Dev and Doc: AI For Healthcare Podcast

AI agents are here, but how did we get here in the first place? How do we build and leverage AI agents for high stakes domains like healthcare? In this episode of Dev and Doc, we go deep into the forest that is AI agents and computer control - starting from the "caveman" era of LLMs discovering tools, to cultivating intelligent models and agentic workflows. We dissect everyday agents like MANUS AI, and deep dive into how, where and when AI agents should be used. Are these agents hype or hope, is this actually the second deepseek moment?👋 Hey! If you are enjoying our conversations, reach out, share your thoughts and journey with us. Don't forget to subscribe whilst you're here :)Episode Timestamps:00:00 Highlight3:13 start / intro5:20 LLM's caveman era - tool usage6:46 Agents have autonomy and interact with environment11:15 workflows and agentic flows15:30 when should you be using an agent?24:27 vibe coding is like driving a car29:07 Demo - MANUS gathering financial trends, computer control35:55 Demo MANUS AI- website creation for Autism Assessment49:05 computer control factions- Freedom vs Process automation55:00 Autism website testing59:13 summary + endHosts:👨🏻‍⚕️Doc - Dr. Joshua Au Yeung - https://www.linkedin.com/in/dr-joshua-auyeung/🤖Dev - Zeljko Kraljevic https://twitter.com/zeljkokrFind us on:YT - https://youtube.com/@DevAndDocSpotify - https://podcasters.spotify.com/pod/show/devanddocApple- https://podcasts.apple.com/gb/podcast/dev-and-doc-ai-for-healthcare-podcast/id1751495120Substack- https://aiforhealthcare.substack.com/For enquiries:📧Devanddoc@gmail.comCredits:🎞️ Editor- Dragan Kraljević https://www.instagram.com/dragan_kraljevic/🎨Brand design and art direction - Ana Grigorovici https://www.behance.net/anagrigorovici027d

Can Claude perform a range of complex clinical tasks? Dev and Doc are here to investigate.Claude sonnet 3.7 was released less than 48 hours ago, the model is highly intelligent and is one of the best we have seen in recent memory. Definitely passes the vibe check.We give some amazing examples of coding with claude with few shot prompts, and cover technical and clinical evaluations and share our first thoughts. We even tested claude to take a patient history!NB - PLEASE don't do this at home, obviously this is a demo and we do not in any way condone or recommend using an LLM as your doctor or healthcare provider, we are just demonstrating what the future could be. If you are sick, please seek a medical professional.👋 Hey! If you are enjoying our conversations, reach out, share your thoughts and journey with us. Don't forget to subscribe whilst you're here :)TIMESTAMPS00:00 start + highlights01:54 Introduction08:54 Benchmarks, state of the art14:44 guardrails, refusals, AI safety and catastrophic risks22:36 show and tell- great for coding and make video games!26:54 example hospital runner30:17 Medical use cases- clinical coding, biomedical entity extraction37:04 only medical example in Claude model card- still hallucinating citations38:37 making an anatomy app40:10 forecasting clinical diagnoses43:36 taking a medical history from a patient53:33 wrap up👨🏻‍⚕️Doc - Dr. Joshua Au Yeung - linkedin.com/in/dr-joshua-auyeung🤖Dev - Zeljko Kraljevic twitter.com/zeljkokrYT:youtube.com/@DevAndDocSpotify:podcasters.spotify.com/pod/show/devanddocApple:podcasts.apple.com/gb/podcast/dev-and-doc-ai-for-healthcare-podcast/id1751495120Substack:aiforhealthcare.substack.comFor enquiries - 📧 Devanddoc@gmail.com🎞️ Editor - Dragan Kraljević instagram.com/dragan_kraljevic🎨 Brand design - Ana Grigorovici behance.net/anagrigorovici027d

