Dr. Wes Ely, MD, expert in ICU brain dysfunction, discusses important topics like prevention, diagnosis, and treatment of delirium in critical care. The conversation also touches on the impact of overuse of sedatives in COVID patients and the importance of family involvement. Implementing the ATF bundle for ICU patients and the use of medications and non-pharmacologic interventions in managing delirium are highlighted. The significance of patient's voice, compassion in critical care, and the speaker's focus on designing medical trials for long COVID immunomodulation are also covered.