Stanley Lipkowitz
Researcher at the Women’s Malignancies Branch at the National Cancer Institute
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Apr 22, 2022 • 13min
Author Insight: How ONC201 Kills Breast Cancer Cells
Dr. Lipkowitz and Dr. Endo Greer from NCI discuss how ONC201 kills breast cancer cells by targeting mitochondria, not dependent on TRAIL receptors or caspases. ONC201 induces cell membrane ballooning and rupture, AMP-dependent kinase phosphorylation, and ATP loss, enhancing cytotoxicity in the absence of glucose. The drug indirectly inhibits mitochondrial respiration, showing potential in cancer therapy.
