ID:IOTS - Infectious Disease Insight Of Two Specialists

In this episode, the ID:IOTS Podcast Microbiome Correspondent Dr Anastasia "Tash" Theodosiou, returns to talk about her favourite subject! This episode is part 1 of 2. Here we discuss: - What is the microbiome- Viewing the microbiome as an organ system- The microbiome's association with disease- How we study the microbiomeStay tuned for part 2 (in 1-2 weeks depending on editing), when we talk about the effect of medicine on the microbiome, microbiotoxicity, and what you can do to keep your patients' microbiomes in tip top shape! https://www.researchgate.net/profile/Anastasia-Theodosiouhttps://x.com/doctoranastasia Register for the BIA Autumn Trainees Meeting here!  Support the showQuestions, comments, suggestions to idiotspodcasting@gmail.com or on Bluesky @idiots-pod.bsky.socialPrep notes for completed episodes can be found here (Not all episodes have prep notes).If you are enjoying the podcast please leave a review on your preferred podcast app!Feel like giving back? Donations of caffeine gratefully received!https://www.buymeacoffee.com/idiotspod

Join us for this special 80th episode celebrating Jame's favourite trial.https://www.nejm.org/doi/full/10.1056/NEJMoa1808312Prep notes (including the images referred to in the poem) here. Special thanks to the Wikiguidelines Endocarditis crew for their work summarising the evidence this poem was based on. Support the showQuestions, comments, suggestions to idiotspodcasting@gmail.com or on Bluesky @idiots-pod.bsky.socialPrep notes for completed episodes can be found here (Not all episodes have prep notes).If you are enjoying the podcast please leave a review on your preferred podcast app!Feel like giving back? Donations of caffeine gratefully received!https://www.buymeacoffee.com/idiotspod

Presenting: More on Penicillin-Binding-Proteins than you realistically ever need to know! What is the difference between Gram positive and negative bacteria's cell walls?What is a Penicillin Binding Protein (PBP)?Why are they called PBPs?What do PBPs do?What makes MRSA resistant to (most) beta-lactams?These any many more questions answered!Notion page here - you'll need it for this one, check it out!  Register for the BIA Autumn Trainees Meeting here!  Support the showQuestions, comments, suggestions to idiotspodcasting@gmail.com or on Bluesky @idiots-pod.bsky.socialPrep notes for completed episodes can be found here (Not all episodes have prep notes).If you are enjoying the podcast please leave a review on your preferred podcast app!Feel like giving back? Donations of caffeine gratefully received!https://www.buymeacoffee.com/idiotspod

One PK table to rule them allOne table to find themOne table to bring them all And in the darkness blind them… …with awesome antibiotic PK facts you can use to bedazzle your friends and enemies alike! Prep notes here.  Register for the BIA Autumn Trainees Meeting here!  Support the showQuestions, comments, suggestions to idiotspodcasting@gmail.com or on Bluesky @idiots-pod.bsky.socialPrep notes for completed episodes can be found here (Not all episodes have prep notes).If you are enjoying the podcast please leave a review on your preferred podcast app!Feel like giving back? Donations of caffeine gratefully received!https://www.buymeacoffee.com/idiotspod

The last Pharmacokinetics episode had finally been …Excreted!  This episode  covers the ‘drug out’ bit of pharmacokinetics, including things such as:  -What is clearance? -how to calculate half life and -doesn’t everything leave through the kidneys anyway? (That is sort of true, also shut up).  Check out our prep notes (including for this episode) here.  Register for the BIA Autumn Trainees Meeting here!  Support the showQuestions, comments, suggestions to idiotspodcasting@gmail.com or on Bluesky @idiots-pod.bsky.socialPrep notes for completed episodes can be found here (Not all episodes have prep notes).If you are enjoying the podcast please leave a review on your preferred podcast app!Feel like giving back? Donations of caffeine gratefully received!https://www.buymeacoffee.com/idiotspod

Explore the complexities of drug distribution in pharmacokinetics, focusing on antibiotics like Amoxicillin and CallumShutUpicillin. Discuss the volume of distribution and plasma protein binding of antimicrobials. Delve into how low albumin levels impact drug efficacy in intensive care. Learn how molecular size and volume distribution influence antibiotic movement and clearance rates for effective treatment.

Exploring the importance of bioavailability in antibiotics for effective treatment. Factors in choosing the right antibiotic, drug absorption in the gastrointestinal tract, and the significance of bioavailability. Contrasting oral and IV antibiotic administration routes, and optimizing administration for better stewardship and patient care.

In this final episode of the Nobbling the Nonfermentors mini-series, Jame and Callum discuss the (mostly historical) pathogen Burkholderia mallei, causative agent of Glanders. We did it. We got to the end. Nonfermentors... Nobbled.  Register for the BIA Autumn Trainees Meeting here!  Support the showQuestions, comments, suggestions to idiotspodcasting@gmail.com or on Bluesky @idiots-pod.bsky.socialPrep notes for completed episodes can be found here (Not all episodes have prep notes).If you are enjoying the podcast please leave a review on your preferred podcast app!Feel like giving back? Donations of caffeine gratefully received!https://www.buymeacoffee.com/idiotspod

Post-publication, Callum and Jame give a little extra information on the SABATO trial in its final form compared to it's pre-publication state. Final article here:Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial, Kaasch, Achim J Valiente, Adoración et al. Lancet Infect Dis. 2024 Jan 17:S1473-3099(23)00756-9.PMID: 38244557.https://doi.org/10.1016/S1473-3099(23)00756-9 Support the showQuestions, comments, suggestions to idiotspodcasting@gmail.com or on Bluesky @idiots-pod.bsky.socialPrep notes for completed episodes can be found here (Not all episodes have prep notes).If you are enjoying the podcast please leave a review on your preferred podcast app!Feel like giving back? Donations of caffeine gratefully received!https://www.buymeacoffee.com/idiotspod

JOURNAL CLUB, YO, IT’S A SABATO!!!Join Jame and Callum as we travel back in time to when we recorded this deep dive into the SABATO trial pre-print, now peer-reviewed and published in the Lancet ID!In the next episode we'll give a little update as to how the final article differs from the preprint (not much). We also talked about in our FIS Highlights Episode 3. We loved this trial and we hope you’ll all give it a read, it’s well worth it! Article here:Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial, Kaasch, Achim J Valiente, Adoración et al. Lancet Infect Dis. 2024 Jan 17:S1473-3099(23)00756-9. PMID: 38244557.https://doi.org/10.1016/S1473-3099(23)00756-9 Register for the BIA Autumn Trainees Meeting here!  Support the showQuestions, comments, suggestions to idiotspodcasting@gmail.com or on Bluesky @idiots-pod.bsky.socialPrep notes for completed episodes can be found here (Not all episodes have prep notes).If you are enjoying the podcast please leave a review on your preferred podcast app!Feel like giving back? Donations of caffeine gratefully received!https://www.buymeacoffee.com/idiotspod