Today we’re talking about uses for Go in the medical industry. Tim Stiles develops and maintains a Go package for synthetic biology and molecular biology called Poly. It has broad applications for biotech R&D, but also has very direct applications to medicine. Join the discussionChangelog++ members save 4 minutes on this episode because they made the ads disappear. Join today!Sponsors:Sourcegraph – Transform your code into a queryable database to create customizable visual dashboards in seconds. Sourcegraph recently launched Code Insights — now you can track what really matters to you and your team in your codebase. See how other teams are using this awesome feature at about.sourcegraph.com/code-insights Square – Develop on the platform that sellers trust. There is a massive opportunity for developers to support Square sellers by building apps for today’s business needs. Learn more at changelog.com/square to dive into the docs, APIs, SDKs and to create your Square Developer account — tell them Changelog sent you. Retool – The low-code platform for developers to build internal tools — Some of the best teams out there trust Retool…Brex, Coinbase, Plaid, Doordash, LegalGenius, Amazon, Allbirds, Peloton, and so many more – the developers at these teams trust Retool as the platform to build their internal tools. Try it free at retool.com/changelog Featuring:Tim Stiles – Twitter, GitHubNatalie Pistunovich – Twitter, GitHubIan Lopshire – Twitter, GitHubShow Notes: Poly on GitHub The algorithm of the professor used by 23and me and others Central Dogma of DNA of biology The Three-Body Problem AlphaFold Gitpod Foldit Go library for Huggingface SurrealDB Booth’s Least Rotation Go Implementation and wiki Something missing or broken? PRs welcome!

15 years ago, Gerhard discovered magic in the form of Ruby on Rails. It was intuitive and it just worked. That is the context in which Gerhard fell in love with infrastructure and operations. Today, for special episode 77, we start at Seven Shipping Principles, and, in the true spirit of Ship It, we’ll see what happens next. Our guest is David Heinemeier Hansson, creator of Ruby on Rails, co-founder of Basecamp & HEY, and a lot more - check out dhh.dk. Join the discussionChangelog++ members save 5 minutes on this episode because they made the ads disappear. Join today!Sponsors:Sourcegraph – Transform your code into a queryable database to create customizable visual dashboards in seconds. Sourcegraph recently launched Code Insights — now you can track what really matters to you and your team in your codebase. See how other teams are using this awesome feature at about.sourcegraph.com/code-insights Raygun – Never miss another mission-critical issue again — Raygun Alerting is now available for Crash Reporting and Real User Monitoring, to make sure you are quickly notified of the errors, crashes, and front-end performance issues that matter most to you and your business. Set thresholds for your alert based on an increase in error count, a spike in load time, or new issues introduced in the latest deployment. Start your free 14-day trial at Raygun.com Retool – The low-code platform for developers to build internal tools — Some of the best teams out there trust Retool…Brex, Coinbase, Plaid, Doordash, LegalGenius, Amazon, Allbirds, Peloton, and so many more – the developers at these teams trust Retool as the platform to build their internal tools. Try it free at retool.com/changelog Featuring:David Heinemeier Hansson – Twitter, GitHubGerhard Lazu – Mastodon, Twitter, GitHub, WebsiteShow Notes: 📝 Seven Shipping Principles 📝 Why we’re leaving the cloud DHH @ Le Mans 2022 Basecamp Next’s caching hardware - Jan. 2012 - 864GB of RAM - $12k in 2012 Gerhard’s favourite signals from the new 37signals.com Hours aren’t equal Small tech JOMO Email’s new heyday Something missing or broken? PRs welcome!

Recently Chris and Daniel briefly discussed the Open RAIL-M licensing and model releases on Hugging Face. In this episode, Daniel follows up on this topic based on some recent practical experience. Also included is a discussion about graph neural networks, message passing, and tweaking synthesized voices! Join the discussionChangelog++ members support our work, get closer to the metal, and make the ads disappear. Join today!Featuring:Chris Benson – Twitter, GitHub, LinkedIn, WebsiteDaniel Whitenack – Twitter, GitHub, WebsiteShow Notes: Daniel’s team license from recent work Graph Neural Network courses from Zak Jost Coqui voice studio Something missing or broken? PRs welcome!

