How Can Ultrasound destroy cancer cells and even increase immune response elsewhere? Are there any implications for a resonant field based understanding of matter? In this episode we have the fascinating invention of Histotripsy (https://histotripsy.umich.edu/), the non-invasive destruction of cancer cells using ultrasound to look into. Alongside the other headline news that bioengineers are also using acoustics to pattern replacement heart tissue, makes the field of bioacoustics one of the most exciting for the future of medicine.  It is of course the implications of this for the resonant vibrational nature of matter that make this of interest to us on the show, as we attempt to get closer to a true understanding of the nature of reality through our shows on the implications of Einstein’s ‘matter is energy’ findings and quantum mechanics. We get into this after 45 mins or so. We are lucky enough to be speaking today with one of the inventors of Histotripsy technology, Zhen Xu, Associate Professor and Graduate Chair of the Department of Biomedical Engineering at Michigan University. She’s won many awards for her research, including from the American Heart Association and from the National Institute of Health.  00:00 Intro 07:25 Destroying Cancer Cells with Ultrasound  08:50 Issues with tissue heating and toxicity in other non-surgical techniques 09:50 Cavitation: the creation, expansion and collapse of bubbles - gas pockets in the tissue 11:40 Ultrasound propagates through the vibration of tissue particles 13:36 Acoustic Scalpel: Cavitation bubbles are highly visible on ultrasound imaging, for high accuracy treatment 14:45 No spread of tissue heating, so no healthy tissue damage 16:00 The discovery happened by mistake 19:45 She developed new devices for a new phenomenon  21:40 Toxicity of the destroyed tumour is removed from the body in a few months 24:30 Immune response to tumerous cells after treatment, possibly from the debris 25:40 Live cancer cells alter signal pathways to confuse the immunes system 28:00 But once dead the the debris can are noticed by the immune system  29:45 Future tumours or relapses in different locations are picked ups by the immune system 33:30 Treating neurological disease, brain blood clots and epilepsy too, across the skull protection 40:30 Patterning and forming new cell structures using sound (Stanford Med research): Structuring vs destructing using sound 44:30 Resonant frequency in various types of matter and biological tissue 45:00 No evidence from the lab for a resonant theory of tissue/organ health 48:50 Nikola Tesla, “If you want to find the secrets of the Universe, think in terms of energy, frequency and vibration” 52:00 The implications of a wider wave-length fields, for the creation and maintaining of matter and biological life’s structure 56:30 Bioelectric component in organ development (TUFTS Study): The formation of life depends on more than DNA 1:01:00 A field based understanding of physical matter, rather than matter generating fields   References: Dr Zhen Xu 'Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound' Paper Dr Zhen Xu - Histotripsy Group Cosmos Magazine Article on Histotripsy Dr Cliff Cho, Dr Zhen Xu - “...Immune responses that enhance cancer immunotherapy” Paper Sean Wu and Utcan Demerci, Stanford Medical School, Engineering Heart tissue using Bioacoustics Havana Syndrome Nikola Tesla quote, “If you want to find the secrets of the Universe, think in terms of energy, frequency and vibration” Micheal Levin, TUFTS university, “changes in bioelectric signals cause tadpoles to grow eyes in back and tail”

