Shefali Kakar

Global Head of PK Sciences and Oncology at Novartis, experienced in pharmacokinetics and applying data-driven approaches to drug development and clinical decision making.

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Dec 9, 2025 • 21min

Rethinking Clinical Trials with Faster AI-Driven Decision Making - with Shefali Kakar of Novartis

Shefali Kakar, Global Head of PK Sciences and Oncology at Novartis, shares her insights on how AI is revolutionizing drug development. She discusses the use of in silico modeling to predict safety and efficacy before producing molecules. Shefali emphasizes the importance of strategic capital allocation through advanced modeling to optimize R&D investments. Additionally, she highlights challenges like fragmented data and urges companies to learn from past failures to refine their approaches. Her advocacy for a 'fail fast' ethos aims to enhance patient safety while streamlining drug development.

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