This week we’re doing some Linux mythbusting and talking retro gaming with Jay LaCroix from Learn Linux TV. This is a preview of what’s to come from our trip to All Things Open next week. By the way, make sure you come and check us out at booth 60. We’ll be recording podcasts, shaking hands, giving out t-shirts and stickers…and speaking of gaming, you can go head-to-head with us on Mario Kart or Rocket League on the Nintendo Switch. We’re giving that Switch away to a lucky winner at the conference, but you have to play to win. If you’re there, make sure you come see us because we want to see you. Join the discussionChangelog++ members get a bonus 8 minutes at the end of this episode and zero ads. Join today!Sponsors:Sentry – Working code means happy customers. That’s exactly why teams choose Sentry. From error tracking to performance monitoring, Sentry helps teams see what actually matters, resolve problems quicker, and learn continuously about their applications - from the frontend to the backend. Use the code CHANGELOG and get the team plan free for three months. InfluxData - InfluxDays 2022 – InfluxDays is back — this is a two-day developer conference from our friends at InfluxData dedicated to building IoT, analytics, and cloud applications with InfluxDB. It’s happening on Nov 2nd and 3rd - learn more and register at influxdays.com Sourcegraph – Transform your code into a queryable database to create customizable visual dashboards in seconds. Sourcegraph recently launched Code Insights — now you can track what really matters to you and your team in your codebase. See how other teams are using this awesome feature at about.sourcegraph.com/code-insights Fly.io – Deploy your apps and databases close to your users. In minutes you can run your Ruby, Go, Node, Deno, Python, or Elixir app (and databases!) all over the world. No ops required. Learn more at fly.io/changelog and check out the speedrun in their docs. Featuring:Jay LaCroix – Twitter, LinkedInAdam Stacoviak – Mastodon, Twitter, GitHub, LinkedIn, WebsiteJerod Santo – Mastodon, Twitter, GitHub, LinkedInShow Notes: Learn Linux TV RetroPie The Homelab Show All Things Open 2022 Something missing or broken? PRs welcome!

Nick & Amelia welcome the co-authors of Tiny CSS Projects to discuss their awesome new (and still in-progress) Manning book all about CSS! Use code podjsparty20 when checking out to save 40% (good for all products in all formats!) and join the JS Party community chat for a chance to win a free ebook copy! Join the discussionChangelog++ members save 5 minutes on this episode because they made the ads disappear. Join today!Sponsors:Square – Develop on the platform that sellers trust. There is a massive opportunity for developers to support Square sellers by building apps for today’s business needs. Learn more at changelog.com/square to dive into the docs, APIs, SDKs and to create your Square Developer account — tell them Changelog sent you. Sentry – Working code means happy customers. That’s exactly why teams choose Sentry. From error tracking to performance monitoring, Sentry helps teams see what actually matters, resolve problems quicker, and learn continuously about their applications - from the frontend to the backend. Use the code CHANGELOG and get the team plan free for three months. Fly.io – Deploy your apps and databases close to your users. In minutes you can run your Ruby, Go, Node, Deno, Python, or Elixir app (and databases!) all over the world. No ops required. Learn more at fly.io/changelog and check out the speedrun in their docs. Featuring:Martine Dowden – Twitter, GitHub, WebsiteMichael Gearon – Nick Nisi – Mastodon, Twitter, GitHub, WebsiteAmelia Wattenberger – Twitter, GitHub, WebsiteShow Notes: Tiny CSS Projects (use code podjsparty20 to save 40%!) Join the JS Party community to win a free ebook! Something missing or broken? PRs welcome!

Mat Ryer gathers a gang of ghouls and ghosts to tell spooky developer stories! Join us to hear tales of Mat’s $1k nightmare, Dee’s infinite loop of horror, Natalie’s haunted time as a junior dev & many, many more. Join the discussionChangelog++ members save 4 minutes on this episode because they made the ads disappear. Join today!Sponsors:Sourcegraph – Transform your code into a queryable database to create customizable visual dashboards in seconds. Sourcegraph recently launched Code Insights — now you can track what really matters to you and your team in your codebase. See how other teams are using this awesome feature at about.sourcegraph.com/code-insights FireHydrant – The reliability platform for every developer. Incidents impact everyone, not just SREs. FireHydrant gives teams the tools to maintain service catalogs, respond to incidents, communicate through status pages, and learn with retrospectives. Small teams up to 10 people can get started for free with all FireHydrant features included. No credit card required to sign up. Learn more at firehydrant.com/ Featuring:Dee Kitchen – TwitterMat Ryer – Twitter, GitHub, LinkedIn, WebsiteKris Brandow – Twitter, GitHubNatalie Pistunovich – Twitter, GitHubJohnny Boursiquot – Twitter, GitHub, WebsiteShow Notes: bluemonday “All About Regular Expressions” by Jade Allen Something missing or broken? PRs welcome!

