Todd Golub, Director of the Broad Institute of MIT and Harvard, is a leading figure in cancer research and advocates for bottom-up creativity in science. He highlights how true scientific breakthroughs evolve from organic, collaborative efforts rather than strict designs. Golub discusses the importance of hiring researchers willing to embrace change and the synergy between art and science. He emphasizes that flexibility and interdisciplinary collaboration are vital for fostering innovative discoveries, urging scientists to embrace unexpected results.