Is it still worth doing a PhD in 2025? Is the academic system broken in this publish-or-perish landscape? When is a PhD not worth pursuing? About this Episode In this Dev and Doc episode, Zeljko (now associate professor!) and Josh (doctor, PhD drop out) talk about the good and the bad of PhD life. They provide insight into the academic world with a focus on computer science and machine learning. 👋 Connect With Us! Hey! If you are enjoying our conversations, reach out, share your thoughts and journey with us. Don't forget to subscribe whilst you're here :) 🎙️ Hosts 👨🏻‍⚕️ Doc - Dr. Joshua Au Yeung - LinkedIn 🤖 Dev - Zeljko Kraljevic - Twitter ⏳ Timestamps 00:00 - Start and highlight 01:42 - Intro 03:11 - What made you pursue PhD in the first place 05:05 - Industry or PhD first 10:00 - Positives - Moonshots 17:03 - Positives - Access to world experts and collaboration 20:55 - Positives - Open source and open science 24:49 - Positives - A good environment enables a smooth PhD 27:04 - Negatives - You are a one-man show 31:33 - Negatives - Publish or Perish 45:44 - Bring your research closer to the audience through blogs and other media, journals are legacy media 51:20 - Verdict - Is a PhD still worth it in 2025? 📢 Follow Us LinkedIn Newsletter YouTube Spotify Apple Podcasts Substack 📧 Contact Us For enquiries - devanddoc@gmail.com 🎞️ Video Production 🎬 Editor - Dragan Kraljević - Instagram 🎨 Brand Design & Art Direction - Ana Grigorovici - Behance

Dev and Doc put Deepseek R1 to the test in a technical and clinical deep dive. 👋 Hey! If you are enjoying our conversations, reach out, share your thoughts and journey with us. Don't forget to subscribe whilst you're here :) 👨🏻‍⚕️Doc - Dr. Joshua Au Yeung - https://www.linkedin.com/in/dr-joshua-au-yeung/ 🤖Dev - Zeljko Kraljevic https://twitter.com/zeljkokr TIMESTAMPS 00:00 Highlights 04:36 Intro 08:29 response from OpenAI, Anthropic- model training costs, tightening restrictions on China, pricing wars 13:13 what an open-source deepseek means for the world. 15:38 Sam altman and Dario amodei feeling the pressure 23:10 TECHNICAL deep dive - RLHF, ppo, dpo 37:08 GRPO, R1s secret sauce 45:02 the aha moment, learning like a human? 50:25 deepseek R1 training and controversy 59:08 deepseek healthcare evaluation - Ethnic Bias 1:06:17 The diagnostic acid test (fail) 1:12:46 Coding clinical data / Medical billing (shout out SNOMED) LinkedIn Newsletter https://www.linkedin.com/build-relation/newsletter-follow?entityUrn=7216474068085026817 YT - https://youtube.com/@DevAndDoc Spotify - https://podcasters.spotify.com/pod/show/devanddoc Apple- https://podcasts.apple.com/gb/podcast/dev-and-doc-ai-for-healthcare-podcast/id1751495120 Substack- https://aiforhealthcare.substack.com/ For enquiries - 📧Devanddoc@gmail.com 🎞️ Editor- Dragan Kraljević https://www.instagram.com/dragan_kraljevic/ 🎨Brand design and art direction - Ana Grigorovici https://www.behance.net/anagrigorovici027d

Dev and Doc - Latest News Dev and Doc - Latest News It's 2025, Dev and Doc cover the latest news including Google's deep research and notebook LM, DeepMind's Promptbreeder, and Anthropic's new RAG approach. We also go through what retrieval augmented generation (RAG) is, and how this technique is advancing LLM performance. 👋 Hey! If you are enjoying our conversations, reach out, share your thoughts and journey with us. Don't forget to subscribe whilst you're here :) Meet the Team 👨🏻‍⚕️ Doc - Dr. Joshua Au Yeung - LinkedIn 🤖 Dev - Zeljko Kraljevic - Twitter Where to Follow Us LinkedIn Newsletter YouTube Spotify Apple Podcasts Substack Contact Us 📧 For enquiries - Devanddoc@gmail.com Credits 🎞️ Editor - Dragan Kraljević - Instagram 🎨 Brand Design and Art Direction - Ana Grigorovici - Behance Episode Timeline 00:00 Highlights 00:53 News - Notebook LM, OpenAI 12 days of Christmas 07:44 Change in the meta - post-training 11:34 Optimizing prompts with DeepMind Promptbreeder 13:20 Is OpenAI losing their lead against Google 16:45 Deep research vs Perplexity 24:18 AIME and oncology 26:00 Deep research results 30:20 RAG intro 33:14 Second pass RAG 36:20 RAG didn't take off 38:40 Wikichat 39:16 How do we improve on RAG? 41:11 Semantic/topic chunking, cross-encoders, agentic RAG 51:15 Google’s Problem Decomposition 53:32 Anthropic’s Contextual Retrieval Processing 56:07 Summary and wrap up References Cross Encoders Wikichat Google's Problem Decomposition Anthropic's Contextual Retrieval Google AIME in Oncology DeepMind's Promptbreeder