What are the benefits and risks of transhumanist technologies, and why are they so taboo? How do we legislate to avoid existential risks, without holding back too much the enormous possible benefits? How do we secure the mental health, rights and equal access of the public as it inevitably rolls out? So today we have the tricky and somewhat taboo topic of how to ethically guide the ever-increasing application of transhumanist technologies. With the recent advances in bio-technology, and some technologies already making their way into our bodies, it seems that the move towards a transhumanist vision of how to improve our standard of living is already well under way. So the question now is how do we educate ourselves the public and legislate tech corporations and governments, to be sure that people’s mental and physical health, access to opportunities, and personal freedoms are not being compromised in the gold-rush.    Fortunately our guest today is a sociologist and bioethicist with over 25 years of debating exactly these kind of questions. He is the executive director of the Institute for Ethics and Emerging Technologies or IEET, and he is the Associate Provost for Institutional research, Assessment and Planning at the University of Massachusetts Boston, James Hughes. He is a Buddhist and techno-optimist, and was executive director of the World Transhumanist Organisation from 2004-2006. He argues for a democratic transhumanism in which human enhancement technologies should only be allowed if available to everyone, with respect for the rights of the individuals to control their own bodies. He’s the writer of many articles and papers and the author of the book,“Citizen Cyborg: Why democratic societies must respond to the redesigned human of the future”. He is currently working on another book about moral enhancement, tentatively titled “Cyborg Buddha: Using neurotechnology to become better people”. Being a techno-optimist and futurist myself, yet extremely cautious of mankind’s reckless and often blind curiosity when developing technology, I felt it was an important time to take a balanced multi-perspectival look into the ethics and policy development of transhumanist technologies. The interview offered me a process of re-evalutation of my own preconceptions and triggers, so I hope it helps you question your own opinions on this complex topic.  What we discuss: 00:00 Intro 08:00 Difficulty accepting our inevitable transhumanist future 14:00 The taboo of transhumanism and debating toxic issues 19:45 It’s not the tech that’s the risk but the way we use it and legislate it: Max Tegmark 33:20 The History of Transhumanism 44:50 Is Eugenics connected to Transhumanism? 51:00 The roadmap towards markets rolling out transhumanist technologies  52:30 The Kurzweilian paradigm: Smaller, smarter and faster  55:45 Backing up memories - replacing and supplementing brain function 57:00 Instantiating brain backups in robot bodies, cloned bodies or computers 58:45 The Metaverse and brain-internet interfaces assessed 01:03:00 Augmented reality will be more popular than virtual reality 01:06:00 Technology interfering with the evolution of brains and culture 01:10:00 Selective scientific publication about the negative mental health outcomes 01:21:00 Neurolink: brain computer internet interfaces assessed 01:27:00 Gene therapy assessed: the risks of yet further inequality of wealth and power 01:43:50 The Singularity explained 01:56:20 Inequality leads to dangerous conflict VS Transnational collaboration leads to peace References: James J Hughes ‘Citizen Cyborg’ Nick Bostrum - ‘A History of Transhumanist thought’ paper The Institute for Ethics and Emerging Technologies IEET

What evidence is there for quantum effects in biological systems? What are the implications for life in general? Today we’ve got the relatively new field of quantum biology to assess. For years the idea of quantum effects in biological cells was dismissed because live cells were ‘too warm and wet’ to host these sensitive quantum phenomena. But new research into quantum coherence in avian navigation, quantum tunnelling in DNA mutations, in enzymes, even in smell - has brought new interest and study to the field of Quantum Biology. One biochemist, saw all this coming and wrote a book about it 20 years ago called, ‘Quantum Evolution’. He is none other that than Professor of Molecular Genetics at Surrey university, JohnJoe McFadden. His mainstream research is in microbial genetics, particularly in developing new systems biology approaches to infectious diseases. He is a keen promoter of public understanding of science and has given many popular science talks on subjects as varied as evolution and GM food. He also writes popular science articles, particularly for the Guardian newspaper. His specialties are broad including: systems biology, microbiology, evolutionary genetics, infectious diseases, tuberculosis, meningitis, and bionanotechnology. He’s written many books but in this episode we’ll be focussing on material from his newer books, ‘Life on the Edge: the coming age of Quantum Biology’ with physicist Jim Al-Khalili, and ‘Life is Simple: How Occam’s Razor Set Science Free and Unlocked the Universe’. What we discuss: 00:00 Intro 04:30 ‘Too Warm and Wet’ Dismissing quantum consciousness in microtubules 08:40 Roger Penrose: Consciousness may be a field 14:28 The macro universe must be quantum in some way 17:30 Nobody understands the cut-off point between classical large and quantum small 20:20 Quantum coherence in Photosynthesis, enzymes, DNA mutations and avian navigation 23:00 Life ‘amplifies’ the dynamics of stuff going on at the quantum level a to classical level 49:30 University of Surrey ‘Quantum Biology’ PHD graduate program 54:30 Science is becoming more and more interdisciplinary 57:00 Biologists sometimes need to go to quantum mechanics to understand their phenomena 01:12:00 The brain is a receiver and a transmitter: Conscious Electromagnetic information theory 01:16:00 William of Occam’s ‘Razor’ explained 01:22:00 Any sufficiently advanced science would look like metaphysics 01:27:00 Simple models aren’t an ontological claim about the world being simple 01:28:30 Bayesian likelihood reasoning makes sharper predictions References: ‘The Emperor’s New Mind’ Roger Penrose Greg Engel, Quantum Coherence in Photosynthesis paper (2011) Judith Klinman, Quantum Tunneling in Enzymes paper (2006) Thorston Ritz, Avian navigation paper (2004) Johnjoe McFadden, Consciousness: Matter or EMF paper  (2022) 

