Sheena O'Connell, a software developer, shares her transformative journey from a React-Django app to a streamlined Django+HTMX stack. She highlights how HTMX simplifies web development by reducing cognitive load and enabling developers to work in a single context. The conversation dives into her experience developing a learner management system during COVID-19, the challenges encountered, and the significant advantages HTMX brings in interactive applications. She also discusses innovative teaching strategies and effective coding practices for enhanced productivity.