Empowered Patient Podcast

Vikram Bhaskran, CEO and Co-Founder, and Dr. Rohan Ramakrishna, Chief Medical Officer and Co-Founder of Roon, have taken on the mission to provide trustworthy and personalized medical information to patients and caregivers. Leveraging technology and the expertise of medical professionals, Roon has created a comprehensive resource for navigating medical challenges. They emphasize the importance of addressing misinformation and providing accurate, science-based information. The platform is not intended to replace doctors, but to supplement relevant information and enable better communication with healthcare providers and improve patient outcomes. Vikram explains, "Our mission is to be the best place online for anyone navigating any health condition. I started the company really through my own journey as a caregiver to my dad, who had ALS. And in that journey, I had two insights. One is that the biggest tech companies fail us. And in this moment of crisis, most people navigating any health condition will turn to "Doctor Google" and Facebook groups, which can be an overwhelming experience. And so I felt we could do better as someone coming from the tech world. I was at Pinterest before this, and my second insight was that there's a finite number of doctors. And so the experience of health today for really anyone is that you spend a ton of time in waiting rooms. You spend a ton of time waiting for someone to answer your health questions. And so Roon was born out of those two insights. And our goal is to be the best online platform to scale the world's best medical experts and their knowledge." Rohan elaborates, "The doctors are from more than 70 different academic medical institutions, and the number is growing. They represent all the experts who have expertise to share alongside the health journeys we've launched. So as of today, we've launched brain cancer, ALS, dementia, Fertility and Family Building, PCOS, endometriosis, menopause, and we are soon to launch several other conditions related to women's health, including gynecological health. Our experts span the doctors you would expect, such as oncologists, neurologists, and OBGYNs, among others, but also social workers, physical therapists, occupational therapists, speech therapists, and legal and financial counselors - really anyone who has real expertise that they can lend to the experience of a journey. So much of dementia care, for example, is not driven by your neurologist, but by the experience of caring for someone who needs help, whether it's at a memory care facility or a skilled nursing facility, dealing with issues that doctors typically don't have a great answer for." #Roon #HealthcareInformation #MedAI #HealthcareOutcomes #DigitalHealth roon.com Download the transcript here

Barry Quart, CEO of Connect Biopharma, is developing the next generation of monoclonal antibodies targeting inflammatory respiratory diseases such as COPD and asthma. Administered subcutaneously, their lead program targets IL-4 and has demonstrated the ability to rapidly improve airway function and reduce the incidence of acute exacerbations in these patients. Current treatments rely on steroids and bronchodilators, which do not address the underlying inflammatory causes, an area that has largely been under-addressed by other biologic developers. Barry explains, "Connect has been dedicated for quite a few years to designing next-generation monoclonal antibodies targeting inflammatory diseases. I joined the company last year and really kind of turned the ship towards a sole focus on our lead program, which is rademikibart, a second-generation Dupixent, a monoclonal antibody targeting IL-4, a really important target for certain inflammatory diseases." "IL-4 can be used as a monoclonal antibody targeting IL-4 for diseases such as atopic dermatitis, asthma, and COPD, as well as several other conditions. We're focused on asthma and COPD. So, inflammatory respiratory disease, because our product has some unique characteristics that are going to allow us to focus on an area that's really been completely ignored by other developers of biologics in the respiratory space, and specifically on patients having acute exacerbations." #ConnectBiopharma #MonoclonalAntibody #IL4 #COPD #Asthma #AtopicDermatitis #InflammatoryDiseases #RespiratoryDiseases connectbiopharm.com Download the transcript here

