Dr Trish Greenhalgh explains how we miss the boat when we discount real-world evidence in favor of randomized trial evidence. This podcast is intended for US healthcare professionals only. To read a full transcript of this episode or to comment please visit: https://www.medscape.com/features/public/machine Eric J. Topol, MD, Director, Scripps Translational Science Institute; Professor of Molecular Medicine, The Scripps Research Institute, La Jolla, California; Editor-in-Chief, Medscape Abraham Verghese, MD, Physician, author, and educator; Professor and Vice Chair, Theory & Practice of Medicine, Department of Medicine, Stanford University, Stanford, California Trish Greenhalgh, OBE, MD, Professor of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom Orthodoxy, illusio, and playing the scientific game: a Bourdieusian analysis of infection control science in the COVID-19 pandemic [version 3; peer review: 2 approved]. Wellcome Open Res 2021, 6:126 https://doi.org/10.12688/wellcomeopenres.16855.3 Ten scientific reasons in support of airborne transmission of SARS-CoV-2. The Lancet, Vol 397; May 2021 https://doi.org/10.1016/S0140-6736(21)00869-2 Adapt or die: how the pandemic made the shift from EBM to EBM+ more urgent. BMJ Evidence-Based Medicine October 2022; volume 27; number 5 http://doi.org/10.1136/bmjebm-2022-111952 Long covid—an update for primary care. BMJ 2022;378:e072117 http://doi.org/10.1136/bmj-2022-072117 You may also like: Medscape's Chief Cardiology Correspondent Dr John M. Mandrola's This Week In Cardiology https://www.medscape.com/twic Discussions on topics at the core of cardiology and the practice of medicine with Dr Robert A. Harrington and guests on The Bob Harrington Show https://www.medscape.com/author/bob-harrington For questions or feedback, please email: news@medscape.net