Trevor Noah and his friends discuss the significance of turning 40, reinventing oneself, leaving The Daily Show, Rachel Dolezal's OnlyFans debut, and OpenAI's Sora launch. They explore changes in friendships, parenting, celebrating milestones, and the future implications of AI technology on personal fulfillment and societal views.

Bryan Johnson, a tech entrepreneur, discusses his efforts to live longer and reverse aging. Topics include extreme anti-aging regimens, achieving 'perfect sleep,' and making lifestyle changes for longevity.

Trevor and friends discuss the Grammys, including handling Meryl Streep and Taylor Swift’s late arrivals, Jay-Z’s speech, and navigating music’s biggest night. They also explore breast milk for bodybuilders, the selection process and controversies of the Grammy Awards, dissatisfaction in the face of success, cultural greetings, and controversy surrounding the rap album category at the Grammys.

Trevor Noah interviews Quinta Brunson, creator of Abbott Elementary. They discuss her Philly comedy roots, inspiration from Spike Lee and Apple's Photo Booth, and the impact of everyday concerns on politics.

Trevor Noah sits down with comedy superstar Kevin Hart to discuss life as professional comedians, the challenges of large venues versus theaters, rising up the ranks, and whether Kevin really has the body of a swimmer.

Mark Cuban, entrepreneur and television personality, joins Trevor Noah to discuss his recent life changes, including selling his majority stake in the Dallas Mavericks and leaving Shark Tank. They also talk about his Twitter battle with Elon Musk and his plans to shake up the American healthcare system by selling generic drugs at cheaper prices through transparency.

Trevor Noah chats with tennis champion Nick Kyrgios about his 'bad boy' reputation, challenges in tennis, kindred spirit Naomi Osaka, gaming, and his new OnlyFans account.

Trevor and his friends discuss Jeffrey Epstein's 'list,' Harvard's president resignation, and hopes and worries for 2024. They also explore conspiracy theories, manipulative tactics of Harvey Weinstein and Epstein, and the complexity of life's issues. Additionally, they touch on self-regulation on social media and share hopeful reflections for the future.

Los Angeles mayor Karen Bass discusses her work as a high school student on Bobby Kennedy’s campaign, LA's homeless crisis, and whether she'd ever run for President.

Tech ethicist and entrepreneur Tristan Harris joins Trevor Noah to discuss AI skepticism, the dangers of scaling AI models, and the influence of AI and social media incentives. They explore the impact of social media on addiction, polarization, truth, and democracy. They also address the need for creating a shared reality on social media platforms and the importance of responsible governance and regulation to prevent misuse of powerful technologies.