Dr. Kilian Kelly, Chief Executive Officer and Managing Director of Cynata Therapeutics, has taken on the challenge of manufacturing stem cell therapies consistently and at scale in order to drive the advancements necessary for the next generation of regenerative medicine. Cynata is employing a novel approach that utilizes a single source of pluripotent stem cells (iPSCs) and mesenchymal cell ancestors (MCAs) to generate mesenchymal stem cells (MSCs). Lead programs are targeting graft-versus-host disease, osteoarthritis, and diabetic wounds, where clinical trials have shown great promise to treat these and other diseases. Kilian explains, "We're a stem cell regenerative medicine company, and what we're trying to do is to change the way that we can manufacture stem cell therapies in a consistent and scalable way. I'm sure many of your listeners have heard about stem cell therapies of various types. The particular type of cells that we're working on are called mesenchymal stem cells or MSCs. They've shown lots of promise for lots of different purposes, but a real challenge has been making these cells consistently, especially when you try to do that at a large scale. We have a unique novel manufacturing platform, which helps us to address that major challenge." "The way that these cells were historically produced and indeed still are produced in most cases is by harvesting cells from, for example, somebody donating bone marrow or adipose tissue, also known as fat. And those approaches have certainly allowed a lot of early-stage clinical trials to be performed, which showed lots of really exciting results. But often what happens is that when you move to a larger scale using such a process, and you try to make much larger quantities of cells, perhaps using many different donors, you start to see a lot of inconsistency. There are a few reasons for this. When you have inconsistency with a product, it's inevitable that you're going to get inconsistent results." "If you have inconsistent results in a clinical trial, it becomes a bit of a lottery, and sometimes you can have very disappointing results that are hard to explain. So we think that's been a really big issue that has caused a lot of problems in the field. And aside from the impact on clinical trial results, we also need to think about the future when these products are available and on the market, and how you can actually, in practical terms, produce enough of these products. So, in a nutshell, I think that is probably the major challenge that the field has faced." #CynataTherapeutics #StemCellTherapy #RegenerativeMedicine #iPSCs #MSCs #MCAs Cynata.com Download the transcript here

Shauna Sweeney, Founder of tendercare, aims to assist caregivers with digital tools and expert support to simplify the process of caring for an aging family member. Recognizing the essential role of caregivers in the quality of life of the patient, tendercare provides a user-friendly interface that incorporates data from wearables and remote sensors to identify early warning signs of risks, help coordinate care, and encourage proactive preparation. The Magic Magnet feature allows caregivers and emergency responders to quickly update and share critical health information. Shauna explains, "This is not just a gendered issue. We have 54 million just Americans, if we keep it to the US, who are currently providing unpaid family care. This usually takes the form of anything from looking through bills, managing medications, renewing prescriptions, coordinating doctors' visits, and all other visits. Often, we find that those who are on our platform are the eldest child. So whether that's a daughter or a son, this is the type of person who is often leaning in to help. What is generally a parent or a grandparent who may or may not have the ability or the means to be able to get themselves to the doctor's appointments or pick up their prescriptions themselves, for instance." "Up until now, a lot of this has actually been human-powered. So, sitting down at the kitchen table with Mom and going through the mail to determine what needs to be paid by what time, but increasingly, because so many of us are living farther apart from one another, this is becoming more and more complicated. There is a level of coordination that we're all doing with one another, but we're often doing it over text. We're doing it over email, we're doing it over shared accounts and passwords. And so it's getting a lot more complicated, which is really where tendercare dropped in to try and help simplify a lot of this experience that so many of us are walking through right now." #Trytendercare #DigitalHealth #CareGiving #CareGivingTech #SmartCare #AginginPlace #HealthEquity trytendercare.com Download the transcript here

Karen Sussman Horgan is the Co-Founder and CEO of VAL Health, a behavioral economics consulting firm that helps healthcare organizations drive engagement and nudge patients to improve their health and lifestyle choices. Behavioral economics is the science of understanding how patients make irrational choices based on biases, fear, and faulty analysis of outcomes and risk. Nudges can be carrots or sticks, but in healthcare, the focus is on making the right path easier to follow, reducing friction, and introducing positive reinforcements rather than penalties. Karen explains, "We work across the entire healthcare ecosystem. We think about digital health companies, how do you drive enrollment and engagement, and how do you optimize the journey? There are communications for that. We do a lot of work with payers, which is closing gaps in care, but also just improving the member experience in general with providers. It could be around provider adoption of new care pathways, but it's also about population health. We work with employers on wellness programs and pharma on that adherence. So think about where information alone isn't driving people to think about their health or take care of themselves. We create the nudges to help make that happen." "It's the science of understanding that we as humans are irrational. We have a bias toward the present. We have an aversion to loss and regret. We overweight probability. There are dozens of known biases, and what we do is harness them rather than asking people to change their biases. So let me give you a few examples to bring this to light because right now people are probably like, What is a bias? So think about Netflix when you watch an episode. First of all, you have choice overload when you get there. So it's giving you recommendations, but it also defaults you into the next episode because it plays on the fact that we have a status quo bias, and we're lazy, and we're just going to sit there and binge-watch. " #VALHealth #BehavioralEconomics #BehavioralScience #BehaviorChange #DigitalHealth #Payers #HealthcareInnovation #HealthcareConsulting valhealth.com Download the transcript here

