Mind & Matter

Nick Jikomes
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Nov 6, 2024 • 1h 9min

Kidney Biology: Simple Diet & Lifestyle Practices for Kidney Health | Thomas Weimbs | 186

Send us a textAbout the guest: Thomas Weimbs, PhD is a biologist at UC-Santa Barbara whose lab studies kidney function in health and disease.Episode summary: Nick and Dr. Weimbs discuss: basic kidney biology; kidney stones and their causes, including dietary oxalates and fructose; the kidney damaging effects of common pharmaceuticals like Ibuprofen; the beneficial effects of BHB and ketosis for kidney health; the myth that high protein intake is bad for the kidney; kidney diseases and their causes; and more.Full version available on Substack and YouTube.Related episodes:M&M 158: Ketosis & Ketogenic Diet: Brain & Mental Health, Metabolism, Diet & Exercise, Cancer, Diabetes | Dominic D'AgostinoM&M #139: Metabolic Switching, Fasting, Ketosis, Neuroplasticity, Diet & Neurodegenerative Disease | Mark Mattson*This content is never meant to serve as medical adviceSupport the showAffiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts
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Oct 31, 2024 • 43min

Self-Experimentation (n=1) in Metabolic Health, Lipid-Energy, Trust in Medical Institutions | Nick Norwitz | 195

Send us a textFull version available on Substack and YouTube.About the guest: Nick Norwitz, PhD received his PhD in Physiology at Oxford University and is finishing his MD degree at Harvard Medical School. He is also an independent content creator focused on making metabolic health mainstream.Episode summary: Nick and Dr. Norwitz discuss: blood lipids & cholesterol; high cholesterol levels and what they can mean for different people; the “lean mass hyper-responder” phenotype to carb restriction; ketogenic & carnivore diets; public trust in medical & science institutions; n=1 (“n of one”) science experiments; and more.Related episodes:M&M 158: Ketosis & Ketogenic Diet: Brain & Mental Health, Metabolism, Diet & Exercise, Cancer, Diabetes | Dominic D'Agostino*This content is never meant to serve as medical adviceSupport the showAffiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts
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Oct 30, 2024 • 1h 4min

Sugar & Sweeteners: Are They Really Addictive or Unhealthy? | Nicole Avena | 185

Send us a textFull version available on Substack and YouTube.About the guest: Nicole Avena, PhD is a neuroscientist at Mount Sinai. She studies the effects of sugar and diet on animal behavior and the brain. She is also the author of, “Sugarless.”Episode summary: Nick and Dr. Avena discuss: drug addiction vs. food addiction; glucose, fructose & artificial sweeteners; the extent to which sugar consumption can drive dependency & withdrawal; fructose metabolism & live health; sweetness & palatability; ultra-processed foods; and more.Related episodes:M&M 140: Obesogens, Oxidative Stress, Dietary Sugars & Fats, Statins, Diabetes & the True Causes of Metabolic Dysfunction & Chronic Disease | Robert Lustig*This content is never meant to serve as medical adviceSupport the showAffiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts
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Oct 27, 2024 • 1h 7min

Endocrine Disruptors & Metabolism: Microplastics, BPA, Estrogen, Insulin, Pancreas & Metabolic Dysfunction | Angel Nadal | 184

Angel Nadal, a Spanish biologist specializing in endocrine disruptors and pancreatic functions, discusses the intricate relationship between microplastics, BPA, and hormone signaling. He dives into how these disruptors impact insulin signaling and metabolic health, emphasizing their effects on both males and females. The conversation touches on the critical role of estrogen in metabolism and how BPA can influence developmental outcomes during pregnancy. Nadal also highlights sex differences in responses to endocrine disruptors, offering insights into gender-specific health implications.
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Oct 23, 2024 • 59min

Calorie Restriction & Fasting: Aging, Immunity, Health Biomarkers, Stress, Genetics | Gary Churchill | 183