Philosopher and author Bernardo Kastrup discusses the metaphysics implied by Carl Jung's theories, including the collective unconscious, archetypes, synchronicity, individuation, and the mind at large hypothesis. They explore topics such as dissociation, perception, and the influence of Jim Hollis. The speaker reflects on personal experiences of realizing separateness and the illusory sense of control. They delve into teleology, idealism, the collective unconscious, anomalous phenomena, and the importance of self-awareness. The conversation also touches on books, writing, and future interviews on related subjects.

What exactly are time and space? What are the implications of them not being as they seem? What is the relational interpretation of Quantum Mechanics? What are the implications of its leading to no universal laws of nature?   In this Episode we have the non-linearity of space and time to get our heads around. In Episode #28 with physicist Paul Davies we talked about the implications of Einstein’s work in general, and in this episode we delve deeper into the implications of relativity, particularly of time, but also of space and extension. A subject that our guest has worked on extensively.   Carlo Rovelli is a theoretical physicist who works mainly in quantum gravity research, heading up the Quantum Gravity Group at the Centre de physique Theorique in Aix-Marseille in France. He is also passionate about the philosophy and history of science, so a perfect guest for this show.  Rovelli has written many popular science books, including the bestseller ‘The order of Time’ which we’ll be focussing on today. We’re also going to discuss today the release the his new book ‘Helgoland’, which champions his favourite Relational Interpretation of Quantum Mechanics. Being such a philosophical scientist I’m also going to ask him about Intuition, Buddhist philosophy and psychedelics.    What we discuss:  00:00 Intro  08:05 Time is local not universal  12:32 ‘Block time’ is a bad analogy  13:20 The apparent ‘flow’ of time from the past to the future  18:00 Entropy’s relationship to time  21:15 Is time an illusion?  26:00 Matter and its extension is also relative  27:00 Space is curved  28:00 Back holes are full of space  30:35 Our most obvious intuitions may not be correct  31:00 Quantum Mechanics: Nature is radically and violently different from our intuition  36:00 Probability Matrices and margins of uncertainty  38:00 The wave particle duality and probability distributions  39:00 Why the relational interpretation is the best  46:00 Science is how you think about reality, not just maths  53:00 Our obsession with final truth is illusory, a silly dream  57:00 Buddha’s Dependent Origination + Nagarjuna’s emptiness  01:02:00 Intuition and altered states of consciousness  01:06:00 Psychedelics, insights and jumps of imagination  01:17:00 A scientific theory of meaning   01:26:00 An intro to Loop Quantum Gravity theory   References:  ‘Helgoland: The Strange and Beautiful Story of Quantum Physics’ , Carlo Rovelli  'The Order of Time’ , Carlo Rovelli  ‘The Fundamental Wisdom of the Middle Way: Nagarjuna’s Mulamadhyamakakarika’ , Nagarjuna  Empedocles - Greek philosopher  7 Brief Lessons in Physics’ , Carlo Rovelli  ‘Reality is not what it seems’ , Carlo Rovelli 