Christine Lee, Head of Health Strategy and Partnerships at AnalyticsIQ, focuses on helping healthcare brands and pharmaceutical companies better understand and engage with healthcare providers by taking into account data beyond their professional lives. This data-driven Provider as a Person approach analyzes the healthcare professional's personal characteristics, outside interests, decision-making style, and preferred method of communication. The goal is to foster more meaningful relationships with providers, address provider burnout, and improve patient outcomes. Christine explains, "We're coming into play here in supporting healthcare brands and better understanding the providers as people. As I mentioned, we're a people-based data company. I'd say that in an era where data is abundant and there is no shortage of health data being gathered and analyzed. So, you've got a lot of data assets out there that are coming from clinical trials, your real-world evidence, claims data, your electronic health records, all of which give insight into the aspects of a provider from a clinical setting. Traditionally, healthcare providers have been viewed primarily through the lens of their professional lives, their specialties, their role in patient care, prescription-writing behaviors, and even their affiliations. And these are super important factors. We do see those truly as table stakes, but they paint an incomplete picture." "Providers, like patients, have unique lives, needs, and preferences, which really shape how they interact with the work they do and the brands they seek to engage with. The industry is really recognizing these nuances, which presents a unique opportunity for healthcare brands to acknowledge the complexity of the providers' lives beyond what you could say are their white coat moments, and differentiate their message. And so this can dig into driving more meaningful engagement. And for us here at AnalyticsIQ, we're focused on helping to understand healthcare providers, or HCPs, more broadly, and understanding some of their personal characteristics. So, the data we're bringing to the table to complement all the other data in the ecosystem will be things like considering their work-life balance." #AnalyticsIQ #HealthcareData #HealthcareAnalytics #HealthTech #HCPengagement #PatientExperience #ValueBasedCare #PersonalizedCare #HealthEquity #SDOH #HealthcarePrivacy #PatientData analytics-iq.com Download the transcript here

Francisco Salva, President and CEO of Azitra, Inc., is leveraging the microbial bacteria that comprise the skin microbiome and exploring novel methods to deliver precision medicines to the skin. Azitra has genetically engineered specific strains of these microbes to produce proteins that are missing in patients with skin conditions like Netherton syndrome and cancer therapy-associated rashes. These bacterial strains have the ability to get beneath the stratum corneum and turn into miniature factories to make the therapeutic proteins and help the skin return to homeostasis. Francisco explains, "We're leveraging the billions of microbial bacteria that naturally live on us and are synergistic with our skin to help keep our skin in homeostasis or a regulated standard of existence. These bacteria makeup that are known as the skin microbiome, we have built up a library of these microbial bacteria strains commonly found on normal people and characterize them in a way that allows us to look for specific strains that may be able to deliver special proteins that may be missing or aberrantly made in the skin." "What we're leveraging is that microbial strain's ability to get past the outer protective layer of the skin called the stratum corneum. And these microbial strains get through that outer layer through intermittent spaces between the hair and that outer skin layer, the stratum corneum, and are able to get underneath the stratum corneum, grow, multiply, and colonize. And so by genetically engineering specific strains of these microbes, we're able to synthetically, or also known as recombinantly, make proteins that are missing in the patient's skin." "It's a little bit newer than the gut microbiome, and the field of study is also a little bit newer. And so the development of the understanding of the microbiome, which is what they call the defined consortia of various strains that normally live on us, is not quite as well elucidated as it is in the gut microbiome. That said, our mission at Azitra isn't to try to reset the entire regulation of the entire skin microbiome, but really just leverage specific strains of these bacteria that have the ability to get underneath that external layer of the skin." #RareDisease #OrphanDisease #Dermatology #SkinDisease #SkinDisorder #PrecisionsMedicine #PrecisionDermatology #PrecisionDerm #Netherton #NethertonSyndrome #Ichthyosis #CancerRash #EGFRiRash #EGFRiTreament azitrainc.com Download the transcript here