Send us a textAbout the guest: Gary Churchill, PhD is a statistician & geneticist at the Jackson Research laboratory in Maine. His lab uses a systems approach to investigate the genetics of complex biological traits in health & disease.Episode summary: Nick and Dr. Churchill discuss: his recent papers looking at the effects of caloric restriction & intermittent fasting on nearly 1,000 genetically diverse mice; how dietary restrictions affect longevity, metabolic health, immunity, and hundreds of biomarkers; the role of genetics vs. diet in aging; and more.Related episodes:M&M #139: Metabolic Switching, Fasting, Ketosis, Neuroplasticity, Diet & Neurodegenerative Disease*This content is never meant to serve as medical advice.*Full episode available free on Substack & YouTube.Support the showAffiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts
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Oct 19, 2024 • 1h 12min

Neural Basis of Language in the Human Brain | Ev Fedorenko | 182

Ev Fedorenko, a neuroscientist at MIT, delves into the intricate relationship between language, thought, and the brain. She explores the fascinating dynamics of language processing and its neural networks. The discussion touches on Noam Chomsky's Universal Grammar theory, the Sapir-Whorf hypothesis, and the differences in language acquisition between children and adults. Fedorenko also challenges the distinctions between human and animal communication, revealing how language reflects complex cognitive processes while examining ambiguities that aid in learning and communication.
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Oct 15, 2024 • 1h 4min

Neurosurgery, Blood-Brain Barrier, Ultrasound Technology for Brain Diseases & Disorders | Nir Lipsman | 181

Send us a textAbout the guest: Nir Lipsman, MD, PhD is a neurosurgeon and neuroscientist at the University of Toronto.Episode summary: Nick and Dr. Lipsman discuss: neurosurgery; the blood-brain barrier and how it works; using focused ultrasound technology to non-invasively treat patients; regulatory impediments to clinical research; costs, constraints, and future applications of ultrasound tech for treating psychiatric conditions; and more.Related episodes:M&M #168: Sleep: Neural Circuits, Orexin/Hypocretin, Hypothalamus, Neuromodulators, Stress & Cortisol, Sleep Drugs & Ultrasound Technology | Luis de Lecea*This content is never meant to serve as medical advice.Support the showAffiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts
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Oct 11, 2024 • 1h 20min

Mother-Infant Bonding, Maternal Care & Breastfeeding, Neural Basis of Hunger & Social Behavior | Marcelo Dietrich | 180

Send us a textAbout the guest: Marcelo Dietrich, MD, PhD is an associate professor in Comparative Medicine & Neuroscience at Yale University, where his lab studies the neural basis of behavior in mammals.Episode summary: Nick and Dr. Dietrich discuss: maternal care behavior, mother-infant bonding, and feeding in infant mammals; neural circuits regulating hunger & satiety; brain development & early social learning; behavioral variability among individuals; and more.Related episode:M&M #108: Monogamy, Sexual & Parental Behavior, Social Attachment, Oxytocin, Sex Hormones, Childhood Psychosis, Menopause & Brain Development | Devanand Manoli*This content is never meant to serve as medical advice.Support the showAffiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts
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Oct 8, 2024 • 1h 19min

Cave Art, Archaeology & the Emergence of Modern Humans | Maxime Aubert | 179

In this episode, guest Maxime Aubert, a geochemist and archaeologist from Griffith University, dives into the world of ancient cave art and human evolution. He reveals insights about the oldest known cave art and its implications for modern human cognition. The discussion highlights the significance of artistic expressions in understanding human migration and creativity, particularly in France's Chauvet Cave and Sulawesi's ancient sites. Aubert shares innovative dating techniques that are reshaping our understanding of prehistoric societies and the role of art in early human life.
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Sep 27, 2024 • 33min

Ask Me Anything 1 | Nick Jikomes

Send us a textAbout the guest: Nick Jikomes, PhD is the creator and host of the podcast. You can read more about him here.Episode summary: Nick answers questions from listeners on topics such as: his scientific background & interests; staying up-to-date on research & selecting guests; thoughts on psychedelic science & drug use; questions related to diet, metabolic health & fat loss; controversial ideas worth considering; and more.*This content is never meant to serve as medical advice.Support the showAffiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

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