Sebastian Palmqvist, MD, PhD, and Wiesje van der Flier, PhD, are cochairs of the 2024 Alzheimer’s Association International Conference, while Rita Rubin serves as Lead Senior Staff Writer for JAMA Medical News. They delve into exciting topics like a groundbreaking blood test for Alzheimer’s, the repurposing of GLP-1 receptor agonists, and potential risks from inhaling wildfire smoke. They also discuss the importance of blood-based biomarkers and advancements in Alzheimer’s diagnosis and treatment, emphasizing the need for responsible implementation in clinical settings.