Veda Giri, an expert in early onset cancers from Yale, and Rebecca Siegel, a cancer statistics specialist at the American Cancer Society, explore the rising rates of cancers among young Americans and the socio-economic factors at play. Stephen Rosenberg discusses groundbreaking advancements in immunotherapy, highlighting their potential to revolutionize treatment. Otis Brawley and Valerie Lee focus on the unique needs of younger colorectal cancer patients, stressing the importance of tailored care and addressing disparities in health outcomes.