Keith Humphreys, a Stanford psychiatry professor focused on addiction, joins Shrita Walden, the executive director of the Kentucky Harm Reduction Coalition. They discuss the unprecedented 15% drop in U.S. overdose deaths, citing improved access to treatment and education. The conversation highlights the importance of localized strategies to address disparities, especially in marginalized communities. They also delve into the shifting drug landscape and the need for sustained harm reduction efforts to address the ongoing opioid crisis.