In today’s episode, we talk about distroless, ko, apko, melange, musl and glibc. The context is Wolfi OS, a community Linux OS designed for the container and cloud-native era. If you are looking for the lightest possible container base image with 0 CVEs and both glibc and musl support, Wolfi OS & the related chainguard-images are worth checking out. Ariadne Conill is an Alpine Linux TSC member & Software Engineer at Chainguard. Join the discussionChangelog++ members save 5 minutes on this episode because they made the ads disappear. Join today!Sponsors:Sentry – Working code means happy customers. That’s exactly why teams choose Sentry. From error tracking to performance monitoring, Sentry helps teams see what actually matters, resolve problems quicker, and learn continuously about their applications - from the frontend to the backend. Use the code CHANGELOG and get the team plan free for three months. FireHydrant – The reliability platform for every developer. Incidents impact everyone, not just SREs. FireHydrant gives teams the tools to maintain service catalogs, respond to incidents, communicate through status pages, and learn with retrospectives. Small teams up to 10 people can get started for free with all FireHydrant features included. No credit card required to sign up. Learn more at firehydrant.com/ Sourcegraph – Transform your code into a queryable database to create customizable visual dashboards in seconds. Sourcegraph recently launched Code Insights — now you can track what really matters to you and your team in your codebase. See how other teams are using this awesome feature at about.sourcegraph.com/code-insights Featuring:Ariadne Conill – Twitter, GitHub, LinkedIn, WebsiteGerhard Lazu – Mastodon, Twitter, GitHub, WebsiteShow Notes: Ariadne’s Twitter thread that kick-started this episode Wolfi OS - a stripped-down distro designed for the cloud-native era Minimal Container images from Chainguard ko - build and deploy Go applications on Kubernetes apko Overview - build OCI images using APK directly melange - build APKs from source code musl libc glibc - GNU C library “We discovered a bug in our repository management service” Something missing or broken? PRs welcome!

This panel discussion was recorded at a recent event hosted by a company, Aryballe, that we previously featured on the podcast (#120). We got a chance to discuss the AI-driven technology transforming the order/fragrance industries, and we went down the rabbit hole discussing how this technology is being adopted at large, well-established companies. Join the discussionChangelog++ members support our work, get closer to the metal, and make the ads disappear. Join today!Featuring:Mary Fischer-Mullins – LinkedInYanis Caritu – LinkedInDaniel Whitenack – Twitter, GitHub, WebsiteShow Notes: Aryballe Cox Automotive Previous episode with Aryballe Something missing or broken? PRs welcome!

Valerian Saliou’s Sonic search backend, Brandon Willett on how to build software like an SRE, DHH on why they’re leaving the cloud, Amos’ HTTP crash course nobody asked for & Sam Magura tells why he and the Spot team are breaking up with CSS-in-JS. View the newsletterJoin the discussionChangelog++ members support our work, get closer to the metal, and make the ads disappear. Join today!Featuring:Jerod Santo – Mastodon, Twitter, GitHub, LinkedIn

This week we’re talking with Will McGugan about using the terminal to not just build software, but also to deliver software. Will is a few months into his journey of building Textualize, a company he started around his open source projects Textual and Rich. When combined Textual and Rich give you a Python framework to build beautiful full-featured TUIs for the Terminal. We talk with Will about his big idea of the terminal as a platform, how he got here from first principles, what it takes to build Textual apps and whether or not they can replace not so good web admins, building, launching, and distributing Textual apps, why Python was his choiice of language, the big picture and business model behind Textualize, and why he’s building this as open source and in public. Join the discussionChangelog++ members save 5 minutes on this episode because they made the ads disappear. Join today!Sponsors:Square – Develop on the platform that sellers trust. There is a massive opportunity for developers to support Square sellers by building apps for today’s business needs. Learn more at changelog.com/square to dive into the docs, APIs, SDKs and to create your Square Developer account — tell them Changelog sent you. FireHydrant – The reliability platform for every developer. Incidents impact everyone, not just SREs. FireHydrant gives teams the tools to maintain service catalogs, respond to incidents, communicate through status pages, and learn with retrospectives. Small teams up to 10 people can get started for free with all FireHydrant features included. No credit card required to sign up. Learn more at firehydrant.com/ Sourcegraph – Transform your code into a queryable database to create customizable visual dashboards in seconds. Sourcegraph recently launched Code Insights — now you can track what really matters to you and your team in your codebase. See how other teams are using this awesome feature at about.sourcegraph.com/code-insights Fastly – Our bandwidth partner. Fastly powers fast, secure, and scalable digital experiences. Move beyond your content delivery network to their powerful edge cloud platform. Learn more at fastly.com Featuring:Will McGugan – Twitter, GitHubAdam Stacoviak – Mastodon, Twitter, GitHub, LinkedIn, WebsiteJerod Santo – Mastodon, Twitter, GitHub, LinkedInShow Notes: Textualize.io Textualize is Hiring! Textualize/textual Projects using Textual Textualize/rich Projects using Rich Something missing or broken? PRs welcome!