Sidney LeFay, a psychiatry expert focused on psychedelics, discusses their therapeutic potential in treating anxiety and depression. The rise of interest in these substances highlights their historical and contemporary use. LeFay explains how psychedelics interact with the 5-HT2A receptor, offering insights into their mechanism of action. He emphasizes the importance of cautious research and the need to challenge the stigma surrounding these compounds. This conversation delves into how psychedelics may revolutionize psychopharmacology for mental health treatment.