Will Shrank, MD, a venture partner at Andreessen Horowitz and former chief medical officer at CVS Health and Humana, discusses the shocking one trillion dollars wasted annually in U.S. healthcare. He highlights the need to align incentives with patient outcomes and the rising potential of primary care providers to combat this waste. The conversation delves into the evolution of value-based care, the challenges of the fee-for-service model, and innovative strategies to improve healthcare delivery and efficiency.