In this thought-provoking discussion, guests Karl Friston, a leading theoretical neuroscientist, Mark Solms, a neuropsychoanalyst, Thomas Pollak, a neuropsychiatrist, and Chris Fields, a cognition researcher, dive into the nuances of introspection. They explore the balance between fast subconscious metacognition and slower, deliberate reflection. Topics include the importance of emotional foundations in consciousness, the risks of AI therapy, and how modifying preferences can lead to therapeutic change. The conversation also touches on regenerative biology and the implications of psychedelics for enhancing cognitive flexibility.