Dave Chokshi, a former NYC Health Commissioner known for his COVID-19 leadership, and Sunny Kishore, a physician-scientist at UCSF, join Dr. Murthy for heartfelt reflections on his tenure as Surgeon General. They discuss the challenges of loneliness and mental health, emphasizing their significance in public health. Personal stories highlight the power of meaningful connections in overcoming societal challenges. The conversation also touches on the critical role of deep listening in leadership and the lasting impact of love and relationships on well-being.