The discussion kicks off with the intriguing features of OpenAI's GPT-01 and its ability to tackle complex medical issues like diabetes. They dive into how AI models reason through challenges with a Tetris-like game, highlighting the hurdles of image processing. Evaluations showcase GPT-01's strengths and weaknesses in healthcare diagnostics, prompting a critical look at AI's reliability. The conversation also tackles the tricky world of opioid dose conversions and the importance of accuracy in medical coding, revealing a fascinating intersection of AI and healthcare.

Dev and Doc is joined by guest Annabelle Painter, doctor, CMO, and podcaster for the Royal Society of Medicine Digital Health Podcast. We deep dive into explainability and interpretability with concrete healthcare examples. Check out Dr. Painter's Podcast here, she has some amazing guests and great insights into AI in healthcare! - https://spotify.link/pzSgxmpD5yb 👋 Hey! If you are enjoying our conversations, reach out, share your thoughts and journey with us. Don't forget to subscribe whilst you're here :) 👨🏻‍⚕️ Doc - Dr. Joshua Au Yeung - https://www.linkedin.com/in/dr-joshua-auyeung/ 🤖 Dev - Zeljko Kraljevic - https://twitter.com/zeljkokr LinkedIn Newsletter YouTube Channel Spotify Apple Podcasts Substack For enquiries - 📧 Devanddoc@gmail.com 🎞️ Editor - Dragan Kraljević - https://www.instagram.com/dragan_kraljevic/ 🎨 Brand design and art direction - Ana Grigorovici - https://www.behance.net/anagrigorovici027d Timestamps: 00:00 - Start + highlights 03:47 - Intro 08:16 - Does all AI in healthcare need to be explainable? 15:56 - History and explanation of Explainable/Interpretable AI 20:43 - Gradient-based saliency and heat maps 24:14 - LIME - Local Interpretable Model-agnostic Explanations 30:09 - Nonsensical correlations - When explainability goes wrong 33:57 - Modern explainability - Anthropic 37:15 - Comparing LLMs with the human brain 40:02 - Clinician-AI interaction 47:11 - Where is this all going? Aligning models to ground truth and teaching them to say "I don't know" References: Fun Examples of when models go wrong - Nonsensical correlations Mechanistic interpretability Anthropic - Mapping the mind of language models Limitations of current AI explainability approaches Explainability does not improve automation bias in radiologists

An explainer on Foundation models for pathology, from Microsoft's Gigapath to Owkin's H-optimus-0, every company, big or small, are building pathology AI models. In this episode, Doc talks to Sean M. Hacking, assistant professor in Pathology at NYU Grossman School of Medicine and Özgür Şahin, particle physicist at CERN. Together they are building the infrastructure for digital pathology that then allows training of pathology foundational models. Find out more at https://www.pathonn.com/. 👋 Hey! If you are enjoying our conversations, reach out, share your thoughts and journey with us. Don't forget to subscribe whilst you're here :) https://www.linkedin.com/build-relation/newsletter-follow?entityUrn=7216474068085026817 https://youtube.com/@DevAndDoc https://podcasters.spotify.com/pod/show/devanddoc https://podcasts.apple.com/gb/podcast/dev-and-doc-ai-for-healthcare-podcast/id1751495120 https://aiforhealthcare.substack.com/ 👨🏻‍⚕️Doc - https://www.linkedin.com/in/dr-joshua-auyeung/ 🤖Dev - https://twitter.com/zeljkokr 🎞️ Editor - https://www.instagram.com/dragan_kraljevic/ 🎨 Brand design and art direction - https://www.behance.net/anagrigorovici027d 00:00 Introduction 03:28 Why pathology 06:42 Transporting slides is a logistical nightmare 13:20 When particle physics and AI pathology collide 17:55 AI digital pathology - Patch-based architecture and sparse topologies 27:09 Is there enough pathology data? 29:11 Microsoft and Gigapath, transformer models for pathology 33:55 Pathology models clinical applications 43:18 Staining applications of AI 49:22 Building a digital pathology startup - Patho-NN 57:36 Using AI to see tumor grading features that humans can’t see References: https://www.nature.com/articles/s41586-024-07441-w https://www.microsoft.com/en-us/research/blog/gigapath-whole-slide-foundation-model-for-digital-pathology/ https://www.nature.com/articles/s41379-021-00919-2

Doc talks to Dr Derrick Khor - Cancer Doctor, HealthTech Consultant and Linkedin Guru. We share Derrick's insights from consulting over 120 companies and a step-by-step guide on how to build a successful Healthcare company. You can find more of Derrick and his helpful guides - https://adoptadoc.com/resources/ profile- https://www.linkedin.com/in/derrick-khor/ 👋 Hey! If you are enjoying our conversations, reach out, share your thoughts and journey with us. Don't forget to subscribe whilst you're here :) Dev&Doc is a podcast where doctors and developers deep dive into the potential of AI in healthcare. 👨🏻‍⚕️Doc - Dr. Joshua Au Yeung 🤖Dev - Zeljko KraljevicLinkedIn NewsletterYouTubeSpotifyAppleSubstack For enquiries - 📧 Devanddoc@gmail.com <p>🎞️ Editor - <a href="https://www.instagram.com/dragan_kraljevic/">Dragan Kraljević</a></p> <p>🎨 Brand design and art direction - <a href="https://www.behance.net/anagrigorovici027d">Ana Grigorovici</a></p> Timestamps 00:00 Highlights and intro 3:01 Start 5:10 getting into health tech 8:03 lack of clinicians in start ups 15:07 Derrick's own healthtech journey to consulting 23:37 Start ups and failure 27:35 the start up road map 32:16 are you a medical device (samd)? Intended use 40:55 clinical evidence generation 48:16 go to market, NHS DTAC 57:57 power of networking, social media, linkedin 1:02:43 top UK health tech companies to look out for

Dev and Doc deconstruct digital biomarkers! This is a fascinating and nascent field in the world of medicine, how have biomarkers transformed the way we practice medicine, and how will AI and wearables, sensors and digital fingerprints transform the way we practice in the future? Hey! If you are enjoying our conversations, reach out, share your thoughts and journey with us. Don't forget to subscribe whilst you're here :) find us on youtube- @Dev and Doc 📙Substack: https://aiforhealthcare.substack.com/👨🏻‍⚕️Doc - Dr. Joshua Au Yeung - https://www.linkedin.com/in/dr-joshua-auyeung/🤖Dev - Zeljko Kraljevic https://twitter.com/zeljkokr🎞️ Editor- Dragan Kraljević https://www.instagram.com/dragan_kraljevic/🎨Brand design and art direction - Ana Grigorovici https://www.behance.net/anagrigorovici027d Timestamp 00:00 highlights 01:50 intro 02:40 how biomarkers evolved in the last century 6:02 what is the definition of a biomarker 10:00 biomarkers can be very biased depending on who you are testing 12:31 when does a test become a biomarker 17:30 the digital age and measurements - AI vision in retina scans, digital stethoscopes 23:50 what is an “analog” biomarker vs digital biomarker? 30:10 where do biomarkers fail in evidence based medicine? 34:55 Biomarkers are pretty poor for mental health 47:57 can AI predict depression better than humans? 51:21 Digital biomarkers to detect movement disorders 01:00:04 this can change clinical trials forever Refs - variable definitions of biomarkers https://informatics.bmj.com/content/31/1/e100914 -digital biomarkers convergence nature paper https://www.nature.com/articles/s41746-022-00583-z -digital stethoscope for heart failure https://www.thelancet.com/pdfs/journals/landig/PIIS2589-7500(21)00256-9.pdf -touch screen typing depression paper https://www.nature.com/articles/s41746-022-00583-z - Duchennes body suit biomarker https://www.nature.com/articles/s41591-022-02045-1#Sec9 - Friedreichs ataxia body suit https://www.nature.com/articles/s41591-022-02159-6?fromPaywallRec=false#Sec9