Lori Williams, expert in Controlled Remote Viewing (CRV), discusses the top-secret Stargate remote-viewing program, successful experiments during the Cold War, the importance of blindness in remote viewing, the challenges of remote viewing future events, the concept of living in a virtual reality, resistance to new ideas, skepticism and belief, and recommendations for further exploration

In this episode we have the fascinating proposition that what we call reality is in fact a hallucination we all agree on, to consider. We’ve already heard in this second series in Episode #28 from physicist Paul Davies on ‘The implications of Einstein’, that indeed matter is energy and as such the world we see as solid objects with space between them, isn’t truly like that. We’ve also heard from cognitive scientist Don Hoffman that we see the world optimised for ‘fitness’ in the evolutionary sense, and not for truth i.e not to see it as it actually is. So in the same vein in this episode we’re going to find out from a brilliant neuroscientist that we are in what he calls a ‘controlled hallucination’. That neuroscientist is none other than Anil Seth. Anil Seth is a professor of cognitive and computational neuroscience at the University of Sussex. He is also the co-director of the Sackler Centre for Consciousness Science. He has published over 100 scientific papers and is the editor-in-chief of the Oxford University Press publication ‘Neuroscience of Consciousness’. His TED talk ‘Your brain hallucinates your Conscious reality’ has more than 11 million views. His new book ‘Being You: a new science of consciousness’, which expands on most of what we’ll discuss today, is a Sunday times top 10 best seller, and a New statesmen, Economist and Bloomberg book of the year. I’ve wanted to speak with Anil since I heard about his theory, as it seemed to match some of my worries about the disconnect between what we perceive and what is actually there, and how much of what we see is coming from our own mental and biological state, and our biases at the time. What we discuss: 00:00 Intro 05:41 A ‘prediction machine’ perceiving from the inside-out, as well as perceiving sensory info outside-in. 10:00 Interoception: predictions about the body for self-control/regulation 14:00 The rubber-hand illusion: the prediction machine is not perfect 19:00 The risk of our best predictions being considered truth rather than hypothesis 23:00 Cultural humility about differences in our perceptions and beliefs 24:15 Why we call reality is a ‘controlled hallucination’ 31:30 The body has shaped the predictive brain for survival 34:00 Brain body bidirectionally vs reductionism 37:30 Supervenience 38:00 Can different levels of description be primary to each other? 46:00 The self is illusory References: Anil Seth's best seller, ‘Being you’ The Perception Census - Call for participants Immanuel Kant’s idea: Noumenon, ’the world is hidden behind a sensory veil’ Pareidolia - seeing patterns in things The Dream machine - Interactive flickering light experiment

The podcast explores the concept of free will and its connection to mindfulness meditation. They discuss the experimental evidence for the existence of free will and its implications for personal moral responsibility. The guests, including Susan Blackmore, share their insights on the illusion of free will and its compatibility with consciousness. The podcast also delves into the concept of dependent origination and explores the connection between separateness and oneness. They discuss the concept of form and emptiness and the challenge of studying consciousness without mental constructs.

