This engaging discussion features Justin Morgenstern, an expert in evidence-based medicine; Emily Wishart, Junior Doctor of the Year; Will Arnott, who tackles transfusion strategies; and Josh Priotti, a pediatric resident. They explore the nuances of comparing oral and intravenous antibiotics for pediatric infections, reveal insights from transfusion research in traumatic brain injury, and discuss how patients perceive their own outcomes. The conversation highlights the importance of patient engagement and the evolving landscape of medical understanding.