Dr. Quyen Nguyen, CEO and Founder of Alume Biosciences, is developing fluorescent-guided precision surgery technologies that enable surgeons to visualize critical structures, such as nerves, blood vessels, and tumor margins, more clearly during procedures. Alume is developing fluorescent dyes and imaging systems to support this approach, building on work by Roger Tsien who won the Nobel Prize for fluorescence. This technology has the potential to enable more complex surgical procedures to be performed safely in brain, head, neck, and abdominal surgeries and has the promise to transform surgery. Quyen elaborates, "I first met Roger Tsien Nobel Laureate for his work in fluorescence, in 2001. I had worked with green fluorescent protein, one of the things that he was working on for fluorescence, and he ultimately was awarded the Nobel Prize for fluorescence. And I asked him, 'Roger, is there a way we can make nerves fluorescent in patients? We certainly have that in research, but surgeons don't have this tool now.' And he said, 'What, no one's done that yet?' And so that's the beginning of our story together. I see that the use of fluorescence is going to be transformative in the field of surgery. Who wants to turn off the light and see if surgeons can see and operate in the dark? So I feel like fluorescence is just another level of light that allows you to see structures more precisely." "Of course, you want to see structures more precisely so you can continue to carry on your work, tumor resection, reconstructive surgery, or any other procedures that patients are undergoing. Of course, you want to see tumor margins more clearly. Of course, you want to see arteries and veins and so forth. Of all the structures that we work on, I would say that nerves are considered the holy grail of surgery, partly because they're so delicate. One or two millimeters can take away somebody's ability to have urinary continence or erectile function or the ability to smile." #AlumeBiosciences #FluorescentGuidedSurgery #PrecisionSurgery #HeadNeckSurgery AlumeBiosciences.com Download the transcript here

Rob Armstrong, CEO of Artax Biopharma, highlights the basic mechanism of action of Nck modulators and how they differ from traditional immunosuppressant drugs to treat autoimmune diseases. Taking this adjustable thermostat approach aims to modulate the immune response rather than completely suppressing the response, potentially reducing side effects. The oral, small molecule drug is an advantage over injectable biologics currently dominating the automimmune disease treatment landscape. Rob explains, "Nck stands for non-catalytic kinase, and what Nck is is an adapter protein that interacts with the T cell receptor. Its role is basically to amplify any signals when an antigen is presented to the T cell receptor. It's really interesting because it's called signal one. In other words, it's the beginning of the immune cascade when an antigen is presented. And what's interesting is that it's upstream of what the target of most other drugs are, which are the cytokines that are the offending entities for many of the autoimmune diseases. So what Nck does basically is it amplifies different types of antigens that are bound to the T cell receptor." "So, T cell receptors are a fascinating construct of proteins because they need to address the binding of antigens that are across an incredibly different range of avidity. In other words, it has to be able to be activated by both very strong avidity antigens and weak antigens. So what Nck does is it amplifies the signal when the antigen is a weak antigen, but when it's a strong antigen, Nck is really not necessary at all. And that particular distinction is why we modulate the immune system instead of suppressing it." #ArtaxPharma #AutoimmuneDiseases #AtopicDermatitis #immunomodulation #NckModulators #TCellActivation #psoriasis #Dermotology artaxbiopharma.com Download the transcript here

Shyam Natarajan, Founder and CEO of Avenda Health, is utilizing the Unfold AI platform that combines imaging, pathology, and clinical data to provide a comprehensive 3D visualization of prostate cancer. This platform has demonstrated significantly higher accuracy than conventional imaging techniques, enabling physicians to make more informed diagnoses and treatment decisions. The technology has been integrated into the clinical workflow to provide real-time insights and precision-guided interventions, minimizing treatment-related side effects and preserving patient quality of life. Shyam explains, "Unfold AI is unique in that it's multimodal. We take in imaging biomarkers, pathology, and clinical information as input. And conventional imaging really doesn't show you exactly everywhere the cancer is. MRI today misses two-thirds of the disease by volume, and so imaging is really good at screening and that initial diagnosis. But when it comes time to decide how to treat patients, the standard of care is challenging today because, really, up to a third of patients end up having cancer left behind after treatment. So what we're trying to solve is this pain point where cancer is missed, and as a consequence, cancer is left behind." "This product is really for patients who have a diagnosis of what we call clinically significant or cancer that you have to do something about. So, it's not the very low-risk, where being on what's called surveillance, watch and wait, is probably more appropriate. But this product, you touched upon the value proposition where a lot of patients are coming to their doctor saying, Hey Doc, I don't want to get surgery because I'm scared of the quality of life outcomes or the side effect profile. They want to get a targeted therapy. Well, physicians really can't offer targeted therapy in a broad sense unless they know where the cancer is. And so, AI is empowering and enabling physicians to perform precision-guided therapy or focal therapy." #AvendaHealth #UnfoldAi #ProstateCancer #ProstateCancerTreatment #HealthcareAI #CancerAI #RadiologyAI #DiagnosticAI #MedicalAI #AIinHealthcare avendahealth.com Download the transcript here