Demetre Daskalakis, former CDC director, Debra Houry, the agency's ex-Chief Science Officer, and Dan Jernigan, a former infectious disease expert, discuss their resignations in protest against political pressures and management changes at the CDC. They dive into the philosophical debates surrounding health freedom, the impact of budget cuts on public health, and the complexities of restoring trust in health agencies post-COVID. The conversation also critiques the role of Big Pharma and highlights the urgent need for transparency in vaccine policies and decision-making.