In this episode we explore a User Interface Theory of reality. Since the invention of the computer virtual reality theories have been gaining in popularity, often to explain some difficulties around the hard problem of consciousness; but also to explain other non-local anomalies coming out of physics and psychology, like ‘quantum entanglement’ or ‘out of body experiences’.  As you will hear today the vast majority of cognitive scientists believe consciousness is an emergent phenomena from matter, and that virtual reality theories are science fiction or ‘Woowoo’ and new age. One of this podcasts jobs is to look at some of these Woowoo claims and separate the wheat from the chaff, so the open minded among us can find the threshold beyond which evidence based thinking, no matter how contrary to the consensus can be considered and separated from wishful thinking. So who better than hugely respected cognitive scientist and User Interface theorist Don Hoffman to clarify all this. Donald D Hoffman is a full professor of cognitive science at the University of California, Irvine, where he studies consciousness, visual perception and evolutionary psychology using mathematical models and psychophysical experiments. His research subjects include facial attractiveness, the recognition of shape, the perception of motion and colour, the evolution of perception, and the mind-body problem. So he is perfectly placed to comment on how we interpret reality. Hoffman is also the author of ‘The Case Against Reality’, the content of which we’ll be focusing on today; ‘Visual Intelligence’, and the co-author with Bruce Bennett and Chetan Prakash of ‘Observer Mechanics’. What we discuss: 11:20 Seeing the world for survival VS for knowing reality as it truly is 13:30 Competing strategies to maximise ‘fitness’ in the evolutionary sense 21:30 The payoff functions that govern evolution do not contain information about the structure of the world 29:30 Space-time cannot be fundamental 37:45 A User-Interface network of conscious agents 41:30 A virtual reality computer analogy 53:30 User Interface theory VS Simulation theory 01:08:00 The notion of truth is deeper than the notion of proof and theory 01:17:30 Is nature written in the language of Maths? 01:27:00 Consciousness is like the living being, and maths is like the bones 01:44:00 Being and experiencing being may co-arise 01:48:00 Different analogies for different eras References: Donald Hoffman - ‘The case against reality: Why evolution hid the truth from our eyes’ Nima Arkani-Hamed - ‘Space-time is dead’ Nima Arkani-Hamed - 'Reductionism is dead' Local Realism is false Noncontextual realism is false Don Hoffman - Objects of Consciousness paper Gödel’s Incompleteness Theorem

What are the implications of Einstein’s predictions? Has our understanding of reality integrated the implications of this thinking? His General and Special theories of relativity have completely changed the way we see gravity, energy, mass, space and time, even size - but how? Physicists may find it easy to understand what his ideas mean; like this quote “The distinction between the past, the present and the future is nothing but a stubbornly persistent illusion”. But for us, the general public, just thinking that the the arrow of time is an illusion, is enough to give us a bad headache and leave us wishing that Newton was right after all. But that’s not what we do on Chasing Consciousness, our mission is the same as always, to update our world view to match new theories. Now this sounds like no small feat, but have no fear, all will be be clarified by a man with a skill for presenting complex ideas in a way we can all understand, one of the worlds most published popular science writers, Professor Paul Davies. Paul Davies is a Cosmologist and Professor of Physics and Director of the Beyond Center for Fundamental Concepts in Science at Arizona State University. His work has covered topics as far reaching as Cosmology, Quantum Fields and Astrobiology, with a sprinkling of the Search for Extra terrestrial Intelligence (SETI) and cancer research to boot. He’s the bestselling author of almost thirty popular science books, his many awards include the Templeton Prize and the Faraday Prize of the Royal Society. He is a Member of the Order of Australia and even has an asteroid named after him! Quite a career! His new book ‘What’s eating the universe’, that covers many of the topics we’ll touch on today, is out now. What we discuss in this episode: 00:00 Intro 08:00 ‘The universe is about something’ 16:00 The warping of space time 22:00 The implications of gravity slowing time 31:25 Time and Space are relative, and can change and move like matter 36:00 Arrow of time VS Block time - ‘Time is just there’ 38:30 Matter is energy or Mass is a form of energy 42:00 The table isn’t solid, its mostly empty space 44:30 Did time start at the Big Bang? 49:00 Time doesn’t flow universally, it’s what clocks measure 52:00 3 big origin problems: the universe, life and consciousness 1:03:00 John Wheeler - the ‘bendy rubber’ analogy of space time 1:05:00 Einstein’s famous quotes explained 1:08:00 Intuition according to Einstein References: Paul Davies ‘What’s Eating the Universe: And other cosmic questions’ An Einstein Ring (A warping of space time) Full Isaac Newton quote, ’Absolute, true, and mathematical time, of itself, and from its own nature, flows equably without relation to anything external’ St Augustine quote ‘The world was made, not in time, but simultaneously with time’ Nima Arkani-Hamed ‘Space Time is Dead’ lecture (from 14.20) John Wheeler ‘Pregeometry’ Mach’s Principle