Big Brains

Every year many of us set New Year’s resolutions, and almost none of us actually follow through on them. In a year when fulfilling our goals and resolutions feels more pressing than ever while our motivation may be at its lowest; let’s do what we do best: Turn to the research to get some concrete answers on how to follow through. Ayelet Fishbach is a professor at the University of Chicago Booth School of Business and the author of a new book, Get It Done: Surprising Lessons from The Science of Motivation. She is one of the leading experts on the research behind what keeps us motivated to complete our goals.

Prof. Jacqueline Stewart’s career has examined the histories of overlooked Black filmmakers and Black audiences. Last year, the University of Chicago film scholar Stewart won a prestigious MacArthur fellowship for “illuminating the contributions that overlooked Black filmmakers and communities of spectators have made to cinema’s development as an art form.” Stewart also serves as the host of Silent Sunday Nights on Turner Classic Movies and is chief artistic and programming officer at the Academy Museum of Motion Pictures. On this episode, Stewart explores the history of Black cinema and explains how preservation and archiving are not neutral acts, but contribute to how we contextualize and understand Black history.

The race to cure cancer has been running a long time, but two University of Chicago scientists are working to bring it closer to the finish line. Thinking like engineers rather than doctors, Profs. Jeffery Hubbell and Melody Swartz of the Pritzker School of Molecular Engineering are bringing new approaches to the field of immunotherapy—and helping us rethink cancer research. Swartz has even developed what she calls a cancer ‘vaccine’—a way to train the immune system to recognize cancer cells as bad. By tinkering with the different parts inside our bodies, Swartz’s and Hubbell’s labs are searching for ways to utilize immunotherapy while eliminating its downsides. If their biggest ideas pass clinical trials, we could enter a new era of fighting not only cancer, but a host of other diseases.

There’s something strange happening with violent crime in America. Incidents are reaching levels they haven’t hit in decades, and nobody seems to know why. But, to go even deeper, what causes violent crime to happen at all—and what can be done to help prevent it? Prof. Jens Ludwig is an economist and urban policy expert at the University of Chicago and the Pritzker Director of the Crime Lab, which partners with policymakers in major cities across the country to help reduce gun violence and reduce the harms of the criminal justice system itself. Using randomized control trials and massive data sets, he and his colleagues have been able to find demonstrable policy strategies and community programs for preventing crime.

If you could have any superpower, what would it be? Most people say they’d want to read minds. But Prof. Nicholas Epley of the University of Chicago Booth School of Business says you already have that power: You just need to use it. We took some time off to enjoy the holiday and our families. And, like many of you here in the vaccine phase of the pandemic, we really cherished speaking to and connecting with people in person again. Which reminded us of an episode we did years ago about a simple but powerful idea…that talking to strangers can make you healthier. We want to reshare that episode with you this week, and we’ll be back with a brand new episode next week! Thanks for listening!

If you know anything about black holes, it may come as a surprise to learn that there’s actually one lurking at the center of our galaxy. It was uncovered by UCLA astrophysicist Andrea Ghez, and in 2020 she won a Nobel Prize for this discovery. But how do you go about finding something that emits no light? How do you see the unseeable? In this episode, Ghez explains how she proved this supermassive black hole was hiding in the Milky Way and answers all our pressing questions like, including: Are we being sucked into this monster? And could researching it prove Einstein’s theory of relativity is actually wrong?

Experts say we’re living through a renaissance in genetics research. The Human Genome project has explained our most fundamental genetics, CRISPR gene editing can be used to shape genetic code, and companies like 23 & Me can trace your ancestry from a single saliva swab. But all this new genetic information has people asking: How much do genetics determine our outcomes in life? We all understand that our genes determine our height, hair and eye color, but what about intelligence, educational attainment or financial success? In a new book, The Genetic Lottery: Why DNA Matters for Social Equality, behavior geneticist Kathryn Paige Harden explores these uncomfortable corners of genetics research and explains why our economic and sociopolitical systems need to take it into account.

It feels like our world has never faced so many crisis all at the same time, and trying to solve them at once seems impossible. But, in 2015, the United Nations came together to develop a list of 17 Sustainable Development Goals, a blueprint for addressing all of humanity’s problems—from poverty to climate change to peace and justice. And, amazingly, every UN nation signed it. So, how is it going? On this episode, we talk with Chris Williams, the director of UN Habitat; and Prof. Luis Bettencourt, director of the Mansueto Institute for Urban Innovation at the University of Chicago, to get some insight on how they've been studying and working on these goals, as well as their perspective on the current state of our global crisis moving forward.

There are a lot of problems in our world today, but if our water systems aren’t working, everything else takes a backseat. From a lack of freshwater to droughts on the West Coast to contaminants like PFAS and lead in many of our homes, our water systems are in trouble. But one scientist sees a solution to our making our water system sustainable by using artificial intelligence and machine learning. Junhong Chen is a professor of molecular engineering at the University of Chicago and the lead water strategist at UChicago-affiliated Argonne National Laboratory. He’s using AI to address many of our global water crises in some surprising ways.

Sometimes, the biggest discoveries have to do with the smallest things. In this case, we’re talking nano. Specifically, nanocrystals. World-renowned chemist Paul Alivisatos has changed the field of nanoscience with these tiny crystals, but he’s also found ways to use them to create incredible new technologies in healthcare, energy, and electronic devices. As if that weren’t enough, Paul Alivisatos is also an eminent leader in academia. He was the Executive Vice Chancellor and Provost at the University of California, Berkley and is now the President of the University of Chicago. In that role, he hopes to implement his vision of an “engaged university” to push forward the role of academia in society.