CardioNerds podcast features Drs. Karishma Rahman, Shu Min Lao, and Constantine Troupes discussing a fascinating case of a 20-year-old woman with hypertension and possible mid-aortic syndrome. They explore the differential diagnosis of early-onset hypertension, imaging for diagnosis and surveillance, and treatment options. They also delve into large vessel vasculitis and the challenges in obtaining tissue diagnosis. Managing hypertension and IgG4-related disease, imaging results, and the importance of considering underlying causes of wall thickening are discussed.