Dr. Steve Delisi, Chief Medical Officer at YourPath Inc., Co-Associate Director at UC-Irvine School of Medicine's 'Train New Trainers' Primary Care - Training and Education in Addiction Medicine Fellowship, Adjunct Professor at Hazelden Betty Ford Graduate School of Addiction Studies, discusses the fundamentals of substance use disorder, the neurobiology and clinical use of translational neuroscience, the relationship between trauma and substance use, best practices for building a therapeutic alliance, and future research on substance use disorders.