If you've enjoyed any comedy in the last 20 years, there's a good chance Neal Brennan helped make it. He's a veteran comic, writer, director, and co-creator, with Dave Chappelle, of the acclaimed Chappelle's Show. Over the past 20-plus years, he's also tried everything he could think of to tame his depression. Hear Neal's epic journey to feeling pretty good.

She’s one of the most influential and innovative comedians of the last few decades, but before all that, Margaret Cho was a Korean-American girl growing up in the 1970s in San Francisco. We hear about the sometimes very darkly humorous ways her family and culture dealt with depression and suicide, and how she harnessed her own depression to begin her comedy. Along the way, the keys to Margaret’s often-shocking comedic style emerge and lead to making people upset in New Jersey. 

Wil Wheaton was a child star in Stand By Me, a regular on Star Trek: The Next Generation as a teenager, and has been trying to figure out his role in show business for a long time since then. He was dealing with the pressures of fame and the fickle tastes of Hollywood, all while dealing with a chemical imbalance in his brain that made him prone to anxiety and depression. Wil’s better now thanks to medication, but despite his long IMDb page and regular work on The Big Bang Theory, his hit YouTube show, and a thriving and varied career, he sees himself primarily as a failed actor.

Season 2 of The Hilarious World of Depression starts on September 25, 2017. Get a jump on it by hearing from some of the comics, actors, authors, and musicians you'll get to know this season.

What if clinical depression was not just a thing in someone’s brain but an actual other person entirely? What would they look like? Act like? Who would they be? And how would you interact with such a person? It’s a mental exercise that many find helpful in isolating the disease from the self to better manage it. We asked our listeners to describe their depression. Most chose humans, one chose a very confused monster.

If you are having problems with your mental health, please get help. You’ve heard that before on this show and probably plenty of other places as well. But how do you actually do that? How do you go about finding professional help to get things on a better track? It’s a process that can be complicated and overwhelming, which means loads of people don’t get the help they need. On this episode, we talk with Dr. Ken Duckworth, Medical Director of the National Alliance on Mental Illness, about the simplest, best path to getting the help you need. Spoiler: it takes some work, but you can do it.

Depression can be really hard to define, making it difficult for anyone who doesn’t have it to be understand it. And that can make the people who do have it feel that much more alone. We asked our listeners what movie, TV show, artwork, or other piece of culture gets depression right. The answers range from John Cusack yelling out a window to Norwegian expressionist painting, to a cuss-filled bit of sour optimism in the Wild West.

When we asked listeners about their favorite songs to listen to while battling depression, The Mountain Goats’ music kept coming up. We caught up with the band’s founder, singer, and songwriter, John Darnielle, to learn about what goes into his process. We also find out about the music he listens to and the other ways he copes with the depression that has dogged him for many years. Special bonus: a brand new John Darnielle poem.

There are many ways to address depression: therapy, meds, exercise, music. And then there are our own thoughts. We learn the mantras, reminders, and rituals that some of our listeners use to get through it when Clinny D flares up.

When clinical depression, the ol' Clinny D, starts getting the best of our listeners, a lot of them reach for the headphones to fire up some choice tunes. We take another spin through the therapeutic playlist and hear from The Beach Boys, the Grateful Dead, and a Taylor Swift cover you simply must listen to.