co-founder of AppliedVR. AppliedVR, in their own words, provide virtual reality-based treatments that represent a comprehensive approach to chronic pain that empowers patients with accessible digital tools self-managed in their own home.In this episode, we cover:
The origin story of AppliedVR
Transitioning from an app store for health VR to focus pain management market
Patient experience and the pain management pipeline
Funding journey and key funding milestones
The scientific hypothesis of "mind over matter" behind AppliedVR's approach and evidence generation journey
The FDA approval process for AppliedVR and lessons learned for entrepreneurs.
AppliedVR's current business hypothesis and scaling plan
Market channels and scaling VR
Guest Links and Resources:
Connect with Josh Sackman on LinkedIn
Visit www.appliedvr.io
Host Links:
Connect with Eugene Borukhovich: Twitter | LinkedIn
Connect with Chandana Fitzgerald, MD: Twitter | LinkedIn
Connect with YourCoach.health: Website | Twitter
Check out Shot of Digital Health with Eugene and Jim Joyce: Website | Podcast App
HealthXL: Website | Twitter | Join an Event
Digital Therapeutics Podcast would not be possible without the support of leading DTx organizations. Thank you to:> Presenting Partner: Amalgam Rx> Contributing Partners and Sponsors: Akili | Big Health | Click Therapeutics | Lindus Health | Orion PharmaFollow Digital Health Today:Browse Episodes | Twitter | LinkedIn | Facebook | InstagramFollow Health Podcast Network:Browse Shows | LinkedIn | Twitter | Facebook | Instagram

Mar 14, 2023 • 30min
Ep55: Enabling Behavior Change Through Acceptance, Awareness and Mindfulness
In this episode, we hear from Jo Masterson, CEO and Co-Founder of 2Morrow. In their own words 2Morrow's mission is to help millions improve their lives with the use of evidence-based, behavioral change programs.In this episode, we cover:
The founding philosophy of 2Morrow and co-founding a company with your partner
The funding journey
The NIH grant for 2Morrow's program for pain
Using a DTx to cope with pain that will not be effected by behaviour change
Consumer experience using different 2Morrow programs
Core principles of acceptance, awareness and mindfulness
Evidence generation and approach to market
Guest Links and Resources:
Connect with Jo Masterson on LinkedIn
Visit www.2morrowinc.com
Host Links:
Connect with Eugene Borukhovich: Twitter | LinkedIn
Connect with Chandana Fitzgerald, MD: Twitter | LinkedIn
Connect with YourCoach.health: Website | Twitter
Check out Shot of Digital Health with Eugene and Jim Joyce: Website | Podcast App
HealthXL: Website | Twitter | Join an Event
Digital Therapeutics Podcast would not be possible without the support of leading DTx organizations. Thank you to:> Presenting Partner: Amalgam Rx> Contributing Partners and Sponsors: Akili | Big Health | Click Therapeutics | Lindus Health | Orion PharmaFollow Digital Health Today:Browse Episodes | Twitter | LinkedIn | Facebook | InstagramFollow Health Podcast Network:Browse Shows | LinkedIn | Twitter | Facebook | Instagram

Mar 7, 2023 • 26min
Ep54: The Video Game Tackling the Youth Mental Health Crisis
In this episode, we hear from Brian Wallace, CMO and Co-Founder of Calmsie. Calmsie in their own words are empowering children to develop emotional resilience from an early age. Calmsie creates engaging DTx video games designed to improve outcomes for children with depression and anxiety.In this episode, we cover:
Translating addiction science to treat depression and anxiety in children
The origin story and funding journey to Calmsie
Parent and child experiences using the gamified program
Emotional resilience training for prevention of mental health issues
How the Calmsie video game affects the brain
Evidence generation and deciding on PDT vs non-PDT routes
The free workbook helping children understand the war in Ukraine
Guest Links and Resources:
Connect with Brian Wallace on LinkedIn
Visit calmsie.ai
Episode PDF
Host Links:
Connect with Eugene Borukhovich: Twitter | LinkedIn
Connect with Chandana Fitzgerald, MD: Twitter | LinkedIn
Connect with YourCoach.health: Website | Twitter
Check out Shot of Digital Health with Eugene and Jim Joyce: Website | Podcast App
HealthXL: Website | Twitter | Join an Event
Digital Therapeutics Podcast would not be possible without the support of leading DTx organizations. Thank you to:> Presenting Partner: Amalgam Rx> Contributing Partners and Sponsors: Akili | Big Health | Click Therapeutics | Lindus Health | Orion PharmaFollow Digital Health Today:Browse Episodes | Twitter | LinkedIn | Facebook | InstagramFollow Health Podcast Network:Browse Shows | LinkedIn | Twitter | Facebook | Instagram

Feb 28, 2023 • 34min
Ep53: The App Preventing Cognitive Decline
In this episode, we hear from Sylvain Piquet, COO and Co-founder of Five Lives, the app that leverages the new science of brain aging, neuroplasticity, and cognitive reserve to help people improve their brain health and prevent cognitive decline and dementia.In this episode, we cover:
The origin story of Five Lives and the motivation behind focusing on dementia and cognitive decline.
The demographics benefitting from using Five Lives
Gamifying behaviour change
Evidence generation and funding journey
The advantages of direct-to-consumer distribution through the app store
How digital therapeutics can fit within the NHS
The challenges of implementing DTx across UK, French, and German markets
Guest Links and Resources:
Connect with Sylvain Piquet on LinkedIn
Visit www.fivelives.health
Host Links:
Connect with Eugene Borukhovich: Twitter | LinkedIn
Connect with Chandana Fitzgerald, MD: Twitter | LinkedIn
Connect with YourCoach.health: Website | Twitter
Check out Shot of Digital Health with Eugene and Jim Joyce: Website | Podcast App
HealthXL: Website | Twitter | Join an Event
Digital Therapeutics Podcast would not be possible without the support of leading DTx organizations. Thank you to:> Presenting Partner: Amalgam Rx> Contributing Partners and Sponsors: Akili | Big Health | Click Therapeutics | Lindus Health | Orion PharmaFollow Digital Health Today:Browse Episodes | Twitter | LinkedIn | Facebook | InstagramFollow Health Podcast Network:Browse Shows | LinkedIn | Twitter | Facebook | Instagram

Feb 21, 2023 • 31min
Ep52: Mental Health Care Without The Wait List
In this episode, we hear from Hannes Klöpper, CEO of HelloBetter. HelloBetter, in their own words, wants to empower as many people as possible to manage their own mental health and improve their quality of life – anywhere and at any time, without the wait lists.In this episode, we cover:
The origin story of HelloBetter, from university research to becoming a digital therapeutic.
Structuring a DTx into accessible and consumable courses
The patient journey, from receiving a prescription to activating and using the platform.
The DiGA process: evidence, benefits and commercialization
The reaction of EU vs US investors
Guest Links and Resources:
Connect with Hannes Klöpper on LinkedIn
Visit hellobetter.de
Host Links:
Connect with Eugene Borukhovich: Twitter | LinkedIn
Connect with Chandana Fitzgerald, MD: Twitter | LinkedIn
Connect with YourCoach.health: Website | Twitter
Check out Shot of Digital Health with Eugene and Jim Joyce: Website | Podcast App
HealthXL: Website | Twitter | Join an Event
Digital Therapeutics Podcast would not be possible without the support of leading DTx organizations. Thank you to:> Presenting Partner: Amalgam Rx> Contributing Partners and Sponsors: Akili | Big Health | Click Therapeutics | Lindus Health | Orion PharmaFollow Digital Health Today:Browse Episodes | Twitter | LinkedIn | Facebook | InstagramFollow Health Podcast Network:Browse Shows | LinkedIn | Twitter | Facebook | Instagram

Feb 14, 2023 • 36min
Ep51: Don't Panic, There's a DTx for That
In this episode, we hear from Joe Perekupka, CEO of Freespira. In their own words Freespira is 'the only medication-free, FDA-cleared digital therapeutic treatment proven to significantly reduce or eliminate symptoms of panic disorder, panic attacks and post-traumatic stress disorder in just 28 days.'In this episode, we cover:
The founding story of Freespira
The user experience from prescription to daily use
The role of health coaches within Freespira
Identifying potential candidates for Freespira
The current landscape for panic disorder treatment and research into MDMA-assisted therapies
Evidence generation to FDA approval journey
Evolving pricing models
The scope of PTSD across the US
Guest Links and Resources:
Connect with Joseph Perekupka on LinkedIn
Visit freespira.com
Host Links:
Connect with Eugene Borukhovich: Twitter | LinkedIn
Connect with Chandana Fitzgerald, MD: Twitter | LinkedIn
Connect with YourCoach.health: Website | Twitter
Check out Shot of Digital Health with Eugene and Jim Joyce: Website | Podcast App
HealthXL: Website | Twitter | Join an Event
Digital Therapeutics Podcast would not be possible without the support of leading DTx organizations. Thank you to:> Presenting Partner: Amalgam Rx> Sponsors: Akili | Big Health | Click Therapeutics | Lindus HealthFollow Digital Health Today:Browse Episodes | Twitter | LinkedIn | Facebook | InstagramFollow Health Podcast Network:Browse Shows | LinkedIn | Twitter | Facebook | Instagram