Genetic Breakthrough in Alzheimer's Disease

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Identifying APOE4 homozygosity as a key genetic cause of Alzheimer's disease reveals that individuals with two copies of the APOE4 gene variant have a significantly higher risk of developing the condition. This discovery challenges the previous belief that Alzheimer's arose from various factors, with APOE4 homozygosity being able to directly cause the disease in up to 20% of patients. This breakthrough opens avenues for specialized research, clinical trials, and potential gene therapy treatments. However, it is crucial to acknowledge that APOE4 homozygosity is not the sole genetic factor in Alzheimer's, with rare mutations in other genes like APP, PSEN1, and PSEN2 contributing to early onset Alzheimer's. Recent studies have also uncovered new genetic risk variants, especially in African populations.

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On today's episode of Discover Daily:We explore Microsoft's development of MAI-1, a massive 500 billion parameter AI model aimed at competing with OpenAI's GPT-4 and Google's AI offerings. Led by AI pioneer Mustafa Suleyman after Microsoft acquired his startup Inflection AI, MAI-1 represents a major upgrade to Microsoft's language model capabilities.

Then, we discuss OpenAI's new partnership with Stack Overflow to enhance its models' technical knowledge. By integrating Stack Overflow's data, OpenAI can provide more accurate coding and programming responses, while Stack Overflow builds its own OverflowAI assistant using OpenAI's language models.In a major medical breakthrough, researchers have identified APOE4 homozygosity as a new genetic cause of Alzheimer's disease. This discovery opens up avenues for more targeted research, clinical trials, and potential gene therapies for this subset of Alzheimer's patients.

Shifting gears, we take a look at some of the most iconic fashion moments from the Met Gala over the years, from Rihanna's massive yellow cape gown to Blake Lively's transforming Statue of Liberty dress.

Finally, we examine Anduril's Pulsar system - an AI-powered electronic warfare weapon that can rapidly jam devices like drones by disrupting their electromagnetic sensors and adapting to new threats on the fly.

From Perplexity's Discover feed:

Microsoft builds 500b parameter model
https://www.perplexity.ai/search/Microsoft-builds-500b-w_EGBxOzQJ22vgyqsJ2f8Q

OpenAI partners with StackOverflow
https://www.perplexity.ai/search/OpenAI-partners-with-UM5Pb5okTeuXXRjBg1tsvQ

New genetic cause of Alzheimer's
https://www.perplexity.ai/search/New-genetic-cause-ZXDR.AuuQhWxJBKljt0pAg

Iconic Met Gala looks
https://www.perplexity.ai/search/Iconic-Met-Gala-2LD0aQf7Tke8qjdU9o5qQQ

How Pulsar weapons jam electronics
https://www.perplexity.ai/search/How-Pulsar-weapons-_xZF5uuqRRC190YM2C4q0A

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