The Bob Harrington Show

Trials on lowering salt consumption and treating hypertension in the community impressed Drs Harrington and Gibson in this discussion of the best public health research of 2021. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit: https://www.medscape.com/author/bob-harrington CV Public Health Trials Interim effects of salt substitution on urinary electrolytes and blood pressure in the China Salt Substitute and Stroke Study (SSaSS) https://doi.org/10.1016/j.ahj.2019.12.020 A Cluster Randomized Trial of a Village Doctor-Led Intervention on Blood Pressure Control: China Rural Hypertension Control Project https://www.abstractsonline.com/pp8/?_ga=2.141042993.2042594723.1635046736-1021258137.1633710264#!/9349/presentation/18155 A Remotely Delivered Hypertension and Lipid Program in 10,000 Patients Across a Diverse Health Care Network https://www.abstractsonline.com/pp8/?_ga=2.141042993.2042594723.1635046736-1021258137.1633710264#!/9349/presentation/18153 COVID-19 Public Health Trials Impact of community masking on COVID-19: A cluster-randomized trial in Bangladesh https://www.poverty-action.org/publication/impact-community-masking-covid-19-cluster-randomized-trial-bangladesh Dexamethasone in Hospitalized Patients with Covid-19 https://doi.org/10.1056/NEJMoa2021436 Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19 https://jamanetwork.com/journals/jama/fullarticle/2775280 The Recovery Trial Initiative https://www.recoverytrial.net/results You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Drs Harrington and Gibson provide their annual roundup of what they consider the key cardiovascular trials of 2021. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit This podcast is intended for US healthcare professionals only. To read a full transcript of this episode or to comment please visit: https://www.medscape.com/viewarticle/963475 https://www.medscape.com/author/bob-harrington Antiplatelet Therapy Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease https://doi.org/10.1056/NEJMoa2102137 Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk https://doi.org/10.1056/NEJMoa2108749 Effect of 1-Month Dual Antiplatelet Therapy Followed by Clopidogrel vs 12-Month Dual Antiplatelet Therapy on Cardiovascular and Bleeding Events in Patients Receiving PCI https://doi.org/10.1001/jama.2019.8145 Aspirin Versus Clopidogrel for Chronic Maintenance Monotherapy After Percutaneous Coronary Intervention (HOST-EXAM): An Investigator-Initiated, Prospective, Randomised, Open-Label, Multicentre Trial https://doi.org/10.1016/S0140-6736(21)01063-1 SGLT2 Inhibitors and GLP-1 Agonists Empagliflozin in Heart Failure with a Preserved Ejection Fraction https://www.nejm.org/doi/full/10.1056/NEJMoa2107038 Once-Weekly Semaglutide in Adults with Overweight or Obesity https://www.nejm.org/doi/full/10.1056/NEJMoa2032183 Cardiac Surgery and PCI Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke https://doi.org/10.1056/NEJMoa2101897 Concomitant Tricuspid Repair in Patients with Degenerative Mitral Regurgitation https://doi.org/10.1056/NEJMoa2115961 Fractional Flow Reserve–Guided PCI as Compared with Coronary Bypass Surgery https://doi.org/10.1056/NEJMoa2112299 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback? Please contact news@medscape.net

Instead of trying therapies and hoping for the best, the RECOVERY trial investigators designed randomized trials to test which therapeutics were truly effective for COVID-19. Dr Harrington interviews lead investigator Martin Landray, MB ChB, PhD. To read a transcript or to comment: https://www.medscape.com/author/bob-harrington The Bob Harrington Show is intended for healthcare professionals. RECOVERY Trial Website and Some Publications Randomized Evaluation of COVID-19 Therapy https://www.recoverytrial.net/ Dexamethasone in Hospitalized Patients with Covid-19 https://www.nejm.org/doi/full/10.1056/nejmoa2021436 Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial https://doi.org/10.1016/S0140-6736(20)32013-4 Remdesivir for the Treatment of Covid-19 — Final Report https://www.nejm.org/doi/full/10.1056/nejmoa2007764 Dexamethasone in Hospitalized Patients with Covid-19 https://www.nejm.org/doi/full/10.1056/nejmoa2021436 Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19 https://www.nejm.org/doi/full/10.1056/NEJMoa2022926 Clinical Trials and Informed Consent The good Clinical Trials Collaborative https://www.goodtrials.org/ Why do we need some large, simple randomized trials? https://doi.org/10.1002/sim.4780030421 Assessment of Length and Readability of Informed Consent Documents for COVID-19 Vaccine Trials http://jamanetwork.com/article.aspx?doi=10.1001/jamanetworkopen.2021.10843 You may also like: Medscape Editor-in-Chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback? Please contact: news@medscape.net

A genomics giant with a family history of heart disease and an Olympic athlete accused of cheating are just two of the medical mysteries unraveled by DNA analysis. Bob Harrington interviews Euan Ashley, author of The Genome Odyssey: Medical Mysteries and the Incredible Quest to Solve Them (https://us.macmillan.com/books/9781250234995), who was inspired to write the book after watching an interview between "fellow nerds" Atul Gawande and Barack Obama. To read a transcript or to comment https://www.medscape.com/author/bob-harrington The Book The Genome Odyssey: Medical Mysteries and the Incredible Quest to Solve Them https://us.macmillan.com/books/9781250234995 The People Stephen Quake Clinical assessment incorporating a personal genome https://doi.org/10.1016/s0140-6736(10)60452-7 Leilani Graham https://www.leilanirgraham.com/ Eero Mäntyranta https://theolympians.co/2018/01/22/eero-mantyranta-the-ruddy-cheeks-and-the-genetic-advantange-of-a-cross-country-skiing-legend-from-finland/ You may also like: Medscape Editor-in-Chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine Hear Dr John Mandrola's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

What is the incidence of post-COVID myocarditis and when is it safe to return to play? Bob Harrington and Manesh Patel discuss our evolving understanding of how SARS-CoV-2 effects the hearts of athletes and weekend warriors. To read a transcript or to comment https://www.medscape.com/author/bob-harrington Early Studies Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19) https://doi.org/10.1001/jamacardio.2020.3557 Cardiovascular Magnetic Resonance Findings in Competitive Athletes Recovering From COVID-19 Infection https://doi.org/10.1001/jamacardio.2020.4916 Pooled autopsy https://www.medscape.com/viewarticle/944496 Pathological Evidence for SARS-CoV-2 as a Cause of Myocarditis: JACC Review Topic of the Week https://doi.org/10.1016/j.jacc.2020.11.031 Lake Louise Criteria https://pubmed.ncbi.nlm.nih.gov/30545455/ Recognition and Initial Management of Fulminant Myocarditis A Scientific Statement From the American Heart Association https://doi.org/10.1161/CIR.0000000000000745 Long-Haul Post–COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrome: The Swedish Experience https://doi.org/10.1016/j.jaccas.2021.01.009 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Bob Harrington and Mike Gibson continue their review of 2020, discussing the 'riddle wrapped in an enigma' that was the COVID-19 pandemic.

The annual tradition continues as did cardiology research despite a pandemic. Trials on fish oils, statins, SGLT2 inhibitors, and antiplatelets are among the selections of Drs Harrington and Gibson.

Three editors of cardiology journals -- Drs Harrington, Yancy, and Nallamothu -- discuss the challenges of maintaining quality during the COVID-19 surge in submissions.

Hematologist Mary Cushman discusses arterial and venous thrombosis issues with SARS-CoV-2 and the role of anticoagulation.

Bob Harrington asks Michelle Albert why mortality rates are so high in minority communities, and whether COVID-19 will lead to meaningful changes in health and social inequities.