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Dr. Nolan Williams: Psychedelics & Neurostimulation for Brain Rewiring
Huberman Lab
TMS and Depression - What's the Relationship Between Depression and TMS?
Depression involves a disconnection between the brain's cingulate region, which detects conflicting information, and the left dorsolateral prefrontal cortex, responsible for regulating thoughts and feelings. In depressed states, the cingulate becomes overactive, while the dorsolateral fails to exert sufficient control, leading to a dysregulation of emotional responses. Transcranial Magnetic Stimulation (TMS) effectively reestablishes this regulatory relationship, improving depressive symptoms by enhancing the dorsolateral's governance over the cingulate. This 'exercise' for the brain helps patients better interpret physiological signals and manage spontaneous thoughts. Notably, patients undergoing a dense stimulation protocol often experience significant improvements within a short timeframe, sometimes leading to profound moments of mindfulness and presence that patients describe as novel and transformative. While these observations are anecdotal and lack extensive scientific backing, they highlight the potential of TMS not only to alleviate depression but also to enhance overall psychological well-being.
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