Weihao Li, an advanced trainee in pediatric emergency medicine, dives into the intricate world of diagnosing appendicitis in children. The discussion covers a case of a young boy with abdominal pain and explores the complexities of symptoms and misdiagnoses. Weihao also reveals the rise of clinical prediction scores and their role in enhancing accurate diagnoses. Insights on clinician intuition, data collection challenges, and innovative methodologies illuminate the diagnostic landscape, all while keeping the tone light and engaging.