

Mind & Matter
Nick Jikomes
Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it.The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today.Not medical advice.At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it.As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet.I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint.My beliefs:Taking ownership of your health starts with taking ownership of your information diet.All knowledge is provisional and we must work hard to prevent ourselves from becoming attached to our favorite ideas & preferred conclusions.Wisdom comes from an iterative, trial-and-error process of learning and unlearning. Letting go of pre-conceived notions can be painful, but pain is information.Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi:“Γνῶθι σεαυτόν” (Know thyself)“Μηδὲν ἄγαν” (Nothing in excess)“Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)
Episodes
Mentioned books

Feb 6, 2021 • 1h 12min
Empathy, Addiction, MDMA ("Ecstasy"), Psychedelics & Social Cognition | Katrin Preller | 8
Send us a textNick talks to neuropsychologist Katrin Preller, PhD about psychedelics like LSD and psilocybin, empathogens like MDMA, and stimulants like cocaine. Katrin explains how each type of drug affects the brain differently and what that means for their impact on empathy, social cognition, and their addictive potential.*Not medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. AquaTru: Reverse osmosis water filters. Remove metals, microbes, endocrine disruptors and toxins from drinking water. $100 off AquaTru filters through link. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

Jan 30, 2021 • 1h 36min
Salvia divinorum, Dissociation & Psychotherapy | Peter Addy | 7
Send us a textNick talks to Peter Addy, PhD about the atypical, dissociative psychedelic, salvia. Peter is a psychotherapist and spent several years at the Yale, studying human experiences with atypical psychedelics such as Salvia divinorum. Nick and Peter talked about salvia, including how it works and how it differs from other psychedelics, as well as dissociative and dysphoric effects, and how his research has informed his psychotherapy practice. *Not medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. AquaTru: Reverse osmosis water filters. Remove metals, microbes, endocrine disruptors and toxins from drinking water. $100 off AquaTru filters through link. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

7 snips
Jan 23, 2021 • 2h 9min
Psychedelics, DMT, Ayahuasca, Ibogaine, Amphetamines & Hamilton's Pharmacopeia | Hamilton Morris | 6
Send us a textNick talks to Hamilton Morris, creator of the show, "Hamilton's Pharmacopeia," about the third and final season. They discuss: the last season of his show, including the content itself and what it took to actually make it; a variety of drugs and their effects, ranging from stimulants like methamphetamine, dissociatives (e.g. ketamine), psychedelics & to various forms of DMT, ibogaine and xenon gas.*Not medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. AquaTru: Reverse osmosis water filters. Remove metals, microbes, endocrine disruptors and toxins from drinking water. $100 off AquaTru filters through link. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

Jan 16, 2021 • 2h 43min
Cannabis Science, Plant Chemistry & Marijuana Startups | Jon Page | 5
Send us a textJonathan Page, PhD is a botanist and entrepreneur with deep expertise in Cannabis. Nick and Jon talked about all things Cannabis science including the botany and natural history of Cannabis, the chemistry and biology of Cannabis and its psychoactive effects, and whether or not different types of Cannabis can cause different effects. Jon also shared amazing stories about transitioning from scientific research to starting, building, and selling a cannabis company, and his thoughts on what’s next for the cannabis industry. *Not medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. AquaTru: Reverse osmosis water filters. Remove metals, microbes, endocrine disruptors and toxins from drinking water. $100 off AquaTru filters through link. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

Jan 9, 2021 • 1h 49min
Drugs, Brain Receptors, Zen Meditation, Nondualism & Psychedelics | Bryan Roth | 4
Send us a textBryan Roth, MD, PhD discusses his career studying how psychedelics and other psychoactive drugs affect the brain, the massive $27 million research effort he is leading to understand psychedelics and develop novel drugs for psychiatric disease, and the practice of zen meditation.*Not medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. AquaTru: Reverse osmosis water filters. Remove metals, microbes, endocrine disruptors and toxins from drinking water. $100 off AquaTru filters through link. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

Jan 1, 2021 • 1h 37min
Chance, Evolution & the Nature of Innovation | Sean B. Carroll | 3
Send us a textSean B. Carroll, PhD is an award-winning biologist, author, and filmmaker. Nick and Sean discuss everything from Sean's unique career trajectory and writing process, to dinosaurs and snake venom, to COVID19, the evolution of viruses, and why comedians and scientists are kindred spirits. Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. AquaTru: Reverse osmosis water filters. Remove metals, microbes, endocrine disruptors and toxins from drinking water. $100 off AquaTru filters through link. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

Dec 25, 2020 • 1h 53min
Psilocybin, LSD, Ketamine, DMT Facts & Myths, Inflammation & Novel Psychedelic Medicines | Charles Nichols | 2
Send us a textDr. Nichols is a professor of pharmacology at Louisiana State University. He has been studying the molecular, genetic, and behavioral effects of psychedelics for nearly 25 years and is considered one of the world’s top experts on the biological effects of psychedelics in the brain and body.Nick spoke to Charles for almost two hours, covering a wide range of topics related to how psychedelics work. They discuss everything from how psychedelics impact the serotonin system in the brain, the similarities and differences between drugs like psilocybin and ketamine, how microdosing specific psychedelics can lead to potent anti-inflammatory effects, and much more.*Not medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. AquaTru: Reverse osmosis water filters. Remove metals, microbes, endocrine disruptors and toxins from drinking water. $100 off AquaTru filters through link. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

Dec 14, 2020 • 1h 30min
Psychedelics, Civilization, Religion, Ancient History, Plant Medicine & Death | Brian Muraresku | 1
Send us a textBrian is the author of the New York Times-bestselling book, "The Immortality Key: The Secret History of the Religion With No Name." Brian is fluent in Ancient Greek, Latin, and Sanskrit, and spent over a decade putting together an incredible story about the intentional use of psychoactive plants in the ancient world, including scientific evidence for the ritual use of spiked beers and wines. Nick and Brian cover topics related to his book, including the use of psilocybin mushrooms in the present to treat end of life anxiety, how “Mystery Schools” in the ancient Greco-Roman world, such as Eleusis, may have utilized psychedelic beverages, the evidence for the potential widespread use of psychoactive plants in ritual settings in ancient times, and how this may have influenced early Christianity, and how psychedelic drugs may induce brain states similar to those produced in near-death experiences.*This content is never meant to serve as medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. AquaTru: Reverse osmosis water filters. Remove metals, microbes, endocrine disruptors and toxins from drinking water. $100 off AquaTru filters through link. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts