ACCEL Lite: Featured ACCEL Interviews on Exciting CV Research

The most common congenital heart defect, congenital BAV, affects 1% of the population (2% in men, 0.5% in women), with a male-to-female ratio of 2:1 to 3:1. It's characterized by diverse phenotypic expressions and outcomes, falling into two prognostic groups: Typical valvulo-aortopathy: Most common, with progressive BAV dysfunction and/or aorta dilatation but long-term survival similar to the general population. Complex valvulo-aortopathy: Associated with significant concomitant disorders and/or accelerated valvulo-aortopathy, leading to inferior long-term survival. BAV is a lifelong clinical condition with a morbidity burden exceeding 80%. Common complications include progression to ≥ moderate AS or AR, native aortic valve surgery, aortic aneurysm, surgery for aortic aneurysm, surgery for coarctation of the aorta, infective endocarditis, and aortic dissection. In this interview, Hector I. Michelena, MD, FACC and W. Douglas Weaver MD, MACC discuss the history of and complications associated with bicuspid valvuloaortopathy. Subscribe on Apple Podcasts | Subscribe on Google Play | Subscribe to ACCEL

Discover how detection of coronary artery calcium can greatly enhance risk prediction and risk mitigation, making it a critical tool for clinicians aiming to personalize patient care and prevent future cardiac events. In this interview, Michael D. Shapiro, DO, FACC and Roger S. Blumenthal MD, FACC explore CAC scoring and the role of calcium detection in tailoring patient care, personalized risk assessment, and the prevention of future cardiac events. Subscribe on Apple Podcasts | Subscribe on Google Play | Subscribe to ACCEL

In this interview, Leslie Cho, MD, FACC, and Steven E. Nissen MD, MACC explore the nuances of estrogen and testosterone replacement: who benefits, when to consider it, and how long it should last. Subscribe to ACCEL

Ticagrelor monotherapy following one month of dual antiplatelet therapy (DAPT) outperforms 12-month DAPT (aspirin and ticagrelor) post PCI for reducing clinically meaningful bleeding with no increased thrombotic risk. In this interview, Gregg W Stone MD, FACC and Anthony N. DeMaria MD, MACC discuss principal results from the Ultimate DAPT Trial. Subscribe to ACCEL Lite Other ACC resources on DAPT and bleeding risk: 1. One-Month Ticagrelor Monotherapy After PCI in Acute Coronary Syndromes - IVUS-ACS/ULTIMATE-DAPT 2. Study Suggests Most Patients with Acute Coronary Syndromes Can Safely Stop Aspirin One Month After Percutaneous Coronary Intervention 3. ACC.24 Presentation Slides | ULTIMATE-DAPT

The Be Active trial demonstrates the efficacy of scalable interventions, incorporating remote monitoring and behavioral economics, in boosting physical activity among high-risk cardiovascular patients. Lasting effects were observed even six months post-intervention. While additional data may be warranted for some stakeholders, these interventions hold promise as integral components of exercise-based prevention strategies for cardiovascular disease. In this interview, Alexander Fanaroff, MD, MHS and Glenn A. Hirsch MD, MHS, FACC discuss results from the Be Active RCT. Subscribe on Apple Podcasts |

The podcast discusses the VICTORION-INITIATE study showing superior outcomes with inclisarin for lipid-lowering therapy. Topics include challenges in achieving optimal lipid levels, efficacy of inclisarin versus usual care, and optimizing lipid control with pharmacists.

Cardiologists James Januzzi and Alison Bailey discuss ARISE-HF study results on diabetic cardiomyopathy. They explore the effects of aldose reductase inhibitors in preventing cardiomyopathy in diabetic patients, criteria for participant selection in heart failure trials, selective testing for high-risk subgroups, and the impact of AT-001 on delaying heart failure symptoms.

Cardiologist Jerry Blackwell discusses the future of cardiology, emphasizing value-based care and reducing costs while enhancing patient care. The podcast explores the impact of middlemen on healthcare costs, the evolution of cardiology practice landscape, and the role of private equity. Furthermore, it delves into emerging trends and concerns in cardiology training and professionalism.

Cardiologists Javed Butler and Sun Moon Kim discuss EMPACT-MI trial results on heart failure risk post-myocardial infarction. They explore misconceptions on EF percentages, diuretics, and benefits of SGLT2 inhibitors. Real-world evidence shapes future treatment strategies.

Experts discuss the challenges and advancements in managing heart failure with preserved ejection fraction, including the effectiveness of SGLT2 inhibitors, mineralocorticoid receptor antagonists, and other targeted therapies. They also explore the evolving landscape of device therapy for this population, offering practical guidance for clinicians.