Tandi Bagian, a NASA veteran and expert in human factors, shares her insights from high-stakes environments. She discusses her journey as a woman in engineering and the vital role of curiosity in problem-solving. Tandi emphasizes the need for collaboration between humans and automation, especially in healthcare. She reflects on her experiences during the COVID vaccine rollout, advocating for proactive safety measures. The conversation also delves into the importance of open dialogue and adaptive decision-making in overcoming uncertainties in both life and science.