
MeSsy with Christina Applegate & Jamie Lynn Sigler
On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.
Latest episodes

Jun 25, 2024 • 1h 1min
Sadie
This week, Christina and Jamie are joined by a very special guest... Christina's daughter Sadie. She opens up about some of her own health challenges, what it's like to be the daughter of someone with MS, what it's like to be a thirteen year old right now, and much more.Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Vuori - Go to vuori.com/MESSYOne Skin - For a limited time, you can try OneSkin for 15% off using the code MESSY at oneskin.coAG1 - drinkag1.com/messy

Jun 18, 2024 • 56min
Sh*t Happens
This week, Christina and Jamie discuss the importance of not holding things in, the stages of grief, finding people to lean on, and more.Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Cionic - MeSsy listeners can get $50 off by entering the code MESSY during checkout Visit cionic.com/messy Honeylove - For a limited time only you can get Honeylove on sale. Get 20% Off your entire order with our exclusive link honeylove.com/messy

Jun 11, 2024 • 1h 5min
Jennifer Esposito
This week, Christina and Jamie are joined by Jennifer Esposito. Jennifer opens up about her celiac disease and the struggle she went through to get a diagnosis. They also discuss the gaslighting of women, the importance of fighting for your health, her new film "Fresh Kills," and much more.Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis show is sponsored by:Vuori- Messy listeners get 20% off your FIRST purchase at Vuori.com/MESSY and enjoy free shipping on any U.S. orders over $75 and free returnsFatty15- Fatty15 is on a mission to replenish your C15 levels and restore your long-term health.Get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/MESSY and use code MESSY at checkoutBetterHelp - Messy is sponsored by/brought to you by BetterHelp. Give online therapy a try at betterhelp.com/messy and get on your way to being your best self.Zoc Doc - Go to Zocdoc.com/MESSY and download the Zocdoc app for FREE. Then find and book a top-rated doctor today.

Jun 4, 2024 • 54min
You Get What You Give
This week, Christina and Jamie discuss feeling trapped, missing high heels, their favorite shows that they’ve worked on, and more.This episode was recorded in early 2024.Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:AG1 - Try AG1 and get a FREE 1-year supply of Vitamin D3K2 AND 5 free AG1 Travel Packs with your first purchase at drinkAG1.com/messy. That’s drinkAG1.com/messy.Lume - New customers GET 15% ALL Lume products with code MESSY- and if you combine the 15% off with the already discounted starter pack, that equals over 40% off their Starter Pack! Use code MESSY for 15% off your first purchase at LumeDeodorant.com. BetterHelp - Messy is sponsored by/brought to you by BetterHelp. Give online therapy a try at betterhelp.com/messy and get on your way to being your best self.

May 28, 2024 • 1h 13min
Katie Couric
This week, Christina and Jamie are joined by Katie Couric. They discuss the importance of community and honesty, why we need more collaboration over competition, the changing media landscape, and more. Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis show is sponsored by:Maybelline - If you, or someone you know is experiencing anxiety or depression, Maybelline New York is funding free, confidential support: Text TOGETHER to 741741 or visit Maybelline.com/bravetogether to learn moreLolavie -Get 15% off LolaVie with the code MESSY at https://www.lolavie.com/MESSY #lolaviepod Cionic - MeSsy listeners can get $50 off by entering the code MESSY during checkout visit cionic.com

May 21, 2024 • 57min
Jean Smart
This week, Christina and Jamie are joined by Jean Smart. They share memories from when Christina and Jean worked together, and discuss taking back your power, embracing the quiet moments, her career trajectory, and much more.Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis show is sponsored by:Maybelline- If you, or someone you know is experiencing anxiety or depression, Maybelline New York is funding free, confidential support: Text TOGETHER to 741741 or visit Maybelline.com/bravetogether to learn moreVuori -Get 20% off your FIRST purchase of the most comfortable and versatile clothing on the planet at vuori.com/MESSYZoc Doc - Go to Zocdoc.com/MESSY and download the Zocdoc app for FREE. Then find and book a top-rated doctor today.

May 14, 2024 • 56min
Body Talk
This week, Christina and Jamie open up about their battles with eating disorders and self-esteem. They reflect on the moments that changed their lives, and discuss body dysmorphia, societal conditioning, how they each got to a healthier place, and more.*Trigger warning: discussion covers eating disorders and body image*Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Maybelline: If you, or someone you know is experiencing anxiety or depression, Maybelline New York is funding free, confidential support: Text TOGETHER to 741741 or visit Maybelline.com/bravetogether to learn moreBetterHelp: This episode is sponsored by BetterHelp. Give online therapy a try at betterhelp.com/messy and get on your way to being your best self.”Cionic - MeSsy listeners can get $50 off by entering the code MESSY during checkout visit cionic.com

May 7, 2024 • 1h 5min
How Did You Know?
This week, Christina and Jamie discuss giving up control, feeling judgement, and Jamie shares how she knew to get tested for MS. They also answer some listener questions.Parts of this episode were recorded in 2023.Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Maybelline: If you, or someone you know is experiencing anxiety or depression, Maybelline New York is funding free, confidential support: Text TOGETHER to 741741 or visit Maybelline.com/bravetogether to learn moreLume: Control Body Odor ANYWHERE with @lumedeodorant and get 15% off with promo code messy at LumeDeodorant.com! #lumepodVuori: For our listeners, they are offering 20% off your FIRST purchase. Get yourself some of the most comfortable and versatile clothing on the planet at vuori.com/MESSYBetterHelp: This episode is sponsored by BetterHelp. Give online therapy a try at betterhelp.com/messy and get on your way to being your best self.

Apr 30, 2024 • 53min
Jimmy Kimmel
This week, Christina and Jamie are joined by their friend, Jimmy Kimmel. They discuss finding humor in tough situations, the things he still wants to accomplish, speaking from your heart, mean tweets, and much more.Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis show is sponsored by:Maybelline - If you, or someone you know is experiencing anxiety or depression, Maybelline New York is funding free, confidential support: Text TOGETHER to 741741 or visit Maybelline.com/bravetogether to learn moreLolavie - Get 15% off LolaVie with code MESSY at https://www.lolavie.com/MESSY! #lolaviepodZocDoc - Go to Zocdoc.com/MESSY and download the Zocdoc app for FREE. Then find and book a top-rated doctor today

Apr 23, 2024 • 49min
Can I Be Honest?
This week, Christina and Jamie discuss feeling obligated to be strong, the importance of being there for each other, wearing diapers, and much more. They also answer some listener questions.Parts of this episode were recorded in 2023.Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Maybelline - If you, or someone you know is experiencing anxiety or depression, Maybelline New York is funding free, confidential support: Text TOGETHER to 741741 or visit Maybelline.com/bravetogether to learn more.Cionic - MeSsy listeners can get $50 off by entering the code MESSY during checkout visit cionic.comJamie-Lynn Sigler is a paid spokesperson for Novartis. This podcast is independent from Jamie-Lynn Sigler’s collaboration with Novartis.