Sen Zhang

Researcher in pharmacology and regenerative medicine presenting work on platelet factor 4 (PF4) and its role in hematopoietic stem cell aging, including mechanistic insights and translational implications for rejuvenation of aged HSCs.

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Dec 4, 2025 • 16min

Analysis of IELSG37 Trial Results and PF4 in Stem Cell Aging

In this discussion, Emanuele Zucca, an oncologist and lymphoma expert, delves into the IELSG37 trial, revealing that the standard R-CHOP21 regimen for primary mediastinal B-cell lymphoma may be less effective than hoped. Sen Zhang, a researcher in pharmacology, explores platelet factor 4's critical role in stem cell aging, highlighting how PF4 deficiency accelerates aging traits in stem cells. Both experts emphasize translational implications for improving therapies and rejuvenating aged hematopoietic stem cells, sparking new hope in regenerative medicine.

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